Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

Abstract

Background: Tablet manufacturing with direct compression is one of the leading industrial technique that consumes less time, labour and economic also. But the choice of excipients are critical in this case which will allow the drug to get compressed without granulation techniques. Purpose: Aceclofenac is a BCS class II non-steroidal anti-inflammatory drug, which exerts a low oral bioavailability because of low solubility in aqueous medium. The drug also suffers from compressibility and also shows poor tabletibility. Methods: We have attempted to improve tabletability by incorporating titanium dioxide (TiO 2) through kneading and solvent evaporation technique. Results: In the FTIR study revealed that NH and Cl aromatic stretching of aceclofenac has been affected significantly due to binding with TiO 2. DSC thermogram ascertained the partial amorphization of the drug in the formulations. Evaluated tabletability from the area under the applied pressure vs tensile strength curve (AUTC) of A1T1 has shown a poor value in contrast to other formulations.

Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

“…Aceclofenac was dissolved in a minimal amount of acetone and a kneaded mixture was prepared with titanium dioxide at different ratios (Table 1). 17,18 The mass was dried at 50 °C until constant weight and preserved in a desiccator.…”

Effect of Plasticizer on Delivery of Valsartan from Tamarind Gel Based Transdermal Film Formulation

“…The small changes in the peak shifting and intensity are the indication of amorphization of the drug in the film formulations. [15][16][17][18]…”