Quantitative Endoscopic Ultrasound Elastography: An Accurate Method for the Differentiation of Solid Pancreatic Masses

Iglesias‐García, Julio; Lariño‐Noia, José; Abdulkader, Ihab; Forteza, Jerónimo; Domínguez‐Muñoz, J. Enrique

doi:10.1053/j.gastro.2010.06.059

Cited by 275 publications

(248 citation statements)

References 30 publications

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“…However, there is no consensus where to set reference area for the pancreas instead of fat around the mammary gland for the breast. Some investigators set reference area on non tumorous area inside pancreatic parenchyma [33,34] , and the other investigators set reference area on red area around the pancreas which was estimated as fat [35,36] (Figure 4) . However, there is no evidence if red area around pancreas is really fat.…”

Section: Us-elastography -Shear Wave Elastograhymentioning

confidence: 99%

“…Itokawa et al [34] subjected 72 ductal adenocar cinomas and 7 tumor forming pancreatitis, and reported that strain ratio was significantly higher in ductal adenocarcinomas compared to that in tumor forming pancreatitis (39.08 ± 20.54 vs 23.66 ± 12.65, P < 0.05). Iglesias Garcia et al [35] subjected 86 pancreatic tumors including 49 ductal adenocarcinomas, 27 tumor forming pancreatitis, 6 endocrine carcinomas, and 2 metastatic carcinomas. They reported when cutoff of strain ratio optimal for distinguishing malignancy from benignancy was determined as 6.04, sensitivity and specificity were 100% and 92.9%, respectively.…”

Section: Eus-elastography -Strain Elastographymentioning

confidence: 99%

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Elastography for the pancreas: Current status and future perspective

Kawada¹,

Tanaka²

2016

WJG

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Elastography for the pancreas can be performed by either ultrasound or endoscopic ultrasound (EUS). There are two types of pancreatic elastographies based on different principles, which are strain elastography and shear wave elastography. The stiffness of tissue is estimated by measuring the grade of strain generated by external pressure in the former, whereas it is estimated by measuring propagation speed of shear wave, the transverse wave, generated by acoustic radiation impulse (ARFI) in the latter. Strain elastography is difficult to perform when the probe, the pancreas and the aorta are not located in line. Accordingly, a fine elastogram can be easily obtained in the pancreatic body but not in the pancreatic head and tail. In contrast, shear wave elastography can be easily performed in the entire pancreas because ARFI can be emitted to wherever desired. However, shear wave elastography cannot be performed by EUS to date. Recently, clinical guidelines for elastography specialized in the pancreas were published from Japanese Society of Medical Ultrasonics. The guidelines show us technical knacks of performing elastography for the pancreas. Core tip: Elastography for the pancreas had been considered to be difficult to perform with adequate accuracy and reproducibility because the pancreas is a small organ located deep in center of the human body. This review introduces the recent innovation of elastography for the pancreas, and makes recommendations on how to use various elastographic modalities for the pancreas. The review also shows us what we can know by performing elastography for the pancreas. Elastography may be a promising imaging modality for differential diagnosis between malignant and benign pancreatic tumors, for early diagnosis of chronic pancreatitis, and for identifying high-risk patients for pancreatic cancer. TOPIC HIGHLIGHTKawada N, Tanaka S. Elastography for the pancreas: Current status and future perspective.

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Section: Us-elastography -Shear Wave Elastograhymentioning

confidence: 99%

Section: Eus-elastography -Strain Elastographymentioning

confidence: 99%

Elastography for the pancreas: Current status and future perspective

Kawada¹,

Tanaka²

2016

WJG

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“…3,6,11,13,25 Iglesias-Garcia et al 26 demonstrated a 100% sensitivity and 93% specificity of quantitative EUS-E in 86 consecutive patients undergoing EUS evaluation for solid pancreatic masses for differentiating malignancies from benign pancreatic lesions. 13,26 This data was replicated by Opačić et al 27 in a prospective study involving 105 patients with pancreatic masses and 44 controls, with a sensitivity of 98% using the strain ratio. There are however, conflicting results from other studies leading to several high-quality meta-analyses.…”

Section: Eus With Elastographymentioning

confidence: 76%

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Luthra

Mishra

2017

Int J Gastrointest Interv

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“…A strain ratio of 4.65 and elasticity of 0.27% were the cut-off points for differentiation of pancreatic cancer from inflammatory masses [82]. Higher strain ratios were diagnostic for malignancy with an accuracy of 98% [83,84]. Three recent meta-analyses found sensitivity of 95-99%, specificity of 69-76%, and accuracy of 89-96% [85][86][87].…”

Section: Elastographymentioning

confidence: 99%

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

Seicean¹

2014

Pancreatic Cancer - Insights Into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment

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Quantitative Endoscopic Ultrasound Elastography: An Accurate Method for the Differentiation of Solid Pancreatic Masses

Cited by 275 publications

References 30 publications

Elastography for the pancreas: Current status and future perspective

Elastography for the pancreas: Current status and future perspective

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

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