Quantitative dual-energy radiographic absorptiometry of the lumbar spine: in vivo comparison with dual-photon absorptiometry.

Borders, Jack C.; Kerr, Eubulus J.; Sartoris, D J; Stein, J. A.; Ramos, E; Moscona, Avraham; Resnick, D

doi:10.1148/radiology.170.1.2909085

Cited by 51 publications

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“…Our study is the first one assessing the precision of DEXA of the proximal femur by repeated measurements both in young and in elderly women. The results confirm the higher precision obtained with X-ray absorptiometry, 1% for the femoral neck in the elderly, a number which is similar to the precision of the lumbar spine measurement [13][14][15]. The lower precision of the Ward's triangle region might be due to the fact that the bone mineral content of this limited area is very small.…”

Section: Fractured Patientssupporting

confidence: 81%

Bone mineral density of the hip measured with dual-energy X-ray absorptiometry in normal elderly women and in patients with hip fracture

et al. 1991

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Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DEXA) in 133 normal females on five regions of the femoral site: neck, trochanteric, intertrochanteric, Ward's triangle, and total area of the proximal femur. One hundred and twenty-five women (56 older than 65, range 65-97, and 69 with an age range of 21-65) were also examined for spinal bone mineral density. The mean in vivo precision (CV%) of the measurements with repositioning assessed on five young and eight elderly patients was ranged from 0.7% to 1.7% but lower for Ward's triangle (CV = 2.95% and 3.87%). Between 30 and 90 years, a linear age-related bone mineral decrease was found at all sites with a similar magnitude of bone loss for the femoral neck, total or intertrochanteric regions (-33% to -39%). A greater decrease was found for the Ward's triangle region (-61%). In the subgroup of elderly women (65-97 years old), the lumbar BMD measured with an anteroposterior incidence did not decrease significantly with age, contrasting with an average 27% decrease of the BMD of the hip between 65 and 90 years of age. In addition, 31 patients suffering either from a cervical (n = 12) or pertrochanteric (n = 19) fracture were measured on their contralateral femur 15 to 30 days after the fracture event. The mean calculated BMD values were, depending on the measured area, from 14% to 21% lower than those reported for age-matched controls (z-score from -1.11 to -0.65). A fracture threshold was determined for each site from this population and the elderly controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Fractured Patientssupporting

confidence: 81%

Bone mineral density of the hip measured with dual-energy X-ray absorptiometry in normal elderly women and in patients with hip fracture

et al. 1991

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“…Other authors [7,8] also found lower BMD in men who had undergone partial gastrectomy (85%) and total gastrectomy (86%) than in the control population. Recently, DXA was introduced for the quantitative analysis of metabolic bone disease [11,12]. Inoue et al [14] demonstrated that BMD in gastrectomized patients (0.85 g/cm 2 ) is significantly lower than that in healthy men (0.96 g/cm 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Since DXA has high resolution and great speed, and permits accurate and reproducible measurements [11,12], this noninvasive method clinically serves as a useful technique for identifying and treating osteoporosis [13,14].…”

mentioning

confidence: 99%

Osteoporosis After Gastrectomy: Bone Mineral Density of Lumbar Spine Assessed by Dual-Energy X-ray Absorptiometry

