Quantitative Evaluation of Phase Retardation in Filtering Blebs Using Polarization-Sensitive Optical Coherence Tomography

Fukuda, Shin–ichi; Fujita, Akari; Kasaragod, Deepa; Ueno, Yuta; Hoshi, Sujin; Kishino, Genichiro; Beheregaray, Simone; Yasuno, Yoshiaki; Oshika, Tetsuro

doi:10.1167/iovs.16-19548

Cited by 12 publications

(11 citation statements)

References 35 publications

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“…Phase retardation images might be effective for evaluating mild fibrotic changes during the early stage after surgery, as previously reported. This finding is consistent with our previous report that phase retardation images provide an estimated prognostic value for filtering bleb function during the early stage after glaucoma surgery 18 , 19 .…”

Section: Resultssupporting

confidence: 93%

“…A large hyporeflective area was considered to represent a small amount fibrosis, which correlated with the function of the blebs 12 . The current study and previous studies revealed that the reflectivity on intensity images did not always correlate with tissue fibrosis 18 , 19 , 22 . We recently reported that PS-OCT was useful for evaluating bleb fibrosis after glaucoma filtration surgery using two types of birefringent imaging: phase retardation and local birefringence 18 , 19 , 22 .…”

Section: Discussioncontrasting

confidence: 47%

“…We previously reported that phase retardation imaging detected early changes in fibrotic scar tissue and provided a prognostic value for filtering bleb function during the early stage after glaucoma surgery 18 , 19 . In the current study, nine cases were consecutively observed during the early postoperative period (mean 3.4 ± 1.2 months after surgery).…”

Section: Resultsmentioning

confidence: 99%

“…We previously reported a high correlation between phase retardation alterations and bleb function in a large-scale study 18 , 19 . Phase retardation also allowed estimation of the prognostic value for the filtering bleb function during the early stage after glaucoma surgery 18 .…”

Section: Introductionmentioning

confidence: 90%

“…PS-OCT can also obtain intensity images simultaneously, which perfectly co-register with the phase retardation and local birefringence images. Phase retardation images provide the accumulated polarization effect along the depth 16 , 18 , 19 . Local birefringence is a truly depth-resolved polarization quantity 20 – 22 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography

Fukuda

Fujita

Kasaragod

et al. 2018

Sci Rep

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Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can noninvasively detect fibrotic area in blebs after glaucoma surgery. Evaluation of scar fibrosis in blebs is important not only for predicting bleb function, but also for planning revision trabeculectomy. Herein, we characterize the intensity, phase retardation, and local birefringence images of blebs using PS-OCT. A total of 85 blebs from 85 patients who had undergone trabeculectomy were examined. Both phase retardation and local birefringence images detected fibrotic changes in blebs after glaucoma surgery. Phase retardation images detected slight fibrotic change during the early stage after surgery, whereas local birefringence images showed localized fibrotic tissue. There are two main patterns of local birefringence image changes in blebs: plate-like birefringence changes and diffuse changes. The area of plate-like birefringence change was significantly larger in poorly functioning blebs and is thus correlated with bleb function. These data suggest that the plate-like fibrotic change evaluation by PS-OCT may be useful not only for noninvasive evaluation of fibrotic scar tissue in blebs, but also for developing strategies for revision trabeculectomy.

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Section: Resultssupporting

confidence: 93%