Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy

Adcock, Jane; Wise, Richard G.; Oxbury, J. M.; Oxbury, Susan; Matthews, Paul M.

doi:10.1016/s1053-8119(02)00013-7

Cited by 304 publications

(268 citation statements)

References 61 publications

Supporting

Mentioning

240

Contrasting

Unclassified

Order By: Relevance

“…Post-operative epilepsy patients also may have a significantly different temporo-frontal distribution of activation compared to controls. The results of this study on postoperative patients, in combination with recently published results on pre-operative patients (Adcock et al, 2003), suggest that resection of the left anterior temporal lobe results in interhemispheric redistribution effects for cerebral language organization, involving homologuous brain areas contralateral to the resected side.…”

Section: Discussionsupporting

confidence: 72%

“…Moreover, only a limited number of patients (one LTL and one RTL) had a seizure onset before the age of 5, being the critical age to allow early language reorganisation. Adcock et al (2003) have recently demonstrated that the LI values for preoperative LTL patients are lower than the RTL patients and controls. The preoperative LTL patient group, however, included 4 out of 12 patients with an atypical (one right and three bilateral) language lateralization according to the IAP in the contrary to the RTL group which included only patients with a left lateralized IAP result.…”

Section: Discussionmentioning

confidence: 96%

“…The preoperative LTL patient group, however, included 4 out of 12 patients with an atypical (one right and three bilateral) language lateralization according to the IAP in the contrary to the RTL group which included only patients with a left lateralized IAP result. Reanalysing the study by Adcock et al (2003) shows that there are no differences in terms of LI values between pre-operative LTL and RTL patients when only patients with a lefthemispheric language dominance according to the IAP were selected. Because of the pre-operative language lateralization criterion and the almost perfect agreement between fMRI and IAP language lateralization reported in many studies (Binder et al, 1996;Yetkin et al, 1998;Lehéricy et al, 2000;Rutten et al, 2002a,b;Spreer et al, 2002;Adcock et al, 2003;Woermann et al, 2003) for RTL and LTL patients, the interhemispheric redistributions effects found in this study are more likely to occur due to the surgical intervention.…”

Section: Discussionmentioning

confidence: 97%

“…The authors explained the plasticity effect by the assumption of a pre-existing bilateral language network that is inhibited by preferential left activation in the normal healthy situation. Shifts in brain activation patterns are also found in TLE patients with lesions at or near the language areas (Adcock et al, 2003;Springer et al, 1999).…”

Section: Introductionmentioning

confidence: 89%

“…Until now, extremely good correlations have been published between fMRI and the IAP, especially for epilepsy patients with a typical (i.e. left dominant) language representation (Binder et al, 1996;Yetkin et al, 1998;Lehéricy et al, 2000;Rutten et al, 2002a,b;Spreer et al, 2002;Adcock et al, 2003;Woermann et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

View full text Add to dashboard Cite

Objective: To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. Methods: Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. Results: For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and postoperative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. * Corresponding author. Backes et al. / Epilepsy Research 66 (2005) [1][2][3][4][5][6][7][8][9][10][11][12] Conclusion: The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologuous brain areas, are suggested to contribute to the cerebral reorganisation of language function.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

View full text Add to dashboard Cite

show abstract

Evidence-Based Practice

Baxendale

Thompson²,

Duncan³

2008

Arch Neurol

View full text Add to dashboard Cite

Naming fMRI predicts the effect of temporal lobe resection on language decline

Trimmel

Graan

Gonzálvez

et al. 2019

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective: To develop language functional MRI (fMRI) methods that accurately predict postsurgical naming decline in temporal lobe epilepsy (TLE). Methods: Forty-six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory naming and picture naming, both with active baseline conditions) and one covert task (verbal fluency). Clinical naming performance was assessed preoperatively and 4 months following anterior temporal lobe resection. Preoperative fMRI activations were correlated with postoperative naming decline. Individual laterality indices (LI) were calculated for temporal (auditory and picture naming) and frontal regions (verbal fluency) and were considered as predictors of naming decline in multiple regression models, along with other clinical variables (age at onset of seizures, preoperative naming scores, hippocampal volume, age). Results: In left TLE patients, activation of the left posterior inferior temporal gyrus during auditory naming and activation of left fusiform gyrus during picture naming were related to greater postoperative naming decline. Activation LI were the best individual predictors of naming decline in a multivariate regression model. For picture naming, an LI of higher than 0.34 gave 100% sensitivity and 92% specificity (positive predictive value (PPV) 91.6%). For auditory naming, a temporal lobe LI higher than 0.18 identified all patients with a clinically significant naming decline with 100% sensitivity and 58% specificity (PPV: 58.3%). No effect was seen for verbal fluency. Interpretation: Auditory and picture naming fMRI are clinically applicable to predict postoperative naming decline after left temporal lobe resection in individual patients, with picture naming being more specific. 2186

show abstract

Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy

Cited by 304 publications

References 61 publications

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

Evidence-Based Practice

Naming fMRI predicts the effect of temporal lobe resection on language decline

Contact Info

Product

Resources

About