Quantitative evaluation of diffusion-weighted imaging techniques for the purposes of radiotherapy planning in the prostate

Liney, Gary; Holloway, Lois; Harthi, T M Al; Sidhom, Mark; Moses, Daniel; Juresic, Ewa; Rai, Roshika; Manton, David J.

doi:10.1259/bjr.20150034

Cited by 37 publications

(31 citation statements)

References 22 publications

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“…Although rsEPI may reduce susceptibility‐induced distortions in DW MRI of the prostate compared with ssEPI, in this study the artifacts observed with ssEPI were mostly retained with rsEPI. Additionally, ADC values obtained by DW rsEPI largely deviated from those measured with either STEAM or ssEPI.…”

Section: Discussionmentioning

confidence: 67%

“…Second, although limited to two patients, the present observations suggest that DW STEAM images and ADC maps may lead to a more accurate anatomical delineation of prostate lesions than possible with EPI. Apart from the actual diagnostic value, this property also renders DW STEAM MRI a promising choice for radiotherapy planning in the prostate . Third, DW STEAM MRI may enhance diagnostic reliability by eliminating the risk of misinterpretations of susceptibility‐induced signal alterations.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the inherent sensitivity of EPI to magnetic field inhomogeneities and susceptibility differences may seriously compromise diagnostic information in prostate MRI . Although readout‐segmented EPI (rsEPI) of the prostate has been shown to partly ameliorate the influence of susceptibility differences, it may still lead to relevant image distortions …”

Section: Introductionmentioning

confidence: 99%

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Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

et al. 2019

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Funding informationDeutsche Krebshilfe e.V.The aim of this study was to develop and evaluate a clinically feasible approach to diffusion-weighted (DW) MRI of the prostate without susceptibility-induced artifacts.The proposed method relies on an undersampled multi-shot DW turbo-STEAM sequence with rotated radial trajectories and a multi-step inverse reconstruction with denoised multi-shot phase maps. The total acquisition time was below 6 min for a resolution of 1.4 × 1.4 × 3.5 mm 3 and six directions at b = 600 s mm −2 . Studies of eight healthy subjects and two patients with prostate cancer were performed at 3 T employing an 18-channel body-array coil and elements of the spine coil. The method was compared with conventional DW echo-planar imaging (EPI) of the prostate. The results confirm that DW STEAM MRI avoids geometric distortions and false image intensities, which were present for both single-shot EPI (ssEPI) and readoutsegmented EPI, particularly near the intestinal wall of the prostate. Quantitative accuracy of the apparent diffusion coefficient (ADC) was validated with use of a numerical phantom providing ground truth. ADC values in the central prostate gland of healthy subjects were consistent with those measured using ssEPI and with literature data.Preliminary results for patients with prostate cancer revealed a correct anatomical localization of lesions with respect to T 2 -weighted MRI in both mean DW STEAM images and ADC maps. In summary, DW STEAM MRI of the prostate offers clinically relevant advantages for the diagnosis of prostate cancer compared with state-of-theart EPI-based approaches. The method warrants extended clinical trials.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

et al. 2019

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“…The readout-segmented technique with navigated phase correction for DWI has been shown to reduce distortion in other tumour sites. [9][10][11] We have previously shown that this implementation of DWI results in similar geometrically shaped anatomical imaging in the prostate, 12 making it more feasible to correlate with other imaging sequences and/or modalities. However, it has not been evaluated in HNC.…”

Section: Introductionmentioning

confidence: 94%

Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging andR₂*) with¹⁸F-FDG-PET in patients with head and neck cancer treated with radiation therapy

