Quantitative measurements of linear birefringence during heating of native collagen

Maitland, Duncan J.; Walsh, Joseph T.

doi:10.1002/(sici)1096-9101(1997)20:3<310::aid-lsm10>3.0.co;2-h

Cited by 115 publications

(89 citation statements)

References 15 publications

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“…The observable tissue retardance mainly originates from anisotropic fibrous tissue structures like collagen fibrils and elastin fibres, which are equivalent to uniaxial birefringent crystals [101][102][103]. Cancerous tissue is typically associated with changes in collagen components, e. g. deposition of collagen fibrils resulting from an increased number of fibroblasts [104].…”

Section: Polarized Light and Biological Tissuementioning

confidence: 95%

Mueller polarimetric imaging for surgical and diagnostic applications: a review

2017

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Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities. This review introduces the basis of the Stokes-Mueller formulism, interpretation methods of Mueller matrices into fundamental polarization properties, polarization properties of biological tissues, and considerations in the construction of Mueller polarimetric imaging devices for surgical and diagnostic applications, including primary configurations, optimization procedures, calibration methods as well as the instrument polarization properties of several widelyused biomedical optical devices. The paper also reviews recent progress in Mueller polarimetric endoscopes and fibre Mueller polarimeters, followed by the future outlook in applying the technique to surgery and diagnostics. Tissue polarization properties convey morphological, micro-structural and compositional information of tissue with great potential for label free characterization of tissue pathological changes. Recent progress in tissue polarimetric imaging and polarization resolved endoscopy paved the way for translation of polarimetric imaging to surgery and tissue diagnosis.

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Section: Polarized Light and Biological Tissuementioning

confidence: 95%

Mueller polarimetric imaging for surgical and diagnostic applications: a review

2017

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“…Initial studies [13] have indicated the potential for PS-OCT to solve this problem by taking advantage of the fact that skin contains collagen, a birefringent material [40,62]. At temperatures between 56 and 65°C, collagen begins to denature and lose its birefringence [41,147]. It should be expected that normal and burned skin differ in their natural collagen content, which leads to a reduction in the ability of burned skin to alter the polarization state of light that has passed through and been reflected back from some depth.…”

Section: Dermatology Collagen and Nerves Cartilage And The Reduced mentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

350

241

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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“…Thus, depolarization in turbid media has been applied as a gating technique to separate singly scattered, specularly reflected and multiply scattered light for the following scenarios: i) to enhance the image contrast near to the tissue surface [1]; ii) to extract single elastic scattering spectra from diffuse backgrounds for cell nucleus and cytoplasm size characterization [2,3]; iii) to improve image quality by removing specular reflections [4]: iv) to select well-defined subsurface volumes in a turbid medium [5]; v) to reveal features at depth such as pigmentation and vessels when detecting via cross polarizers [6]; vi) to correlate with tissue absorption and scattering [7]; and vii) for disease diagnosis [8][9][10]. In addition, a number of constituents in tissue including structural proteins like collagen, and chiral molecules like glucose, also manifest birefringence and optical rotation which can contribute to the detection of tissue abnormalities such as osteoarthritis, thermal injury and cancer [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Narrow band 3 × 3 Mueller polarimetric endoscopy

Singh

et al. 2013

Biomed. Opt. Express

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Mueller matrix polarimetric imaging has shown potential in tissue diagnosis but is challenging to implement endoscopically. In this work, a narrow band 3 × 3 Mueller matrix polarimetric endoscope was designed by rotating the endoscope to generate 0°, 45° and 90° linearly polarized illumination and positioning a rotating filter wheel in front of the camera containing three polarisers to permit polarization state analysis for backscattered light. The system was validated with a rotating linear polarizer and a diffuse reflection target. Initial measurements of 3 × 3 Mueller matrices on a rat are demonstrated, followed by matrix decomposition into the depolarization and retardance matrices for further analysis. Our work shows the feasibility of implementing polarimetric imaging in a rigid endoscope conveniently and economically in order to reveal diagnostic information. Martino, "Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging," J.

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Quantitative measurements of linear birefringence during heating of native collagen

Cited by 115 publications

References 15 publications

Mueller polarimetric imaging for surgical and diagnostic applications: a review

Mueller polarimetric imaging for surgical and diagnostic applications: a review

Polarization sensitive optical coherence tomography – a review [Invited]

Narrow band 3 × 3 Mueller polarimetric endoscopy

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