Quantitative Histological Validation of Diffusion MRI Fiber Orientation Distributions in the Rat Brain

Leergaard, Trygve B.; White, Nathan S.; Crespigny, Alex de; Bolstad, Ingeborg; D’Arceuil, Helen; Bjaalie, Jan G.; Dale, Anders M.

doi:10.1371/journal.pone.0008595

Cited by 164 publications

(181 citation statements)

References 52 publications

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“…Finally, our 3 HeMR measurements were highly repeatable, with a within-subject coefficient of variation of ADC of 3.1%, similar to the value reported by Altes and coworkers (34). We therefore conclude that our technique could have reliably detected structurally and clinically significant differences in alveolar dimensions among the groups if they existed (35).…”

Section: Discussionsupporting

confidence: 87%

Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance

Narayanan

Beardsmore

Owers‐Bradley

et al. 2013

Am J Respir Crit Care Med

130

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Rationale: Histologic data from fatal cases suggest that extreme prematurity results in persisting alveolar damage. However, there is new evidence that human alveolarization might continue throughout childhood and could contribute to alveolar repair. Objectives: To examine whether alveolar damage in extreme-preterm survivors persists into late childhood, we compared alveolar dimensions between schoolchildren born term and preterm, using hyperpolarized helium-3 magnetic resonance. Methods: We recruited schoolchildren aged 10-14 years stratified by gestational age at birth (weeks) to four groups: (1) term-born (37-42 wk; n ¼ 61); (2) mild preterm (32-36 wk; n ¼ 21); (3) extreme preterm (,32 wk, not oxygen dependent at 4 wk; n ¼ 19); and (4) extreme preterm with chronic lung disease (,32 wk and oxygen dependent beyond 4 wk; n ¼ 18). We measured lung function using spirometry and plethysmography. Apparent diffusion coefficient, a surrogate for average alveolar dimensions, was measured by helium-3 magnetic resonance. Measurements and Main Results: The two extreme preterm groups had a lower FEV 1 (P ¼ 0.017) compared with term-born and mild preterm children. Apparent diffusion coefficient was 0.092 cm 2 /second (95% confidence interval, 0.089-0.095) in the term group. Corresponding values were 0.096 (0.091-0.101), 0.090 (0085-0.095), and 0.089 (0.083-0.094) in the mild preterm and two extreme preterm groups, respectively, implying comparable alveolar dimensions across all groups. Results did not change after controlling for anthropometric variables and potential confounders. Conclusions: Alveolar size at school age was similar in survivors of extreme prematurity and term-born children. Because extreme preterm birth is associated with deranged alveolar structure in infancy, the most likely explanation for our finding is catch-up alveolarization.Keywords: alveolar structure; lung acinus; bronchopulmonary dysplasia; neonatal chronic lung disease Advances in preterm care have led to increased survival of extremely premature babies, with increasing numbers reaching adulthood. This has shifted the focus of research from survival toward long-term sequelae of prematurity (1, 2). Infants born extremely preterm are known to have arrested alveolar development, manifesting as fewer and larger alveoli (3, 4). Schoolage and adult survivors of extreme preterm birth are known to have long-term respiratory problems, particularly decreased forced expiratory volumes and increased residual lung volumes, suggesting airway damage (5, 6). There are insufficient data regarding structure and development of the periphery of the lung in long-term survivors of preterm birth because studies on this cohort have relied on traditional lung function tests that only provide an overall estimate of function.The short-and long-term outcomes described previously correlate with gestational age (GA) at birth and the presence of chronic lung disease of prematurity (CLD), one of the early pulmonary sequelae of extreme preterm birth (6-8). Most evidence regard...

