Quantitative evaluation of vertebral marrow adipose tissue in postmenopausal female using MRI chemical shift-based water–fat separation

Assessment of whole spine vertebral bone marrow fat using chemical shift‐encoding based water‐fat MRI

“…In the context of osteoporosis, water-fat imaging-based vertebral bone marrow fat fraction was inversely correlated with BMD. [14][15][16] Furthermore, water-fat imaging based bone marrow fat fraction increased after chemotherapy and radiation therapy, thus detecting chemotherapy and radiation-induced bone marrow damage.…”

“…12,13 Vertebral bone marrow PDFF has been reported to be inversely correlated with BMD. [14][15][16] Furthermore, water-fat imaging has been successfully applied to detect chemotherapy and radiation-induced bone marrow damage.…”

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

“…MFF percentage was defined as: MFF ¼ PV lipid /(PV lipid þ PV water ) Â 100, where PV lipid and PV water represent pixel values averaged across the total number of slices sampled in the fat-only/ water-only series. 19 Two radiologists experienced in musculoskeletal radiology independently drew the ROI. To assess the repeatability of MFF measurements, we obtained the coefficient of variation using duplicate measurements from 10 rats that were taken out and repositioned into the same MRI settings.…”

Osteoporosis: what the clinician needs to know?

“…Basing on the assumption that during osteoporosis there is an adipose involution of bone marrow, different methods have been proposed to quantify the amount of fat fraction, such as T1-weighted images, the Dixon method (which provide fat and water images), diffusion weighted imaging (DWI) or metabolic evaluation using proton magnetic resonance spectroscopy ( 1 H-MRS) (36)(37)(38)(39)(40); perfusion studies have also demonstrated a reduced blood supply to the bone marrow, in course of osteoporosis (39,41). Moreover, some research studies have shown that HR imaging sequences, scanning peripheral sites such as tibia or calcaneus, may be helpful in the evaluation of bone microstructure and correlate with spinal BMD (42,43).…”