Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere’s disease

Guo, Ping; Sun, Wenfang; Shi, Shengjun; zhang, Fang; Wang, Jiali; Wang, Wuqing

doi:10.1007/s00405-018-05267-7

Cited by 18 publications

(14 citation statements)

References 30 publications

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“…28 Our data also suggested that there is no significant correlation between CP value and the grades of endolymphatic hydrops in the cochlea and vestibule, which is consistent with previous studies. 29 However, Guo et al found that the abnormal CP value in patients with an obvious vestibular hydrops was higher than that in patients with mild or no vestibular hydrops, suggesting that CP value is affected by vestibular hydrops, 30 which was in contrast to what we found in the present study. The difference of the results between these two previous studies and our study may be due to the difference in the selection of the injected contrast agents.…”

Section: Discussioncontrasting

confidence: 99%

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease

et al. 2020

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Objectives The purpose of this study was to investigate the grades of endolymphatic hydrops determined by gadolinium‐contrast magnetic resonance (MR) and correlation to the clinical features in patients with Meniere disease. Study Design Prospective study. Methods A total of 24 patients suffering from unilateral Meniere disease with either definite or probable clinical diagnosis were included. The duration of vertigo, duration of tinnitus, duration of vertigo attacks, hearing thresholds, and canal paresis (CP) value of caloric tests were assessed. Three‐dimensional fluid‐attenuated inversion recovery magnetic resonance imaging (MRI) was performed 4 hours after intravenous injection of double dose of gadobutrol (Gd) to show endolymph and perilymph, and the grades of endolymphatic hydrops were measured. Additionally, the correlation between clinical features and the grades of endolymphatic hydrops of cochlea and vestibular were evaluated. Results Different grades of the endolymphatic hydrops in the impaired ear were revealed by MRI. The Spearman correlation showed a strong correlation between the hearing thresholds of low, middle, and high tone and the grades of cochlea and vestibular hydrops (P < .05); However, no significant correlation between the duration of vertigo, duration of tinnitus, duration of vertigo attacks, CP value, and endolymphatic hydrops was determined (P > .05). Conclusion By visualizing the endolymph and perilymph of inner ear in patients with Meniere disease assisted with intravenous injection of double doses of Gd, the grades of endolymphatic hydrops could be assessed. As a result, the grades of endolymphatic hydrops in patients with Meniere disease can be used to predict the level of hearing impairment. Level of Evidence 4 Laryngoscope, 131:E144–E150, 2021

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Section: Discussioncontrasting

confidence: 99%

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease

et al. 2020

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“…Furthermore, none of these studies found a significant correlation between MRI and otolithic function. Nevertheless, Guo et al have reported that cVEMP AR was higher in MD patients with severe vestibular hydrops than in patients without vestibular hydrops . So far, only one study assessed the relationship between cVEMP and SH on MRI, and no correlation was found .…”

Section: Discussionmentioning

confidence: 97%

Relationship between video head impulse test, ocular and cervical vestibular evoked myogenic potentials, and compartmental magnetic resonance imaging classification in menière's disease

et al. 2019

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Objectives/Hypothesis Currently, it is possible to assess in vivo the morphology of each compartment of the endolymphatic spaces 4 hours after an intravenous administration of gadolinium on magnetic resonance imaging (MRI). The aim of this study was to assess the correlation between otolithic and ampullar functions (cervical vestibular evoked myogenic potential [cVEMP], ocular vestibular evoked myogenic potential [oVEMP], video head impulse test [VHIT]) and delayed inner ear MRI based on a compartmental, anatomically based classification that included the cochlea, the saccule, the utricle, and the ampullas. Study Design Retrospective case–control study. Methods In this retrospective study, we performed three‐dimensional fluid‐attenuated inversion recovery sequences with delayed acquisition in 26 healthy subjects and 31 definite Menière's disease (MD) patients. Each subject was then graded on MRI on the basis on cochlear, saccular, utricular, and ampullar hydrops in MD patients. All patients underwent pure‐tone audiometry, VHIT, cVEMP, and oVEMP testing. Results Cochlear, saccular, utricular, and ampullar hydrops were found on MRI in 88%, 91%, 50%, and 8.5% respectively. We found no significant correlation between the presence of saccular hydrops versus cVEMP, utricular hydrops versus oVEMP, and ampullar hydrops versus VHIT. However, the severity of endolymphatic hydrops on MRI was correlated to the degree of hearing loss. Conclusions We proposed a compartmental, anatomically based classification for endolymphatic hydrops on MRI, which included the whole vestibular compartment. Using this classification, we observed increasing morphological changes as the disease evolved, affecting first the saccule, then the utricle, and finally the ampullas. The severity of vestibular endolymphatic hydrops is only correlated to hearing loss severity. Level of Evidence 3 Laryngoscope, 130:E444–E452, 2020

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“…In recent years, it has become possible to use magnetic resonance imaging (MRI) to visualize hydrops in the cochlea and vestibule. 68 In some studies, a correlation between AC cVEMP abnormality and the degree of vestibular (as opposed to cochlear) endolymphatic hydrops has been shown, [69][70][71] though other studies have not reproduced this effect. 72 A correlation between hydrops severity and audiological tests has also been demonstrated, and these relationships may improve in the future with improvements in MRI technology.…”

Section: Superior Canal Dehiscence Syndromementioning

confidence: 99%

Vestibular-Evoked Myogenic Potential Testing in Vestibular Localization and Diagnosis

et al. 2020

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Vestibular-evoked myogenic potentials (VEMPs) are short-latency, otolith-dependent reflexes recorded from the neck and eye muscles. They are widely used in neuro-otology clinics as tests of otolith function. Cervical VEMPs are recorded from the neck muscles and reflect predominantly saccular function, while ocular VEMPs are reflexes of the extraocular muscles and reflect utricular function. They have an important role in the diagnosis of superior canal dehiscence syndrome and provide complementary information about otolith function that is useful in the diagnosis of other vestibular disorders. Like other evoked potentials, they can provide important localizing information about lesions that may occur along the VEMP pathway. This review will describe the VEMP abnormalities seen in common disorders of the vestibular system and its pathways.

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Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere’s disease

Cited by 18 publications

References 30 publications

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease

Relationship between video head impulse test, ocular and cervical vestibular evoked myogenic potentials, and compartmental magnetic resonance imaging classification in menière's disease

Vestibular-Evoked Myogenic Potential Testing in Vestibular Localization and Diagnosis

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