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Section: Discussionsupporting

confidence: 87%

Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance

Narayanan

Beardsmore

Owers‐Bradley

et al. 2013

Am J Respir Crit Care Med

130

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“…A possible mechanism for AD increase is greater coherence and alignment of the axons 21, 25, 28, 29. Alongside this, increases in MD suggest disruption of WM microstructure perhaps as a result of decreased axonal or myelin content.…”

Section: Discussionmentioning

confidence: 98%

Long‐term white matter tract reorganization following prolonged febrile seizures

et al. 2017

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SummaryObjectiveDiffusion magnetic resonance imaging (MRI) studies have demonstrated acute white matter changes following prolonged febrile seizures (PFS), but their longer‐term evolution is unknown. We investigated a population‐based cohort to determine white matter diffusion properties 8 years after PFS.MethodsWe used diffusion tensor imaging (DTI) and applied Tract‐Based Spatial Statistics for voxel‐wise comparison of white matter microstructure between 26 children with PFS and 27 age‐matched healthy controls. Age, gender, handedness, and hippocampal volumes were entered as covariates for voxel‐wise analysis.ResultsMean duration between the episode of PFS and follow‐up was 8.2 years (range 6.7–9.6). All children were neurologically normal, and had normal conventional neuroimaging. On voxel‐wise analysis, compared to controls, the PFS group had (1) increased fractional anisotropy in early maturing central white matter tracts, (2) increased mean and axial diffusivity in several peripheral white matter tracts and late‐maturing central white matter tracts, and (3) increased radial diffusivity in peripheral white matter tracts. None of the tracts had reduced fractional anisotropy or diffusivity indices in the PFS group.SignificanceIn this homogeneous, population‐based sample, we found increased fractional anisotropy in early maturing central white matter tracts and increased mean and axial diffusivity with/without increased radial diffusivity in several late‐maturing peripheral white matter tracts 8 years post‐PFS. We propose disruption in white matter maturation secondary to seizure‐induced axonal injury, with subsequent neuroplasticity and microstructural reorganization as a plausible explanation.

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“…Validation frameworks can be divided into three categories: biological phantoms, physical phantoms and numerical simulations. In the first case, the fiber configurations estimated from dMRI are compared with the results of histological or tracerinjection studies [43]- [46], either in vivo or ex vivo, performed on the same biological sample. In particular, an emerging technique called three-dimensional Polarized Light Imaging (3D-PLI) [47] is capable of providing the directionality of the axons in postmortem human brains at ultra-high resolution, i.e.…”

mentioning

confidence: 99%

Quantitative Comparison of Reconstruction Methods for Intra-Voxel Fiber Recovery From Diffusion MRI

Daducci¹,

Canales‐Rodríguez²,

Descoteaux³

et al. 2014

IEEE Trans. Med. Imaging

150

180

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Abstract-Validation is arguably the bottleneck in the diffusion MRI community. This paper evaluates and compares 20 algorithms for recovering the local intra-voxel fiber structure from diffusion MRI data and is based on the results of the "HARDI reconstruction challenge" organized in the context of the "ISBI 2012" conference. Evaluated methods encompass a mixture of classical techniques well-known in the literature such as Diffusion Tensor, Q-Ball and Diffusion Spectrum imaging, algorithms inspired by the recent theory of compressed sensing and also brand new approaches proposed for the first time at this contest. To quantitatively compare the methods under controlled conditions, two datasets with known ground-truth were synthetically generated and two main criteria were used to evaluate the quality of the reconstructions in every voxel: correct assessment of the number of fiber populations and angular accuracy in their orientation. This comparative study investigates the behavior of every algorithm with varying experimental conditions and highlights strengths and weaknesses of each approach.

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Quantitative Histological Validation of Diffusion MRI Fiber Orientation Distributions in the Rat Brain

Cited by 164 publications

References 52 publications

Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance

Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance

Long‐term white matter tract reorganization following prolonged febrile seizures

Quantitative Comparison of Reconstruction Methods for Intra-Voxel Fiber Recovery From Diffusion MRI

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Quantitative Histological Validation of Diffusion MRI Fiber Orientation Distributions in the Rat Brain

Cited by 164 publications

References 52 publications

Catch-up Alveolarization in Ex-Preterm Children. Evidence from 3He Magnetic Resonance

Catch-up Alveolarization in Ex-Preterm Children. Evidence from 3He Magnetic Resonance

Long‐term white matter tract reorganization following prolonged febrile seizures

Quantitative Comparison of Reconstruction Methods for Intra-Voxel Fiber Recovery From Diffusion MRI

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Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance

Catch-up Alveolarization in Ex-Preterm Children. Evidence from ³He Magnetic Resonance