Min

Lee

Lin

et al. 2016

BJR

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F-FDG positron emission tomography (PET) CT performed before and during radiation therapy (RT) in patients with mucosal primary head and neck cancer. Methods: The mean apparent diffusion coefficient (ADC mean ) from DWI (at b 5 50 and 800 s mm 22 ), the mean R 2 * values derived from T 2 *-MRI, and PET metabolic parameters, including maximum standardized uptake value (SUV max ), metabolic tumour volume (MTV) and total lesional glycolysis (TLG) were measured for the primary tumour. Spearman correlation coefficients were calculated to evaluate correlations between ADC mean , R 2 *, SUV max , MTV and TLG. A paired t-test was performed to assess the MRI changes and the slope of serial MRI changes during RT. Results: Pre-treatment scans were performed in 28 patients and mid-treatment scans in 20 patients. No significant correlation was found between ADC mean and either R 2 * values or PET parameters. There were significant negative correlations of R 2 * values with pre-treatment PET parameters but not with mid-RT PET parameters: pre-SUV max (p 5 0.008), pre-MTV (p 5 0.006) and pre-TLG (p 5 0.008). A significant rise in ADC mean was found during the first half (p , 0.001) of RT but not in the second half (p 5 0.215) of the treatment. There was an increase of the ADC mean values of 279.4 [95% confidence interval (95% CI): 210-348] in the first half of the treatment (Weeks 0-3). However, during the second-half period of treatment, the mean ADC value (Weeks 3-6) was 24.0 and the 95% CI (240 to 88) included zero. This suggests that there was no significant change in ADC values during the second half of the treatment. Conclusion: A significant negative correlation was found between pre-treatment R 2 *-MRI and PET parameters. DWI appeared to demonstrate potentially predictable changes during RT. Advances in knowledge: Understanding the correlation and changes that occur with time between potential imaging biomarkers may help us establish the most appropriate biomarkers to consider in future research.

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“…Low ADC values are associated with a poor prognosis [50]. The potential of DWI for integration in target volume definition is furthermore reflected by the fact that it is already in clinical use in radiotherapy of prostate [51,52] or rectal cancer [53], among others [45]. Although a biopsy controlled study in glioma showed that ADC mapping may insufficiently distinguish tumour from peritumoral tissue [54], a recent report introduced the low ADC subvolume, that is not fully covered by the 95 % isodose of prescribed radiation dose, as a significant negative predictor for PFS [55].…”

Section: Advances In Mr Imaging For Radiation Oncology Treatment Planmentioning

confidence: 99%

PET/MRI and brain tumors: focus on radiation oncology treatment planning

Oehlke

Grosu

2016

Clin Transl Imaging

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In brain tumors, imaging by magnetic resonance imaging (MRI) can very accurately visualize anatomy and morphology of healthy and malignant tissue, but neither contrast-enhancing areas in T1-weighted sequences, nor hyperintensities in T2/FLAIR sequences are specific for tumor tissue, especially when considering the manifold alterations resulting from previous treatment. Imaging the biology of tumor tissue by positron emission tomography (PET), therefore, is a highly interesting approach to improve the detection of macroscopic tumor which is the prerequisite for high-precision radiotherapy treatment planning. This review will focus on the benefits of amino acid tracers (L-[methyl-11 C]methionine (MET) and O-(2-[ 18 F]fluoroethyl)-L-tyrosine (FET)) in neurooncology and their implementation in radiation oncology. Furthermore, a brief overview of the current impact of 2-deoxy-2-(18F)fluoro-D-glucose (FDG), nucleic acid analogs, hypoxia tracers, and Somatostatin receptor (SSTR) analogs on radiotherapy planning in brain tumors is provided. Among advances in multiparametric MRI, Diffusionweighted imaging (DWI) has attracted particular attention since it can predict prognosis, as well as indicate response to treatment and has already been introduced into target volume definition for radiotherapy of various cancers (e.g., prostate and rectal cancer). Additionally, advances in MR spectroscopy (MRS) are mentioned. Finally, these findings will be discussed concerning their influence on current aspects of integrated PET/MR hybrid imaging.

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Quantitative evaluation of diffusion-weighted imaging techniques for the purposes of radiotherapy planning in the prostate

Abstract: This work will be of interest to the increasing number of centres wanting to incorporate quantitative DWI in a clinical setting.

Cited by 37 publications

References 22 publications

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging andR₂*) with¹⁸F-FDG-PET in patients with head and neck cancer treated with radiation therapy

PET/MRI and brain tumors: focus on radiation oncology treatment planning

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Quantitative evaluation of diffusion-weighted imaging techniques for the purposes of radiotherapy planning in the prostate

Abstract: This work will be of interest to the increasing number of centres wanting to incorporate quantitative DWI in a clinical setting.

Cited by 37 publications

References 22 publications

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

Diffusion‐weighted MRI of the prostate without susceptibility artifacts: Undersampled multi‐shot turbo‐STEAM with rotated radial trajectories

Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging andR2*) with18F-FDG-PET in patients with head and neck cancer treated with radiation therapy

PET/MRI and brain tumors: focus on radiation oncology treatment planning

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Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging andR₂*) with¹⁸F-FDG-PET in patients with head and neck cancer treated with radiation therapy