Quantitative Maximum Shear-Wave Stiffness of Breast Masses as a Predictor of Histopathologic Severity

Abstract

Despite overlap in Emax values, maximum stiffness measured by SWE is a highly effective predictor of the histopathologic severity of sonographically depicted breast masses.

Predictors of Invasive Breast Cancer in Patients With Ductal Carcinoma In Situ in Ultrasound‐Guided Core Needle Biopsy

“…Results have consistently shown that high‐grade tumors tend to have greater stiffness on elastography. The maximum stiffness of IDC has been shown to be greater than that of DCIS in previous studies; tumors tend to become stiffer as they grow because of the increase of fibrosis and decrease of necrosis.…”

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

“…Tumor stiffness, assessed with ultrasound elastography or atomic force microscopy appears to increase with increasing grade [91] and predicts poorer prognosis [92]. SPARC/ OSTEONECTIN Microarray for 7 genes which correlate with SPARC 1729 systemically untreated patients from previously published datasets SPARC tends to be highest in luminal-A type, followed by luminal-B followed by basal [63] High SPARC predicts worse survival in HER2 þ, and basal cancers Furthermore, successful chemotherapy decreases tumor stiffness whereas stiffening is observed in chemotherapy-resistant tumors stiffen after treatment [93].…”

Shear Wave Elastography (SWE) for the Evaluation of Patients with Tendinopathies

“…SWE has been used to evaluate liver stiffness and stiffness of breast (13,14), prostate (15,16), and thyroid lesions (17). SWE seems to increase specificity and positive predictive value in the assessment of breast (18,19) and prostate lesions (15).…”