Adachi

Shiota

Murakami

et al. 2000

Calcified Tissue International

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Although osteoporosis is a common clinical disorder associated with gastric surgery, long-term effects of gastrectomy on bone metabolism are still unclear. The purpose of this study was to clarify the incidence and risk factors of osteoporosis after gastrectomy using univariate and multivariate analyses of quantitative measurements. The study included 59 patients who had undergone gastrectomy more than 5 years before. There were 38 men and 21 women, aged 37-81 years, mean 64 years. Bone mineral density (BMD) of L2-L4 spine was measured using dual-energy X-ray absorptiometry (DXA). Absolute value of BMD (g/cm2) and age- and sex-matched BMD (%) were given. The mean BMD was 0.766 g/cm2, and the incidence of osteoporosis (BMD less than 0.70 g/cm2) was 37%: 18% in men and 71% in women. The mean age- and sex-matched BMD was 85.9%: 87.5% in men and 83.1% in women. Univariate and multivariate analyses revealed that BMD was significantly associated with the age and sex of patients, but was not influenced by the type of gastrectomy (partial versus total) and years after operation (< 20 versus 20 <). Our study clarified the fact that postgastrectomy osteoporosis was frequent in the aged or female patients. BMD should be evaluated after gastrectomy, especially in the aged and in women.

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“…Other investigations to determine the accuracy of DXA have compared this technology with either dual photon absorptiometry or hydroxyapatite phantoms of known density [8,9,12,13]. Although these methods appear reasonable to assess the ability of DXA to determine mineral content, they do not provide information concerning DXA's ability to distinguish between the variations in cortical and cancellous bone that occur with age.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have attempted to describe the accuracy of DXA in terms of a correlation with dual photon absorptiometry, a technology that is highly correlated with ash weight [11]. These studies have found significant positive relationships, with Pearson coefficients above 0.9 when DXA BMD and dual photon absorptiometry BMD measurements from the same bone were correlated [9,12,13]. The ability of DXA to measure BMD accurately has been questioned in the literature, as it does not provide a true volumetric bone density (g/cm 3 ) but rather an areal density (g/cm 2 ).…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Cortical and Cancellous Bone to Dual-Energy X-ray Absorptiometry Measurements in the Female Proximal Femur

Lundeen

Knecht

Vajda

et al. 2001

Osteoporosis International

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Dual-energy X-ray absorptiometry (DXA) is the most common method for determining bone mineral density (BMD) in the proximal femur. However, there remain questions concerning the contribution of cortical and cancellous bone to this technology in the proximal femur. The purpose of this investigation was to identify structural and compositional characteristics of human bone in the proximal femur that significantly influence DXA BMD measurements. Twenty-four femora were obtained at autopsy from Caucasian females ranging in age from 17 to 92 years (mean +/- SD, 61 +/- 25 years). DXA scans were performed on each specimen with a Hologic QDR-2000 densitometer. Direct measurements were determined from proximal femoral sections for cancellous bone (volume fraction, ash fraction, cancellous cross-sectional area and percent cancellous cross-sectional area), cortical bone (thickness, ash fraction, porosity, cortical cross-sectional area and percent cortical cross-sectional area) and anteroposterior thickness. These parameters were compared with the associated DXA measurements by means of simple and multiple regressions. Cancellous volume fraction was the best predictor of variability of DXA measurements for both the neck and trochanter, with an R2 of 0.87 and 0.76, respectively (p < 0.0001). There was only a minor influence of cortical factors such as thickness (neck and trochanter R2 = 0.51 and 0.42, respectively, p < 0.001) and trochanteric cross-sectional area (R2 = 0.21, p < 0.05). Although the accuracy for determining specific components of the proximal femur was low, the DXA BMD measurement was a strong predictor of cancellous bone factors, but not cortical bone factors that have been shown to change significantly with age.

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Quantitative dual-energy radiographic absorptiometry of the lumbar spine: in vivo comparison with dual-photon absorptiometry.

Cited by 51 publications

References 0 publications

Bone mineral density of the hip measured with dual-energy X-ray absorptiometry in normal elderly women and in patients with hip fracture

Bone mineral density of the hip measured with dual-energy X-ray absorptiometry in normal elderly women and in patients with hip fracture

Osteoporosis After Gastrectomy: Bone Mineral Density of Lumbar Spine Assessed by Dual-Energy X-ray Absorptiometry

The Contribution of Cortical and Cancellous Bone to Dual-Energy X-ray Absorptiometry Measurements in the Female Proximal Femur

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