Quantitative Inhalationsszintigraphie bei Lungengesunden und Patienten mit chronisch obstruktiver Atemwegserkrankung

Abstract

A quantitative method for study of the penetration, deposition pattern and clearance of inhaled particles (O,5-micron-99Tc-labeled human serum millimicrospheres) in the lung is described. 10 healthy subjects and 15 patients with chronic obstructive lung disease (COLD) were studied. For both groups significant differences in the mean values of two indices describing peripheral particle penetration and particle distribution homogeneity were observed. Mucociliary efficiency has been assessed by evaluating aerosol clearance rates from the whole right lung and from upper, middle, lower, perihilar and peripheral zones of the right lung field. Whereas the total lung clearance of both groups showed no marked difference, there was a statistical significant clearance delay in the patient's group upper and peripheral lung area.

Influence of Propranolol, Metoprolol, and Pindolol on Mucociliary Clearance in Patients with Coronary Heart Disease

“…In these patients, who are very often smokers, firstly a dysfunction of the self-clearance mechanisms of the lung is observed, followed by the develop ment of ordinary smoker's bronchitis [6]. Consecutive mucostase, detritus nidation and the insufficient removal of inhaled toxic agents all increase the irritability of the bronchial mucosa.…”

“…Its in teraction with mucus consistence deter mines the mucociliary clearance [1]. De fects in mucociliary transport are common in patients with chronic obstructive lung disease [2,3], This type of lung dysfunc tion is often found in patients with coro nary heart disease (CHD), especially when they are smokers [4][5][6]. In these patients, therapy of CHD with /I-adrenoceptorblocking drugs may lead to further deteri oration of mucociliary transport, with in creased deterioration of pulmonary and cardiac function [7].…”