Quantitative immunocytochemical study of plasma cells in skin tumoral stromal reaction

Bustamante, R.; Faure, Michel; Bejui, F; Thivolet, J

doi:10.1016/0014-2964(78)90059-2

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…The immunocytochcmical identification of immunoglobulin producing cells in skin stromal reactions of various cutaneous hyperplastie and tumorous processes including skin carcinomas and melanomas has been carried out , using PO and anti-Ig antisera (Bustamante et al 1978).…”

Section: Skin Cellular Infiltratesmentioning

confidence: 99%

Immunohistochemistry in cutaneous pathology

Thivolet

Faure

1983

J Cutan Pathol

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Since the first demonstration of skin antibodies in sera of pemphigus patients by IF (Beutner & Jordon 1964), the scope of skin diseases in which immunologic findings may be of interest has enormously enlarged and dermatology remains one of the leading clinical specialities applying IHC in both diagnosis and research. Immunohistological techniques and, to a lesser degree, immunocytological techniques, have been developed to include not only IF, but also immunoenzymatic methods. Even if not all immunological findings may be disease specific and diagnostic, immunohistological techniques have become a very useful tool for studying skin biopsies in connection with serological methods. Their importance could be increased with rapid development to a new field: the study of normal skin constituents; e.g. Ag, collagen, keratin, with the help of specific polyclonal and monoclonal antibodies.

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Section: Skin Cellular Infiltratesmentioning

confidence: 99%

Immunohistochemistry in cutaneous pathology

Thivolet

Faure

1983

J Cutan Pathol

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“…The labelling is very stable and counterstaining such as Mayer's haemalum, melhyl blue or methyl pyronine green (Bustamante et al 1978), may be used to make the reading easier. PO may be applied on frozen as well as fixed sections.…”

Section: Tj) Peroxidase Labetling and Other Immtinoenzymaiic Lechniqtmentioning

confidence: 99%

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1983

J Cutan Pathol

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Plasma cells and immunoglobulin-synthesis in oral precancer and cancer

Löning

Burkhardt

1979

Virchows Arch. A Path. Anat. and Histol.

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The subepithelial and peritumoral inflammatory infiltrates of 202 oral premalignant and malignant lesions -- 108 leukoplakias and 94 squamous cell carcinomata with different grades of dysplasia were examined using an immunoenzymatic method. In addition, the influence of radiation and bleomycin-therapy on the stromal reaction of 24 carcinomata was studied. The incidence of immunoglobulin labelled plasma cells (IgA and IgG) was twice as high in those cases of leukoplakia where dysplasia was present. The number of plasma cells, especially IgA- and IgG-containing plasma cells, decreased significantly with progressive tumor dedifferentiation. The plasma cell response differed before and after radiation with a decrease in IgA- and IgG-containing plasma cells after therapy. In contrast, bleomycin-therapy did not produce distinct changes in the humoral and cellular stromal reaction. In the epithelium, IgA and IgG were localized throughout all epithelial layers in leukoplakias with dysplasia. This finding indicates a leakage of locally synthesized immunoglobulins through an altered oral mucosa. This investigation reveals alterations in the local immune homoeostasis of the oral mucosa in premalignant and malignant lesions which varies with the grade of dysplasia, tumor differentiation and therapy.

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Quantitative immunocytochemical study of plasma cells in skin tumoral stromal reaction

Cited by 7 publications

References 17 publications

Immunohistochemistry in cutaneous pathology

Immunohistochemistry in cutaneous pathology

Untitled

Plasma cells and immunoglobulin-synthesis in oral precancer and cancer

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