Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines

Elmasry, Manal S.; Blagbrough, Ian S.; Rowan, Michael G.; Saleh, Hanaa; Kheir, Afaf Aboul; Rogers, Philip J.

doi:10.1016/j.jpba.2010.10.002

Cited by 52 publications

(15 citation statements)

References 22 publications

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“…Peel et al, 1994 [22] and Coward et al, 1995 [23] had reported interference of SSZ with the HPLC assay of urine and 5-hydroxyindole-3-acetic acid, respectively. The most recent report on any analytical method for SSZ was published in 2011 where an HPLC method was developed for the quantification of SSZ along with mebeverine, mesalazine, and dispersible aspirin [24]. A thin-layer chromatography method was also reported for the characterization of process-related impurities in SSZ [25].…”

Section: Introductionmentioning

confidence: 99%

Degradation Study on Sulfasalazine and a Validated HPLC-UV Method for its Stability Testing

Saini

2014

Sci. Pharm.

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Sulfasalazine (SSZ) was subjected to degradation under the conditions of hydrolysis (acid, alkali, and water), oxidation (30% H2O2), dry heat, and photolysis (UV-VIS light) in accordance with the ICH guidelines. An RP-HPLC method was developed to study the degradation behavior. No degradation was noted under any condition except alkaline hydrolysis where SSZ was degraded to a single minor product. SSZ was optimally resolved from this product on an XTerra® RP18 column with a mobile phase composed of methanol and an ammonium acetate buffer (10 mM, pH 7.0) (48:52, v/v) delivered at a rate of 0.8 mL/min in an isocratic mode. The method was validated and found to be linear (r2=0.99945), precise (%RSD <2), robust, and accurate (94–102%) in the concentration range of 0.5–50 μg/mL of SSZ. The PDA analysis of the degraded sample revealed the SSZ peak purity to be 998.99 and the drug peak eluted with a resolution factor of >2 from the nearest resolving peak, indicating the method to be selectively stability-indicating for the drug analysis. The method was applied successfully for the stability testing of the commercially available SSZ tablets that were under varied ICH-prescribed conditions. An explanation for the unusual stability of the drug when exposed to acidic hydrolysis, despite the presence of the sulfonamide linkage, is also discussed.

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Section: Introductionmentioning

confidence: 99%

Degradation Study on Sulfasalazine and a Validated HPLC-UV Method for its Stability Testing

Saini

2014

Sci. Pharm.

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“…These include liquid chromatography (Boixa et al, 2015;Malisetty & Rambabu, 2013), high performance liquid chromatography (HPLC) (El-Din, Eid, & Zeid, 2013;Elmasry et al, 2011), spectrofluorimetry (Alves & Poppi, 2009;Zadeh, Kohansal, & Sadeghi, 2011), potentiometry (Pasekova, Sales, Montenegro, Araujo, & Polasek, 2001), voltammetry (Sanghavi & Srivastava, 2010;Torriero, Luco, Sereno, & Raba, 2004), capillary electrophoresis (Marra et al, 2014), UV-Vis spectrophotometry (Abdelrahman, 2014;Sena & Poppi, 2004;Yamamoto, Takakuwa, Kato, & Asakaw, 2007) and flow injection analysis (FIA) with spectrophotometric detection (Lopez-Fernandez, Castro, & Valcarcel, 1990;Pereira, Aniceto, & Fatibello-Filho, 1998) and chemiluminescence (Wabaidur, Alam, Alothman, & Eldesoky, 2014).…”

Section: Figure (1): Chemical Structure Of Acetylsalicylic Acidmentioning

confidence: 99%

Flow Injection Chemiluminescence Determination of Acetylsalicylic Acid in Pharmaceutical Formulations

Jabbar

2016

SJUOZ

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ABSTRACT:A simple and sensitive flow injection chemiluminescence method was proposed for the determination of acetylsalicylic acid (aspirin) in pharmaceutical formulations. The method was based on inhibition effect of acetylsalicylic acid on the chemiluminescence reaction of luminol-hydrogen peroxide and potassium hexacyanoferrate. Different experiment parameters affecting the chemiluminescence intensity were carefully studied and incorporated into the procedure. The detection limit was 0.5 μg/mL of acetylsalicylic acid, and chemiluminescence emission intensity was correlated with the drug concentration in the range 2.5-125 μg/mL with correlation coefficient of 0.9985 and analytical frequency of 75 determinations per hour. The results obtained for the assay of pharmaceutical formulations were compared well with those obtained by the official method in British Pharmacopoeia and demonstrated good accuracy and precision.

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“…In 1763 the active ingredient of Aspirin was discovered by Edward Stone from the bark of the willow. A number of analytical approaches have been employed to analyse ASA such as: highperformance liquid chromatography-mass spectrometry [2][3][4][5][6] and gas chromatography-mass spectrometry [7], ultra performance liquid chromatography tandem mass spectrometry [8] and capillary electrophoresis [9] have also been reported for the determinations of ASA. However, many of these methods require sample pre-treatment, several timeconsuming manipulation steps, sophisticated instruments and special training.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical electrochemistry: The electrochemical detection of aspirin utilising screen printed graphene electrodes as sensors platforms

Kruanetr

Prabhu

Pollard

et al. 2015

Surf. Engin. Appl.Electrochem.

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Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines

Cited by 52 publications

References 22 publications

Degradation Study on Sulfasalazine and a Validated HPLC-UV Method for its Stability Testing

Degradation Study on Sulfasalazine and a Validated HPLC-UV Method for its Stability Testing

Flow Injection Chemiluminescence Determination of Acetylsalicylic Acid in Pharmaceutical Formulations

Pharmaceutical electrochemistry: The electrochemical detection of aspirin utilising screen printed graphene electrodes as sensors platforms

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