Quantitative imaging metrics derived from magnetic resonance fingerprinting using ISMRM/NIST MRI system phantom: An international multicenter repeatability and reproducibility study

Abstract

Purpose: To compare the bias and inherent reliability of the quantitative (T 1 and T 2 ) imaging metrics generated from the magnetic resonance fingerprinting (MRF) technique using the ISMRM/NIST system phantom in an international multicenter setting. Method: ISMRM/NIST MRI system phantom provides standard reference T 1 and T 2 relaxation values (vendor-provided) for each of the 14 vials in T 1 and T 2 arrays. MRF-SSFP scans repeated over 30 days on GE 1.5 and 3.0 T scanners at three collaborative centers. MRF estimated T 1, and T 2 values averaged over 30 days were compared with the phantom vendor-provided and spin-echo (SE) based convention gold standard (GS) method. Repeatability and reproducibility were characterized by the within-case coefficient of variation (wCV) of the MRF data acquired over 30 days, along with the biases. Result: For the wide ranges of MRF estimated T 1 values, vials #1-8 (T 1 relaxation time between 2033 and 184 ms) exhibited a wCV less than 3% and 4%, respectively, on 3.0 and 1.5 T scanners. T 2 values in vials #1-8 (T 2 relaxation, 1044-45 ms) have shown wCV to be <7% on both 3.

Tailored magnetic resonance fingerprinting for simultaneous non‐synthetic and quantitative imaging: A repeatability study

“…TMRF is susceptible to errors in the range of small T 1 and T 2 values (spheres greater than 9). This is in line with previous repeatability studies that have evaluated ISMRM/NIST phantom up to sphere 8 a or 9 b only 25,29 …”

“…28 Konar et al investigated MRF repeatability as part of a multisite, two-field strength study. 29 This study demonstrates TMRF's repeatability of DLbased tissue parameter mapping and multi-contrast imaging. To this end, we (1) perform gold standard (GS) T 1 and T 2 measurements on the ISMRM/NIST phantom on a wide bore (70 cm) scanner; (2) introduce TMRF-based non-synthetic imaging and compare with GS vendor sequence and MRF; (3) demonstrate TMRF repeatability on an in vitro ISMRM/NIST phantom over 30 days and in vivo healthy human brains for 10 volunteers over five repetitions and two runs.…”

Toward magnetic resonance fingerprinting for low‐field MR‐guided radiation therapy

“…Similar to the work of Assländer et al., 40 this rapid scan time was achieved by acquiring a single radial k ‐space spoke per point in the MRF pattern for each phase‐encoded 3D partition. A minor underestimation of T 1 and T 2 values was observed, though this is consistent with other MRF validation studies 10,22,41 . In Figure 3, the Bland–Altman plots appear to show a dependence of the difference in MRF‐ and GS‐derived T 1 and T 2 estimates on mean T 1 and T 2 times.…”

“…Recent work has also highlighted the high degree of repeatability and reproducibility of MRF-based measurements of T 1 and T 2 at field strengths of 1.5T and 3T between three international centers. 41 In vivo, the observed T 1 and T 2 values from the MRF dataset in frontal white matter of 433.1 and 55.5 ms, respectively, were comparable to the T 1 (390-414 ms) and T 2 (54.3 ms) times available in the literature at 0.35T. 3,45 The elongated T 1 and T 2 times in the peripheral zone of the prostate relative to those within the central gland as observed by MRF here at 0.35T are not directly comparable to those observed at high field, but they exhibit a similar magnitude of difference between these areas of the prostate as those measured at 3T 12 (i.e., approximately two to three times longer T 1 values and three to four times longer T 2 values).…”

Cartesian dictionary‐based native T1 and T2 mapping of the myocardium

“…The International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) phantom was scanned to evaluate any heart-rate dependency. 33,34 Multimapping scans were performed with different heart-rates, from 40 bpm to 120 bpm with 20 bpm increments, to determine any heart-rate dependency. Reference T 1 and T 2 values were obtained using inversion recovery spin echo (IRSE) for T 1 , and multiecho spin echo (MESE) for T 2 .…”