Quantitative EEG Effects and Plasma Concentration of Sodium Valproate: Acute and Long-Term Administration to Epileptic Patients

Sannita, Walter G.; Gervasio, L; Zagnoni, P.

doi:10.1159/000118622

Cited by 24 publications

(12 citation statements)

References 16 publications

(19 reference statements)

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“…The hypothesis of a functional derangement may be strength ened by the observation that, during administration of NaVPA, there is an amelioration of the EEG pattern in our population, primarily regarding the fast activity whose increase is positively correlated with drug plasma values. This latter observation seems to be in contrast with previous results [26] showing that during long-term administration of NaVPA to epileptic patients the EEG effects were not correlated with the drug plasma concen tration levels, while being concomitant with the reduction of specific epileptic EEG phenomena. In our population, the EEG effects after 2 months of NaVPA therapy were similar in patients who continued to present no EEG paroxysms as in those presenting a reduction or no change of these abnormalities.…”

Section: Discussioncontrasting

confidence: 99%

Sodium Valproate and Mental Processes in Newly Referred Epileptic Patients

Marciani

Maschio²,

Spanedda

et al. 1995

Neuropsychobiology

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Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta₁ and beta₂ relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities.

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Section: Discussioncontrasting

confidence: 99%

Sodium Valproate and Mental Processes in Newly Referred Epileptic Patients

Marciani

Maschio²,

Spanedda

et al. 1995

Neuropsychobiology

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“…Some studies have also been conducted on the qEEG effects of antiepileptic drugs16-18) and lithium,19,20) which are commonly used as mood stabilizers in psychiatric clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders

Hyun

Baik

Kang

2011

Clin Psychopharmacol Neurosci

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ObjectiveWe examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.MethodsThe drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.ResultsWe found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.ConclusionOur results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

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“…In a study by Shagass et al [37], only the reactivity of the EEG but not the eyes-closed resting EEG was influenced by antidepressants and antipsychotics. However, there are some compounds which can considerably alter the EEG, such as carbamazepine [38,39], lithium [40,41], valproic acid [42] and clozapine [43,44]. Patients treated with this medication displayed more activity over the anterior channels, but as there were no significant correlations in the band between actigraphic and electroencephalographic measures, we conclude that these substances have not substantially biased our results and do not account for the observed correlation.…”

Section: Discussionmentioning

confidence: 59%

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

et al. 2003

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Actigraphy is a quantitative method for the measurement of motor activity. In the present study, actigraphy was used to examine psychomotor correlates of brain activity. Thirty-four psychiatric patients (17 males and 17 females) with different diagnoses participated in this investigation. Directly after EEG recording, motor activity was measured with a wrist actimeter for 15 min in patients in the sitting position. The EEG was quantified by spectrum analysis, and the power spectra as well as other EEG-derived variables were correlated with actigraphic parameters. Occipital and temporoparietal β1 power was statistically significantly higher in patients with higher activity scores and lower in those with a high density of sleep (SB) or wake bouts (WB). A high density of SB or WB was also positively correlated with higher mean α power. Immobile phases measured by actigraphy were positively associated with occipital α and with frontal/frontopolar δ activity, preferentially on the side of the left hemisphere. Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal.

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Quantitative EEG Effects and Plasma Concentration of Sodium Valproate: Acute and Long-Term Administration to Epileptic Patients

Cited by 24 publications

References 16 publications

Sodium Valproate and Mental Processes in Newly Referred Epileptic Patients

Sodium Valproate and Mental Processes in Newly Referred Epileptic Patients

Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

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