Quantitative DWI implemented after DCE-MRI yields increased specificity for BI-RADS 3 and 4 breast lesions

Dijkstra, Hildebrand; Dorrius, Monique D.; Wielema, Mirjam; Pijnappel, Ruud M.; Oudkerk, Matthijs; Sijens, Paul E.

doi:10.1002/jmri.25331

Cited by 51 publications

(45 citation statements)

References 26 publications

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“…Diffusion‐weighted imaging (DWI), a common functional MRI technology, is widely used to describe the diffusion of water in living tissue by the apparent diffusion coefficient (ADC) . The ADC quantifies the monoexponential decay of signal intensity (SI), which reflects information related to the tumor microenvironment, such as cellularity, extracellular space, and the integrity of the cell membranes in a noninvasive manner . At present, DWI has been reported to be a strong adjunct to standard clinical MRI protocols …”

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confidence: 99%

Histogram analysis of diffusion kurtosis imaging based on whole‐volume images of breast lesions

Yuan

Kong

et al. 2019

Magnetic Resonance Imaging

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Background Breast diffusion kurtosis imaging (DKI) is a novel MRI technique to assess breast cancer but the effectivity still remains to be improved. Purpose To investigate the performance of whole‐volume histogram parameters derived from a DKI model for differentiating benign and malignant breast lesions. Study Type Retrospective. Population In all, 120 patients with breast lesions (62 malignant, 58 benign). Sequence DKI sequence with seven b‐values (0, 500, 1000, 1500, 2000, 2500, and 3000 s/mm2) and DWI sequence with two b‐values (0 and 1000 s/mm2) on 3.0T MRI. Assessment Histogram parameters of the DKI model (K and D) and the DWI model (ADC), including the minimum, maximum, mean, percentile values (25th, 50th, 75th, and 95th), standard deviation, kurtosis and skewness, were calculated by two radiologists for the whole lesion volume. Statistical Tests Student's t‐test was used to compare malignant and benign lesions. The diagnostic performances were evaluated by receiver operating characteristic (ROC) analysis. Results Kmax, Dmin, and ADCmin had the highest area under the curve (AUC) (0.875, 0.830, and 0.847, respectively), sensitivity (85.5%, 74.2%, and 77.4%, respectively), and accuracy (85.0%, 79.2%, and 81.7%, respectively) in their individual histogram parameter groups, and Kmax was found to outperform Dmin and ADCmin. ADC histogram parameters (from ADCmin to ADCsd) were significantly lower than D histogram parameters in all groups. Data Conclusion Kmax, Dmin, and ADCmin were found to be better metrics than the corresponding average values for differentiating benign from malignant tumors. Histogram parameters derived from the DKI model provided more information and had better diagnostic performance than ADC parameters derived from the DWI model. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:627–634.

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confidence: 99%

Histogram analysis of diffusion kurtosis imaging based on whole‐volume images of breast lesions

Yuan

Kong

et al. 2019

Magnetic Resonance Imaging

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“…IVIM-DWI technology has been applied in the diagnosis of many diseases, e.g. carcinomas, lesions or infections, but so far its application in hypothalamic feeding studies was only rarely reported [30,31,32]. This might be due to the tiny volume of hypothalamus the low magnetic field of which might be easily distorted.…”

Section: Discussionmentioning

confidence: 94%

The Effect of Feeding Behavior on Hypothalamus in Obese Type 2 Diabetic Rats with Glucagon-like Peptide-1 Receptor Agonist Intervention

Lu¹,

Chen²,

Yan³

et al. 2018

Obes Facts

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Objective: To investigate the utility of intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) derived parameters in hypothalamus for monitoring the effect of Exendin-4 (Ex-4) intervention on the feeding behavior in obese diabetic rats within early feeding. Methods: 21 obese and 19 non-obese rats which were treated with streptozotocin injections were initially divided into an obese diabetes group (OD, n = 10), a non-obese diabetes group (D, n = 8), an obese group (O, n = 9) and a non-obese group (N, n = 9). Then, the rats in the 4 groups received subcutaneous injections of Ex-4, and feeding behavior was examined at 5, 35, 65, 95, and 125 min. The hypothalamic function was evaluated by IVIM-DWI. Finally, the relationship between the hypothalamic function and the amount of food intake was analyzed. Results: In comparison with the N group, the food intake significantly decreased in the O , OD, and D groups in response to Ex-4. Furthermore, a significant positive correlation was found between food intake and D values at different times from 5 to 125 min after Ex-4 intervention in all 4 groups. Conclusion: A direct correlation between the change of hypothalamic function and feeding behavior was detected in OD rats with Ex-4 intervention in the early feeding period. The hypothalamic D value derived from IVIM-DWI is promising to reflect the dynamic change of hypothalamic function due to intervention.

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“…Recently, other functional MRI parameters such as DWI have been implemented in clinical routine, as several studies have demonstrated that DWI with ADC mapping improves diagnostic accuracy in breast cancer . In addition, DWI with ADC mapping has been assessed for correlations of ADC values and molecular breast cancer subtypes .…”

Section: Breastmentioning

confidence: 99%

“…109 Recently, other functional MRI parameters such as DWI have been implemented in clinical routine, as several studies have demonstrated that DWI with ADC mapping improves diagnostic accuracy in breast cancer. [111][112][113][114][115] In addition, DWI with ADC mapping has been assessed for correlations of ADC values and molecular breast cancer subtypes. [116][117][118] All studies independently discovered that HER2-positive cancers had the highest ADC values, whereas luminal B cancers without HER2 overexpression had the lowest ADC values.…”

Section: Molecular Breast Cancer Subtypesmentioning

confidence: 99%

Background, current role, and potential applications of radiogenomics

Pinker

Shitano

Sala

et al. 2017

Magnetic Resonance Imaging

143

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Quantitative DWI implemented after DCE-MRI yields increased specificity for BI-RADS 3 and 4 breast lesions

Cited by 51 publications

References 26 publications

Histogram analysis of diffusion kurtosis imaging based on whole‐volume images of breast lesions

Histogram analysis of diffusion kurtosis imaging based on whole‐volume images of breast lesions

The Effect of Feeding Behavior on Hypothalamus in Obese Type 2 Diabetic Rats with Glucagon-like Peptide-1 Receptor Agonist Intervention

Background, current role, and potential applications of radiogenomics

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