Quantitative estimation of mebeverine hydrochloride in sustained-release dosage form using an analytical lifecycle management oriented stability-indicating LC method

Panda, Sagar Suman; Bera, Venkata Varaha Ravi Kumar; Sahoo, Padmalaya; Sahu, Biswajit

doi:10.1080/10826076.2018.1500376

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…15,16 Molecularly imprinted polymer (MIP) is a fast-growing field in the applications of drug analysis especially in sensor. 14,23 Also, few of GC-MS, LC-MS and LC methods are reported to describe the stability behavior during the determination of MBH in tablet dosage or other samples. [23][24][25][26] In one of these reported chromatographic methods, MBH was found to be degraded and lose some of it due to using several of stress condition such as oxidative, photolysis, alkali, thermal and acidic.…”

Section: Introductionmentioning

confidence: 99%

“…14,23 Also, few of GC-MS, LC-MS and LC methods are reported to describe the stability behavior during the determination of MBH in tablet dosage or other samples. [23][24][25][26] In one of these reported chromatographic methods, MBH was found to be degraded and lose some of it due to using several of stress condition such as oxidative, photolysis, alkali, thermal and acidic. 26 In addition, great number of the reported methods have shown some drawbacks such as lack of robustness information, lack of peak purity, narrow linearity range, strict monitoring of pH of the mobile phase, non-stability, gradient elution, etc.…”

Section: Introductionmentioning

confidence: 99%

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Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

Wijesooriya¹,

Pandithavidana²

2022

ChChT

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DFT calculations were applied to compare the antioxidant potential of four major catechins present in green tea. The thermodynamic parameters related to three key mechanisms of primary antioxidant action were investigated in detail. Molecular orbital energies, absolute hardness, electronegativity, and electrophilicity index, which contributed to the radical scavenging were also investigated. The radical scavenging potential of each hydroxyl group of these polyphenolic antioxidants were investigated independently.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

Wijesooriya¹,

Pandithavidana²

2022

ChChT

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“…Additionally, most of these methods have been applied for the MEB quantification in dosage forms and spiked biological samples. The literature survey reveals several analytical methods for MEB quantification, such as chromatographic [21,22], GC-MS [23], spectrophotometric [24,25], spectrofluorometric [25,26] and electrochemical methods [27][28][29][30][31][32][33]. Carbon paste electrodes (CPEs) have been applied successfully for MEB quantification either using potentiometric [31] or voltametric techniques [32,33].…”

Section: Introductionmentioning

confidence: 99%

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

et al. 2021

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Herein, a feasible chemical reduction method followed by intensive mixing was applied for the preparation of an attractive material based on graphite studded with cuprous oxide nanoparticle-based cubes (Cu2ONPs–C@G). Transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD) and cyclic voltammetry (CV) were utilized for characterization. Cuprous oxide nanoparticles (Cu2ONPs), with a diameter range mainly distributed from 4 to 20 nm, aggregate to form microcubes (Cu2ONPs–C) with an average diameter of about 367 nm. Paste electrode was prepared using Cu2ONPs–C@G (Cu2ONPs–C@G/PE) for voltametric quantification of the musculotropic antispasmodic drug: mebeverine hydrochloride (MEB). The electrochemical behavior of MEB was studied using CV, and the optimum analytical parameters were investigated using square wave adsorptive anodic stripping voltammetry (SWAdASV). Moreover, density functional theory (DFT) was used to emphasize the ability of MEB to form a complex with Cu2+, confirming the suggested electrochemical behavior of MEB at Cu2ONPs–C@G/PE. With good stability and high reproducibility, SWAdASV of Cu2ONPs–C@G/PE shows successful quantification of MEB over the concentration range of 5.00 × 10−11–1.10 × 10−9 M with lower limit of detection (LOD) and lower limit of quantification (LOQ) values of 2.41 × 10−11 M and 8.05 × 10−11 M, respectively. Finally, accurate quantification of MEB in dosage forms (tablets) and biological fluids (spiked human urine and plasma samples) was achieved using Cu2ONPs-C@G/PE.

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Stability-Indicating LC Method for Estimation of Nimodipine in Dosage Form and Spiked Serum Using Systematized Design of Experiments (DoE) Approach

Panda

Kumar

Mahapatra

2020

Analytical Chemistry Letters

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Quantitative estimation of mebeverine hydrochloride in sustained-release dosage form using an analytical lifecycle management oriented stability-indicating LC method

Cited by 5 publications

References 12 publications

Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

Investigation and Comparison of Antioxidant Potential of Catechins Present in Green Tea: DFT Study

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

Stability-Indicating LC Method for Estimation of Nimodipine in Dosage Form and Spiked Serum Using Systematized Design of Experiments (DoE) Approach

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