Quantitative flow ratio for functional evaluation of in-stent restenosis

Liontou, Catherine; Mejía‐Rentería, Hernán; Lauri, Francesco; Goto, Sonoka; Lee, Hyun-Jong; Nakayama, Masafumi; Quirós, Alicia; Macaya, Fernando; Gonzalo, Nieves; Núñez‐Gil, Iván J.; Salinas, Pablo; Trigo, María Del; Escaned, Javier

doi:10.4244/eij-d-18-00955

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…In the acute setting of STEMI and NSTEMI, QFR measurement in non-culprit vessels appeared to be feasible, reliable, and showed a good diagnostic performance compared to QFR itself and FFR performed in a staged procedure [ 78 – 83 ]. QFR proved also to have an equivalent diagnostic efficiency in assessing functional relevance of in-stent restenosis as in de novo stenosis, though it did not appear a useful tool in predicting in-stent late lumen loss [ 84 , 85 ].…”

Section: Specific Clinical Settings: Prior MI Severe Aortic Stenosis ...mentioning

confidence: 99%

Angiography-Based Fractional Flow Reserve: State of the Art

et al. 2022

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Purpose of Review Three-dimensional quantitative coronary angiography-based methods of fractional flow reserve (FFR) derivation have emerged as an appealing alternative to conventional pressure-wire-based physiological lesion assessment and have the potential to further extend the use of physiology in general. Here, we summarize the current evidence related to angiography-based FFR and perspectives on future developments. Recent Findings Growing evidence suggests good diagnostic performance of angiography-based FFR measurements, both in chronic and acute coronary syndromes, as well as in specific lesion subsets, such as long and calcified lesions, left main coronary stenosis, and bifurcations. More recently, promising results on the superiority of angiography-based FFR as compared to angiography-guided PCI have been published. Summary Currently available angiography -FFR indices proved to be an excellent alternative to invasive pressure wire-based FFR. Dedicated prospective outcome data comparing these indices to routine guideline recommended PCI including the use of FFR are eagerly awaited.

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Section: Specific Clinical Settings: Prior MI Severe Aortic Stenosis ...mentioning

confidence: 99%

Angiography-Based Fractional Flow Reserve: State of the Art

et al. 2022

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“…Quantitative flow ratio (QFR) is an innovative implement of computational physiology based on three-dimensional (3D) reconstruction of anatomy and hemodynamic simulation, which has shown excellent correlation and agreement with invasive wire-based fractional flow reserve (FFR) [ 14 – 16 ]. Previous studies have demonstrated that QFR can be used to evaluate patients with ISR [ 17 , 18 ], and post-procedural QFR had the ability to predict future clinical vessel-oriented composite endpoints (VOCE) [ 19 ]. On this basis, several studies have recently explored the ability of conventional 3D-based QFR to predict the clinical outcome of ISR treated with DCB [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of post-procedural μQFR for drug-coated balloons in the treatment of in-stent restenosis

et al. 2023

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“…This new physiology assessment tool does not require intracoronary instrumentation and it can evaluate the functional relevance of coronary stenoses rapidly, online and o ine, nevertheless, its diagnostic performance has not been so far adequately evaluated in the setting of NSTE-ACS. Although several trials that assessed QFR diagnostic performance in comparison to other physiology indices have included patients with NSTE-ACS [19][20][21], prospective studies in this speci c subgroup of patients are limited [22].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of Quantitative Flow Ratio in Non-ST Elevation Acute Coronary Syndromes in Comparison to Non-Hyperemic Pressure Ratios. A prospective study

Liontou

Kalogera

Oikonomou

et al. 2023

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Purpose Quantitative Flow Ratio (QFR) is a new angiography-based coronary physiology tool aimed to evaluate functional relevance of intermediate coronary lesions. Aim of the study is to assess diagnostic performance of QFR in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) in comparison to currently used non-hyperaemic pressure ratios (NHPRs). Methods In this prospective, single-centre study, coronary physiology of intermediate coronary stenoses of non-culprit vessels in patients presenting with NSTE-ACS was evaluated using NHPRs (iFR, DFR or RFR). Subsequently, QFR was computed offline by a QFR analyst blinded to the NHPR results. Diagnostic performance of QFR was assessed in comparison to NHPRs as reference standard. Results A total of 60 vessels with intermediate coronary stenoses was investigated. The NHPRs were used as follows: RFR 38%, DFR 47% and iFR 15% of the cases. The NHPR result was positive, showing significant lesion, in 19 cases. A significant correlation was found between NHPR and QFR (r = 0.84, p < 0.001). Classification agreement of the two methods (95%) and diagnostic performance of QFR in comparison to NHPR (AUC: 0.962 [0.914–1.00]) were both high. Sensitivity, specificity, positive and negative predictive value of QFR in comparison to NHPR were 84.2%, 100%, 100% and 93.2% respectively. Conclusion QFR has high diagnostic performance in detecting functionally significant lesions of non-culprit arteries in patients with NSTE-ACS and multivessel disease. Due to its high negative predictive value, it can be used to safely avoid unnecessary invasive physiological assessment of these lesions.

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Quantitative flow ratio for functional evaluation of in-stent restenosis

Cited by 10 publications

References 5 publications

Angiography-Based Fractional Flow Reserve: State of the Art

Angiography-Based Fractional Flow Reserve: State of the Art

Prognostic value of post-procedural μQFR for drug-coated balloons in the treatment of in-stent restenosis

Diagnostic Performance of Quantitative Flow Ratio in Non-ST Elevation Acute Coronary Syndromes in Comparison to Non-Hyperemic Pressure Ratios. A prospective study

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