“…The clinical liver injury diagnostic methods are generally not suitable for the early assessment of liver injury. Since the pathogenesis of HIRI is closely related to oxidative stress disorder, − for example, previous evidence suggests that H 2 O 2 can activate the G-protein to destroy the junctional complex and enhance ischemia-reperfusion injury . In addition, distinct from other highly ROS (e.g., O 2 •– , • OH, ONOO – ) that are partially involved in ischemic damage, the stable H 2 O 2 is diffusible across the cell membrane, making it the main ROS that exacerbates ischemia-reperfusion injury.…”