Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths

Panwar, Rahul; Shekhawat, Raghvendra Singh; Shukla, Kamla Kant; Rao, Meenakshi; Rathore, Mohini; Kanchan, Tanuj

doi:10.1016/j.jflm.2023.102559

Cited by 1 publication

(1 citation statement)

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“…In addition, researchers have utilized the ELISA method to overcome challenges in forensic practice, such as the cause of death in 'negative autopsies' and PMI estimation. Panwar R. et al [69] employed the ELISA method to identify TNF-α and IL-3 as two reliable biomarkers for detecting mast cells, which could increase under a prolonged hypoxia condition. And this optimization method can help forensic pathologists to differentiate fatal asphyxia decedents easily from other causes of death.…”

Section: Enzyme-linked Immunosorbent Assay (Elisa) and Western Blotmentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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It is well known that proteins are important bio-macromolecules in human organisms, and numerous proteins are widely used in the clinical practice, whereas their application in forensic science is currently limited. This limitation is mainly attributed to the postmortem degradation of targeted proteins, which can significantly impact final conclusions. In the last decade, numerous methods have been established to detect the protein from a forensic perspective, and some of the postmortem proteins have been applied in forensic practice. To better understand the emerging issues and challenges in postmortem proteins, we have reviewed the current application of protein technologies at postmortem in forensic practice. Meanwhile, we discuss the application of proteins in identifying the cause of death, and postmortem interval (PMI). Finally, we highlight the interpretability and limitations of postmortem protein challenges. We believe that utilizing the multi-omics method can enhance the comprehensiveness of applying proteins in forensic practice.

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Section: Enzyme-linked Immunosorbent Assay (Elisa) and Western Blotmentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths

Cited by 1 publication

References 31 publications

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

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