Quantitative impact analysis of remote ischemic conditioning and capsaicin application on human skin microcirculation

Rothenberger, Jens; Wittwer, Matthias; Tschumi, Christian; Constantinescu, Mihai A.; Daigeler, Adrien; Olariu, Radu

doi:10.3233/ch-180373

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…The most commonly used substance is capsaicin. Capsaicin is a powerful vasodilator and is known to significantly increase skin perfusion (49,50). Pain-related small fiber functions, symptomology and microcirculatory response are studied through histamine-or capsaicin-evoked axon flare responses are currently visualized by LASCA or photoplethysmography (22,41,49).…”

Section: Pain Sensation Mediated By Small Fiber Nervesmentioning

confidence: 99%

A Synoptic Overview of Neurovascular Interactions in the Foot

et al. 2020

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Diabetes is a worldwide public health concern as it is associated with various complications. One of the major complications of diabetes is diabetic foot syndrome that results in catastrophic events such as ulceration and amputation. Therefore, the main four strategies of diabetic foot care involve risk prediction, prevention, and early diagnosis and prompt intervention. The drivers of ulceration are multifactorial, and importantly, include microcirculatory changes in the diabetic skin. Cutaneous microcirculation on the foot is greatly influenced by the small fibers which mediate thermal sensation and pain perception in addition to sympathetic activities such as thermoregulation and vasodilation. The interdependence between the neurovascular elements means with the loss of small fiber functions, the corresponding microcirculatory responses may be compromised. Thus, it can be hypothesized that the impairment of the microcirculation may follow the order of the corresponding small fiber nerve dysfunction or vice versa. In this review, select neurovascular investigations that inform the cutaneous microcirculatory and small fiber nerve function in response to pain, cold, and heat and pressure stimuli are reviewed and discussed in this order of sensory loss: the loss of pain, cold, warmth, touch and deep pressure sensation. We also discuss the neurological and vascular characteristics of each of these neurovascular responses. This review highlights the influence of small fibers on cutaneous microcirculation and the need for prospective studies that can determine the course of microcirculatory impairment over time. This, in turn, may help clarify the exact role of microcirculatory changes in the pathway of ulceration. The insights from this review can be pertinent to understand key microcirculatory disturbances and given that the microcirculatory impairment develops at an early stage, relevant interventions can be implemented to possibly reverse or regress the course of the disease. Therefore, knowledge of the neurovascular interactions aids to map the disease progression for early diagnosis and prevention of adverse complications.

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Section: Pain Sensation Mediated By Small Fiber Nervesmentioning

confidence: 99%

A Synoptic Overview of Neurovascular Interactions in the Foot

et al. 2020

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“…Application of polylactic copolymer reduced pain and enabled administration of the full radiation protocol preventing skin from deep radiative injury. After 10 days from application on the injured side, full re-epithelialization was observed [77].…”

Section: Paradigm Shift Inmentioning

confidence: 99%

Alloplastic Epidermal Skin Substitute in the Treatment of Burns

Barbachowska,

Korzeniowski,

Surowiecka

et al. 2023

Life

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The goal of burn wound treatment is to ensure rapid epithelialization in superficial burns and the process of rebuilding the lost skin in deep burns. Topical treatment plays an important role. One of the innovations in the field of synthetic materials dedicated to the treatment of burns is epidermal skin substitutes. Since the introduction of Suprathel®, the alloplastic epidermal substitute, many research results have been published in which the authors investigated the properties and use of this substitute in the treatment of wounds of various origins, including burn wounds. Burn wounds cause both physical and psychological discomfort, which is why ensuring comfort during treatment is extremely important. Alloplastic epidermal substitute, due to its biodegradability, plasticity, no need to remove the dressing until healing, and the associated reduction in pain, is an alternative for treating burns, especially in children.

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“…Based on its properties, capsaicin is already used in a number of applications, as a component of animal repellents [28][29][30], fragrances [31,32], pesticides [33,34], and also in veterinary medicine [35,36]. A number of medical uses were reported, most notably as a treatment for chronic pain [37][38][39][40] and pruritus [41][42][43][44]; other minor uses have also been described by various researchers [45][46][47][48][49][50][51][52]. It should be noted that capsaicin is also capable of inducing local inflammation [53], a process which can be objectively measured through modern imaging applications [54,55].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Periferakis,

Periferakis

et al. 2023

Nutrients

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Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject of intensive phytochemical research due to its numerous physiological and therapeutical effects, including its important antimicrobial properties. Depending on the concentration and the strain of the bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against a wide range of both Gram-positive and Gram-negative bacteria, while in certain cases it can reduce their pathogenicity by a variety of mechanisms such as mitigating the release of toxins or inhibiting biofilm formation. Likewise, capsaicin has been shown to be effective against fungal pathogens, particularly Candida spp., where it once again interferes with biofilm formation. The parasites Toxoplasma gondi and Trypanosoma cruzi have been found to be susceptible to the action of this compound too while there are also viruses whose invasiveness is significantly dampened by it. Among the most encouraging findings are the prospects for future development, especially using new formulations and drug delivery mechanisms. Finally, the influence of capsaicin in somatostatin and substance P secretion and action, offers an interesting array of possibilities given that these physiologically secreted compounds modulate inflammation and immune response to a significant extent.

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Quantitative impact analysis of remote ischemic conditioning and capsaicin application on human skin microcirculation

Cited by 5 publications

References 20 publications

A Synoptic Overview of Neurovascular Interactions in the Foot

A Synoptic Overview of Neurovascular Interactions in the Foot

Alloplastic Epidermal Skin Substitute in the Treatment of Burns

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

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