Quantitative model for assessment of lower‐extremity perfusion in patients with diabetes

Zhang, Qian; Liu, Xiaoxiao; Li, Qiang; Liu, Yushuang; He, Hongbo; Wang, Kaifa; Yan, Zhencheng

doi:10.1002/mp.16214

Cited by 3 publications

(7 citation statements)

References 20 publications

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“…Çelen et al reported that the mean perfusion reserve of the calf muscles in the DM group was signi cantly lower than in the control group [8]. Arteriolar dilatation, capillary permeability, and neuropathy are important factors in perfusion reserve [7,8,[14][15][16][17]. To determine the amputation level in our study, while evaluating the extremity perfusion of patients with DFU, the healthy contralateral LEs of the patients were examined under the same conditions and simultaneously and used as the control group.…”

Section: Discussionmentioning

confidence: 99%

“…99m Tc-MIBI uptake in cells depends on perfusion, viability, and mitochondrial activity [7,8,12,15]. Because of these properties, 99m Tc-MIBI is a radiopharmaceutical agent used in studies of tissue perfusion, viability, and evaluation of peripheral vascular diseases [7,8,[14][15][16][17]19]. In the literature, 99m Tc-MIBI has been used for perfusion imaging, particularly in LE peripheral vascular diseases [7,8,12,[15][16][17]19].…”

Section: Discussionmentioning

confidence: 99%

“…Although no study has evaluated the level of amputation using 99m Tc-MIBI, particularly in patients with DFU, studies evaluating the perfusion and viability of the musculoskeletal system in patients with DM are also quite limited [7,8,12,[15][16][17] In this study, we tried to determine the amputation level by evaluating the perfusion and vitality of the extremities of patients with DFU using the 99m Tc-MIBI technique, a nuclear imaging method. In this study, the 99m Tc-MIBI uptake rates of patients with poor prognosis were higher at all time points than in patients who did not require revision surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Because of these advantages and its high-quality image, many researchers prefer 99m Tc-MIBI in the investigation of peripheral ischemia and perfusion abnormalities in the lower extremities [7,8,[12][13][14][15][16][17]19].…”

Section: Discussionmentioning

confidence: 99%

“…There are studies evaluating musculoskeletal system perfusion and viability using 99mTc-MIBI in patients with DM [7,15] and both with and without DM [8, 14,16,17].. With this study, we aimed to determine the predictability of the amputation level to reduce the risk of amputation and develop better treatment strategies in patients with DFU. For this purpose, we evaluated the perfusion and viability of skeletal muscles using 99m Tc-MIBI in patients with DFU and tried to determine the relationship between the uptake rates recorded with 99m Tc-MIBI scintigraphy and amputation level and reamputation.…”

Section: Introductionmentioning

confidence: 99%

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Clinical value of Tc-99m MIBI scintigraphy for the level of lower limb amputation in patients with diabetic foot ulcers

ekici,

günay,

karaçavuş

et al. 2024

Preprint

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Background There is a positive relationship between mitochondrial damage in the cell and uptake in 99mTc-MIBI scintigraphy. Severe mitochondrial dysfunction with cell death occurs in patients with diabetic foot ulcers. 99mTc-MIBI scintigraphy should be considered in order to decide on the level of amputation. Methods Prospectively twenty-four patients with diabetic foot ulcers (DFUs) were included in the study. As a result of treatment that started with the hospitalization, patients whose DFUs healed and did not need surgical intervention were determined as group 1, and patients whose DFUs did not regress despite surgical and medical treatment and who required further surgical intervention were determined as Group 2. 99mTc-MIBI scintigraphy was obtained before surgery. The 99mTc-MIBI uptake rates of the injured foot relative to the healthy foot were recorded. Deep tissue culture was taken at surgery. ESR, WBC, CRP and albumin values of the patients were measured. Results In this study, 99mTc-MIBI uptake rates of patients with poor prognosis were higher at all times than in patients who did not require revision surgery. A significant difference was found between these values in the 10th- and 30th-second rates. While the CRP level was 86.04 ± 21.87 mg / dL in Group 1, it was measured as 144.43 ± 27.54 mg / dL in Group 2 (p = 0,040). There is a positive correlation between ulcerated foot / healthy foot 99mTc-MIBI involvement rates at 10 and 30 seconds and CRP values, and a negative correlation between albumin values. Conclusion There is a significant relationship between 99mTc-MIBI involvement rates and poor prognosis and reamputation. The correlation between CRP and albumin levels which are among the predictive values, and 99mTc-MIBI uptake confirms this relationship. In diabetic foot ulcers, which are difficult to management and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical value of Tc-99m MIBI scintigraphy for the level of lower limb amputation in patients with diabetic foot ulcers

ekici,

günay,

karaçavuş

et al. 2024

Preprint

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A review of fractional order epidemic models for life sciences problems: Past, present and future

Nisar,

Farman,

Abdel-Aty

et al. 2024

Alexandria Engineering Journal

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Untitled

2023

Progr. Fract. Differ. Appl.

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Both mathematics and science are important for one another and have a close relationship. It is impossible to dispute the significance of mathematics in a number of scientific disciplines, including electrical engineering, physics, biology, and medicine. Due to a number of applications of mathematical biology in the twenty-first century, researchers have taken a special interest in this field. Due to the complexity of the underlying connections, both deterministic and stochastic epidemiological models are founded on an inadequate understanding of the infectious network. Over the past several years, the use of different fractional operators to model the problem has grown, and it is now a common way to study how epidemics spread. New fractional operators, the infectious disease model has been studied in this paper. By using different numerical techniques and the time fractional parameters, the mechanical characteristics of the fractional order model are identified. The uniqueness and existence have been established. The model's local and global stability analysis has been found. In order to justify the theoretical results, numerical simulations are carried out for the presented method in the range of fractional order to show the implications of fractional and fractal orders. We applied very effective numerical technique to obtain the solutions of the model and simulations. Also, we present conditions of existence for a solution to the purposed epidemic model and to calculate the reproduction number in certain state conditions of the analyzed dynamic system. Infectious disease fractional order model is offered for analysis with simulations in order to determine the possible efficacy of disease transmission in the Community. The Fractal fractional operator is employed to study the dynamical transmission of diseases effect on society which is helpful for analysis, decision making, and disease control. Are treated with the Banach contraction principle. Microorganisms, interactions between individuals or groups, and environmental, social, economic, and demographic factors on a broader scale are all examples. Finally, numerical simulations that demonstrate the impact of fractional parameters on our found solutions are built to study the impact of the system parameter on the disease's spread. In conclusion, fractional operators in mathematical models can help decision-makers make better choices regarding the course of action to take in an epidemic situation. Further, we suggested some future work directions with the help of the new hybrid fractional operator. Fractional Calculus is a prominent topic for research within the discipline of Applied Mathematics due to its usefulness in solving problems in many different branches of science, engineering, and medicine. Recent researchers have identified the importance of mathematical tools in various disease models as being very useful to study the dynamics with the help of fractional and integer calculus modeling.

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Quantitative model for assessment of lower‐extremity perfusion in patients with diabetes

Cited by 3 publications

References 20 publications

Clinical value of Tc-99m MIBI scintigraphy for the level of lower limb amputation in patients with diabetic foot ulcers

Clinical value of Tc-99m MIBI scintigraphy for the level of lower limb amputation in patients with diabetic foot ulcers

A review of fractional order epidemic models for life sciences problems: Past, present and future

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