Quantitative Gas Liquid Chromatographic Determination of Ethinyl Estradiol

Light Stability of Norethindrone and Ethinyl Estradiol Formulated with FD&C Colorants

“…Erythrosine is a fluorescein derivative and is thus in a class of compounds that are known sensitizing agents for photooxygenation and photorearrangement reactions (8,9). The disodium salt of 1 -p-sulfophenylazo-2-naphthol-6-sulfonic acid is, however, an azo dye and not considered a sensitizer for such reactions.…”

Validation of Methanol-Sulfuric Acid Colorimetry as a Stability Assay Method for Quinestrol by Comparison with a Gas Chromatographic Procedure

“…The unidentified peaks noted were the same as in the lower base concentration experiment. Talmage et al (4) and Boughton and his co-workers (5) used estrone as the internal standard for gas chromatographic determination of ethinyl estradiol. It would appear that this is a poor choice, for the estrone is both a synthesis precursor and a possible degradation product.…”

Selective Colorimetric Determination of Ethynodiol Diacetate in Oral Estrogen-Progestin Combination

“…Many analytical techniques such as gas chromatography (1-9, thin-layer chromatography (TLC) (1)(2)(3)(4)(5)(6), UV spectrophotometry (4-6), fluorometry (5,7,8), and colorimetry (5,(8)(9)(10) have been used for the determination of the estrogen component (ethinylestradiol or mestranol) present in the estrogen-progestin tablets and the procedures are abundantly described in literature.…”