Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe

Zhang, Peisen; Zeng, Jianfeng; Li, Yingying; Yang, Chen; Meng, Junwei; Hou, Yi; Gao, Mingyuan

doi:10.1002/anie.202014348

Cited by 62 publications

(50 citation statements)

References 46 publications

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“…However, it exhibited dramatically enhanced T 2 enhancement in GSH-rich environment as GSH can reduce the disulfide bonds embedded in the peptide sequence to generate thiol groups that react with the maleimide groups from the adjacent USPIO particles to glue them together. It was further demonstrated that such GSH-induced particle aggregation could give rise to interlocked T 1 and T 2 signal variations, which were proven to quantitatively correlate with GSH concentration to enable the GSH mapping of intracranial tumor in vivo (Zhang et al, 2021).…”

Section: Outstanding Mri Performancementioning

confidence: 97%

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Chen

Gao

et al. 2021

WIREs Nanomed Nanobiotechnol

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As a research hotspot, the development of magnetic resonance imaging (MRI) contrast agents has attracted great attention over the past decades for improving the accuracy of diagnosis. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with core diameter smaller than 5.0 nm are expected to become a next generation of contrast agents owing to their excellent MRI performance, long blood circulation time upon proper surface modification, renal clearance capacity, and remarkable biosafety profile. On top of these merits, USPIO nanoparticles are used for developing not only T 1 contrast agents, but also T 2 /T 1 switchable contrast agents via assembly/disassembly approaches. In recent years, as a new type of contrast agents, USPIO nanoparticles have shown considerable applications in the diagnosis of various diseases such as vascular pathological changes and inflammations apart from malignant tumors. In this review, we are focusing on the state-of-the-art developments and the latest applications of USPIO nanoparticles as MRI contrast agents to discuss their advantages and future prospects. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imagingcontrast agents, iron oxide nanoparticles, magnetic resonance imaging, ultrasmallCan Chen and Jianxian Ge contributed equally to this study.

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Section: Outstanding Mri Performancementioning

confidence: 97%

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Chen

Gao

et al. 2021

WIREs Nanomed Nanobiotechnol

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“…Precise diagnosis is the prerequisite for successful therapy, and to avoid false‐positive signals it is important to provide smart fluorescent probes which only respond to some specific disease‐related stimuli. [ 188,189 ] Such NIR‐II probes based on Ag 2 S SNCs were designed by Wang and co‐workers for accurate diagnosis of traumatic brain injury, acute myeloid leukemia, and cancer. [ 94,190,191 ] Outside the target region, the fluorescence of the nanoprobe was in the “off” state owing to the fluorescence resonance energy transfer (FRET) from Ag 2 S SNCs to the attached A1094 chromophore.…”

Section: Applications Of Nir‐ii Emitting Sncs In Biomedical Imaging T...mentioning

confidence: 99%

Semiconductor Nanocrystals Emitting in the Second Near‐Infrared Window: Optical Properties and Application in Biomedical Imaging

Jiao

Portniagin

Liu

et al. 2022

Advanced Optical Materials

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Development of fluorophores with emission in the so‐called second near‐infrared window (NIR‐II, 1000–1700 nm) represents an active area of the contemporary research. Among the available NIR‐II fluorophores, semiconductor nanocrystals are attractive owing to their high brightness, broad excitation profile, easily adjustable emission wavelength, and superior stability. At the same time, for the biomedical applications, biocompatibility of semiconductor nanocrystals is yet another important requirement. The recent advances in the synthesis of NIR‐II emitting semiconductor nanocrystals based on I‐VI, III‐V, and I‐III‐VI compound semiconductors are reviewed, placing special emphasis on the efforts to enhance their NIR‐II emission intensity and photostability. Representative examples of their applications for biomedical imaging, therapy and surgery are provided. This review is concluded by offering perspectives on how to further improve the performance of these attractive class of NIR‐II fluorophores.

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“…Medical imaging is one of the most important means of non-invasive studies ( Yang et al, 2017 ; Zhang et al, 2019 ; Zhang et al, 2020 ; Zhao et al, 2021 ). Especially, magnetic resonance imaging (MRI), one of the clinically compatible imaging modalities, have led to improved accuracy in the detection and characterization of central nervous system diseases, which can provide images of anatomical structure of the brain with high spatial resolution for studying pathologic foci ( Iima and Le Bihan, 2016 ; Fan, 2021 ; Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

et al. 2021

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Polymyxin B (PMB) exert bactericidal effects on the cell wall of Gram-negative bacteria, leading to changes in the permeability of the cytoplasmic membrane and resulting in cell death, which is sensitive to the multi-resistant Gram-negative bacteria. However, the severe toxicity and adverse side effects largely hamper the clinical application of PMB. Although the molecular pathology of PMB neurotoxicity has been adequately studied at the cellular and molecular level. However, the impact of PMB on the physiological states of central nervous system in vivo may be quite different from that in vitro, which need to be further studied. Therefore, in the current study, the biocompatible ultra-uniform Fe3O4 nanoparticles were employed for noninvasively in vivo visualizing the potential impairment of PMB to the central nervous system. Systematic studies clearly reveal that the prepared Fe3O4 nanoparticles can serve as an appropriate magnetic resonance contrast agent with high transverse relaxivity and outstanding biosafety, which thus enables the following in vivo susceptibility-weighted imaging (SWI) studies on the PMB-treated mice models. As a result, it is first found that the blood-brain barrier (BBB) of mice may be impaired by successive PMB administration, displaying by the discrete punctate SWI signals distributed asymmetrically across brain regions in brain parenchyma. This result may pave a noninvasive approach for in-depth studies of PMB medication strategy, monitoring the BBB changes during PMB treatment, and even assessing the risk after PMB successive medication in multidrug-resistant Gram-negative bacterial infected patients from the perspective of medical imaging.

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Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe

Cited by 62 publications

References 46 publications

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Semiconductor Nanocrystals Emitting in the Second Near‐Infrared Window: Optical Properties and Application in Biomedical Imaging

Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

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