Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment

Berthet, B.; Sugarbaker, Tessa A.; Chang, David; Sugarbaker, Paul H.

doi:10.1016/s0959-8049(98)00375-x

Cited by 101 publications

(77 citation statements)

References 11 publications

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“…The change in PCI between the first and the second cytoreduction had a significant impact on prognosis in this report and in a prior report by Berthet et al 17 They reported that a small increase in the number of anatomic sites involved by sarcoma between a first operation and a definitive cytoreduction was associated with a good prognosis. In 11 patients, they reported an 80% 5-year survival rate.…”

Section: -15supporting

confidence: 69%

Second-Look Surgery in Patients With Peritoneal Dissemination From Appendiceal Malignancy: Analysis of Prognostic Factors in 98 Patients

Esquivel

Sugarbaker

2001

Annals of Surgery

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ObjectiveTo establish selection criteria for reoperation in patients with peritoneal dissemination from appendiceal malignancy. Summary Background DataThe outcome of patients with mucinous appendiceal neoplasms with peritoneal surface dissemination has changed as a result of a better understanding of the clinical and pathologic features of this disease. This knowledge, combined with aggressive strategies for the use of perioperative intraperitoneal chemotherapy and peritonectomy procedures, has resulted in long-term disease-free survival in many of these patients. However, some of the patients develop progressive disease, and a question regarding additional surgery is appropriate. A critical analysis of the results of second-look surgery should assist in the management of patients with recurrent peritoneal surface dissemination of an appendiceal neoplasm. MethodsThree hundred twenty-one patients with epithelial peritoneal surface malignancy of appendiceal origin underwent surgery during a 12-year period. Ninety-eight of these patients (30.5%) underwent a second-look procedure. A database of selected clinical features regarding these 98 patients was gathered from the clinical records. A critical statistical analysis of these clinical features and their prognostic impact was performed using survival as an endpoint. All patients were managed by a treatment regimen that used cytoreductive surgery and intraperitoneal chemotherapy. ResultsThe overall 5-year survival rate of these 98 patients was 73.6%. This compared favorably with a 68% survival rate of 223 patients who did not undergo reoperation. Survival based on the number of cytoreductive surgeries and the free interval between them showed no significant difference. Patients who had second-look surgery with bowel obstruction as a symptom and those in whom the amount of tumor was increased or minimally decreased at the first and second cytoreductions had a significantly inferior 5-year survival rate. A complete second cytoreduction was associated with an improved 5-year survival rate. ConclusionsFollow-up of patients treated for peritoneal dissemination from neoplasms of appendiceal origin is indicated. Selected patients in whom recurrence develops are candidates for repeat cytoreductive surgery plus intraperitoneal chemotherapy with curative intent.Peritoneal surface dissemination of pseudomyxoma peritonei and of adenocarcinomas of appendiceal origin has a perforated appendiceal tumor as the primary site of disease. 1Mucinous ascites and mucus-producing epithelial cells from the appendiceal tumor accumulate and progress, with a characteristic distribution throughout the abdomen and pelvis. Copious mucinous ascites and tumors distend the peritoneal cavity over time and eventually bring intestinal function to a halt. In the past, treatment involved repeated debulking procedures over several years. The goal of this surgery was to relieve the abdominal distention by evacuating all free mucus, irrigating vigorously, and wiping the peritoneal surfaces as clean as possi...

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Section: -15supporting

confidence: 69%

Second-Look Surgery in Patients With Peritoneal Dissemination From Appendiceal Malignancy: Analysis of Prognostic Factors in 98 Patients

Esquivel

Sugarbaker

2001

Annals of Surgery

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“…In a series of patients with colorectal cancer, Sugarbaker reported a 5-year survival rate of 50% when the PCI was less than 10, a rate of 20% for an index of 11-20, and a rate of 0% for an index > 20 [40] . Berthet et al [41] reported that the PCI score predicted a benefit to the visceral organs from the treatment of sarcomatosis. The PCI score system developed by Sugarbaker is now used worldwide for the assessment of PC from various tumor types.…”

Section: Quantitative Estimation and Preoperative Diagnosis Of Pcmentioning

confidence: 99%

Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer

Yonemura¹,

Elnemr²,

Endou³

et al. 2010

WJGO

120

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“…For low-grade tumors CC-0 and CC-1 cytoreductions are considered complete cytoreductive operations. The completeness of cytoreduction score is the most significant prognostic indicator of survival in patients with pseudomyxoma peritonei (Sugarbaker, 2006;Miner et al, 2005;Baratti et al, 2007) peritoneal mesothelioma (Yan et al 2007;Sebbag et al, 2000;Brigand et al, 2006;Deraco et al, 2006), colorectal cancer with peritoneal carcinomatosis Gomez-Portilla et al, 1999) gastric cancer with peritoneal carcinomatosis (Yonemura et al, 2003), and peritoneal sarcomatosis (Rossi et al, 2004;Berthet et al, 1999). The completeness of cytoreduction score in advanced ovarian cancer has been demonstrated to be a significant prognostic indicator of survival Tentes et al, 2006;Piso et al, 2004;Raspagliesi et al, 2006;Di Giorgio et al, 2008 (Tentes et al, 2006).…”

Section: Completeness Of Cytoreduction Scorementioning

confidence: 99%

Combined Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for the Treatment of Advanced Ovarian Cancer

Tentes¹,

Courcoutsakis²,

Prasopoulos³

2012

Ovarian Cancer - Clinical and Therapeutic Perspectives

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Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment

Cited by 101 publications

References 11 publications

Second-Look Surgery in Patients With Peritoneal Dissemination From Appendiceal Malignancy: Analysis of Prognostic Factors in 98 Patients

Second-Look Surgery in Patients With Peritoneal Dissemination From Appendiceal Malignancy: Analysis of Prognostic Factors in 98 Patients

Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer

Combined Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for the Treatment of Advanced Ovarian Cancer

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