Quantitative effects of inclusion of fat on muscle diffusion tensor MRI measurements

Williams, Sarah E.; Heemskerk, Anneriet M.; Welch, E. Brian; Li, Ke; Damon, Bruce M.; Park, Jane H.

doi:10.1002/jmri.24045

Cited by 75 publications

(108 citation statements)

References 19 publications

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“…Of interest, this exclusion had a different effect on the FA histogram: it deleted higher rather than lower FA values. This is in agreement with the report from Williams et al who showed that the low SNR voxels arising from fat had artifactual high FA values. The advantage of the histogram approach was that it did not require the direct identification of the nonmuscle tissue.…”

Section: Discussionsupporting

confidence: 93%

Age‐related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius

Sinha

Csapo

Malis

et al. 2014

Magnetic Resonance Imaging

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Purpose To investigate age related changes in diffusion tensor indices and fiber architecture of the medial and lateral gastrocnemius (MG and LG) muscles using diffusion tensor imaging (DTI). Materials and Methods The lower leg of five young and five senior subjects was scanned at 3T and DTI indices extracted using three methods: ROI, histogram and tract based. Tracked fibers were automatically edited to ensure physiologically relevant tracks. Pennation angles were measured with respect to the deep and superficial aponeuroses of both muscles. Results The three methods provided internally consistent measures of the DTI indices (correlation coefficient in the range of 0.90-0.99). The primary, secondary and tertiary eigenvalues in the MG and LG increased significantly in the senior cohort (p<0.05), while the small increase in fractional anisotropy (FA) with age was not significant (MG/LG: p=0.39/0.85; 95% CI:[ −0.059/-0.056, 0.116/0.064]). Fiber lengths of MG fibers originating distally were significantly decreased in seniors (p<0.05) while pennation angles decreased with age in the MG and LG but this was not significant. Conclusion Fiber atrophy and increased fibrosis have opposing effects on the diffusion indices resulting in a complicated dependence with aging. Fiber architectural changes could play a role in determining aging muscle function.

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Section: Discussionsupporting

confidence: 93%

Age‐related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius

Sinha

Csapo

Malis

et al. 2014

Magnetic Resonance Imaging

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“…This result is not surprising, considering that muscle ADC values in this study are calculated from a diffusion-weighted pulse sequence that encodes along a single diffusion direction, instead of the trace, for each b value. Since diffusion in muscle tissue is anisotropic [27–29], ADC values measured along only one direction, acquired by applying diffusion gradients simultaneously on all three axes, would be dependent on animal orientation in the scanner. Although the orientation was kept as consistent as possible, one might expect that slight differences between scans would have a greater impact on reproducibility in muscle tissue compared to most tumor models where water diffusion is nearly isotropic [16].…”

Section: Discussionmentioning

confidence: 99%

Assessing reproducibility of diffusion-weighted magnetic resonance imaging studies in a murine model of HER2+ breast cancer

Whisenant

Ayers

Loveless

et al. 2014

Magnetic Resonance Imaging

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Background and purpose The use of diffusion-weighted magnetic resonance imaging (DW-MRI) as a surrogate biomarker of response in preclinical studies is increasing. However, before a biomarker can be reliably employed to assess treatment response, the reproducibility of the technique must be established. There is a paucity of literature that quantifies the reproducibility of DW-MRI in preclinical studies; thus, the purpose of this study was to investigate DW-MRI reproducibility in a murine model of HER2+ breast cancer. Materials and methods Test–Retest DW-MRI scans separated by approximately six hours were acquired from eleven athymic female mice with HER2+ xenografts using a pulsed gradient spin echo diffusion-weighted sequence with three b values [150, 500, and 800 s/mm2]. Reproducibility was assessed for the mean apparent diffusion coefficient (ADC) from tumor and muscle tissue regions. Results The threshold to reflect a change in tumor physiology in a cohort of mice is defined by the 95% confidence interval (CI), which was ± 0.0972 × 10−3 mm2/s (±11.8%) for mean tumor ADC. The repeatability coefficient defines this threshold for an individual mouse, which was ± 0.273 × 10−3 mm2/s. The 95% CI and repeatability coefficient for mean ADC of muscle tissue were ± 0.0949 × 10−3 mm2/s (±8.30%) and ± 0.266 × 10−3 mm2/s, respectively. Conclusions Mean ADC of tumors is reproducible and appropriate for detecting treatment-induced changes on both an individual and mouse cohort basis.

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“…These are open questions which the current study cannot answer. Additional research employing other strategies, including diffusion tensor imaging (Sinha & Sinha, 2011; Sinha, Sinha, & Edgerton, 2006; Williams et al, 2013), is needed to further explore these provocative questions.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of muscle fat infiltration in children with spina bifida

Wren¹,

Ponrartana²,

Speybroeck³

et al. 2014

Research in Developmental Disabilities

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Children with spina bifida have well recognized functional deficits of muscle, but little is known about the associated changes in muscle anatomy and composition. This study used water-fat magnetic resonance imaging (MRI) to measure fat infiltration in the lower extremity muscles of 11 children with myelomeningocele, the most severe form of spina bifida. MRI measurements of muscle fat fraction (FF) were compared against manual muscle test (MMT) scores for muscle strength. The FF measurements were objective and reliable with mean inter-rater differences of <2% and intraclass correlation coefficients > 0.98. There was a significant inverse relationship between muscle FF and MMT scores (P ≤ 0.001). Surprisingly, however, muscles with negligible strength (MMT 0–1) exhibited a bimodal distribution of FF with one group having FF > 70% and another group having FF < 20%. The MRI also revealed striking heterogeneity amongst individual muscles in the same muscle group (e.g., 4% fat in one participant’s lateral gastrocnemius vs. 88% in her medial gastrocnemius), as well as significant asymmetry in FF in one participant with asymmetric strength and sensation. These results suggest that quantitative water-fat MRI may serve as a biomarker for muscle degeneration which may reveal subclinical changes useful for predicting functional potential and prognosis.

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Quantitative effects of inclusion of fat on muscle diffusion tensor MRI measurements

Cited by 75 publications

References 19 publications

Age‐related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius

Age‐related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius

Assessing reproducibility of diffusion-weighted magnetic resonance imaging studies in a murine model of HER2+ breast cancer

Heterogeneity of muscle fat infiltration in children with spina bifida

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