Quantitative evaluation of liver function with T1 relaxation time index on Gd‐EOB‐DTPA‐enhanced MRI: Comparison with signal intensity‐based indices

Kamimura, Kiyohisa; Fukukura, Yoshihiko; Yoneyama, T.; Takumi, Koji; Tateyama, Akihiro; Umanodan, Aya; Shindo, Toshikazu; Kumagae, Yuichi; Ueno, S.; Koriyama, Chihaya; Nakajo, Masayuki

doi:10.1002/jmri.24443

Cited by 61 publications

(39 citation statements)

References 24 publications

(44 reference statements)

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“…Two recent studies by Kamimura et al [21] and Ding et al [20] have assessed the utility of T1 relaxometry before and after gadoxetic acid administration for the assessment of liver cirrhosis and liver function using a 3D-DFA technique at a 3 T (n = 99 patients) and 1.5 T (n = 100 patients) system respectively showing that this technique has potential to serve as an MRI-based liver function test. Compared to these studies, our study provides in-vitro validation of T1 relaxation values and information on intra-patient variability of T1 values in the largest published series of patients.…”

Section: Discussionmentioning

confidence: 98%

“…To date, few studies have examined the ability of gadoxetic acid T1 relaxometry for diagnosing liver fibrosis and for prediction of liver Magnetic Resonance Imaging 33 (2015) 1075-1082 function [18][19][20][21] showing good results for assessment of severity of liver cirrhosis with significant differences in T1 relaxation times of the liver after gadoxetic acid administration between patients with normal liver function and patients with Child-Pugh A, B, and C cirrhosis. These data showed that this technique might provide suitable parameters for detecting and characterizing severity of cirrhosis.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

Besa

Bane

Jajamovich

et al. 2015

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

Besa

Bane

Jajamovich

et al. 2015

Magnetic Resonance Imaging

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“…Several studies have shown the relationship between liver function and T 1 relaxation time. Kamimura et al showed that the reduction rate of the T 1 relaxation time of liver parenchyma could distinguish Child-Pugh A and B from normal liver better than the relative enhancement of the liver using SI [23]. In their study, the SI of paravertebral muscle and the spleen were used as the SI reference for liver parenchyma, but the scale and rescale slopes were not used.…”

Section: Discussionmentioning

confidence: 99%

Optimizing signal intensity correction during evaluation of hepatic parenchymal enhancement on gadoxetate disodium-enhanced MRI: Comparison of three methods

Onoda

Hyodo

Murakami

et al. 2015

European Journal of Radiology

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a b s t r a c tObjective: To compare signal intensity (SI) correction using scale and rescale slopes with SI correction using SIs of spleen and muscle for quantifying multiphase hepatic contrast enhancement with Gd-EOB-DTPA by assessing their correlation with T 1 values generated from Look-Locker turbo-field-echo (LL-TFE) sequence data (ER-T 1 ). Materials and methods: Thirty patients underwent Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in this prospective clinical study. For each patient, breath-hold T 1 -weighted fat-suppressed three-dimensional (3D) gradient echo sequences (e-THRIVE) were acquired before and 2 (first phase), 10 (second phase), and 20 min (third phase) after intravenous Gd-EOB-DTPA. Look-Locker turbo-fieldecho (LL-TFE) sequences were acquired before and 1.5 (first phase), 8 (second phase), and 18 min (third phase) postcontrast. The liver parenchyma enhancement ratios (ER) of each phase were calculated using the SI from e-THRIVE sequences (ER-SI) and the T 1 values generated from LL-TFE sequence data (ER-T 1 ) respectively. ER-SIs were calculated in three ways: (1) comparing with splenic SI (ER-SI-s), (2) comparing with muscle SI (ER-SI-m), (3) using scale and rescale slopes obtained from DICOM headers (ER-SI-c), to eliminate the effects of receiver gain and scaling. For each of the first, second and third phases, correlation and agreement were assessed between each ER-SI and ER-T 1 . Results: In the first phase, all ER-SIs correlated weakly with ER-T 1 . In the second and third phases, ER-SI-c showed a stronger linear correlation with ER-T 1 (r 2 = 0.71-0.72, p < 0.01) than did ER-SI-s (r 2 = 0.37-0.39, p < 0.01) or ER-SI-m (r 2 = 0.30-0.41, p < 0.01). Conclusion: SI correction using scale and rescale slopes from DICOM data is the most acceptable algorithm for evaluating delayed-phase Gd-EOB-DTPA hepatic enhancement.

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“…Such studies have demonstrated changes in T 1 -based quantification in the presence of disease and correlations with model for end-stage liver disease (MELD) scores. 39,40 …”

Section: Approaches To Mr Haemodynamic Imaging In the Livermentioning

confidence: 99%

Vascular assessment of liver disease—towards a new frontier in MRI

Chouhan

Lythgoe

Mookerjee

et al. 2016

BJR

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Complex haemodynamic phenomena underpin the pathophysiology of chronic liver disease. Non-invasive MRI-based assessment of hepatic vascular parameters therefore has the potential to yield meaningful biomarkers for chronic liver disease. In this review, we provide an overview of vascular sequelae of chronic liver disease amenable to imaging evaluation and describe the current supportive evidence, strengths and the limitations of MRI methodologies, including dynamic contrast-enhanced, dynamic hepatocyte-specific contrast-enhanced, phase-contrast, arterial spin labelling and MR elastography in the assessment of hepatic vascular parameters. We review the broader challenges of quantitative hepatic vascular MRI, including the difficulties of motion artefact, complex post-processing, long acquisition times, validation and limitations of pharmacokinetic models, alongside the potential solutions that will shape the future of MRI and deliver this new frontier to the patient bedside.

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Quantitative evaluation of liver function with T1 relaxation time index on Gd‐EOB‐DTPA‐enhanced MRI: Comparison with signal intensity‐based indices

Abstract: The T1 relaxation time index has the potential to serve as an MRI-based liver function test, and is most strongly correlated with ICG clearance among the Gd-EOB-DTPA MRI-based indices investigated.

Cited by 61 publications

References 24 publications

3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function

Optimizing signal intensity correction during evaluation of hepatic parenchymal enhancement on gadoxetate disodium-enhanced MRI: Comparison of three methods

Vascular assessment of liver disease—towards a new frontier in MRI

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