Quantitative diffusion-weighted magnetic resonance imaging of normal and diseased uterine zones

Kılıçkesmez, Özgür; Bayramoğlu, Sibel; İnci, Ercan; Cimilli, Tan; Kayhan, Arda

doi:10.1080/02841850902735858

Cited by 76 publications

(60 citation statements)

References 16 publications

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“…Like the other reports, the present study also demonstrated a significant zonal difference of ADC values and with some of the FA values (4,5,15,19,20).…”

Section: Discussionsupporting

confidence: 72%

“…However, the thickness and signal intensities of the myometrium and especially the endometrium change during different phases of the menstrual cycle (2,3). Depending on the histologic changes in the myometrium and endometrium, variation of the apparent diffusion coefficient (ADC) values of the normal uterine zones in the different periods of the cycle is demonstrated in the literature (4,5). Diffusion-weighted imaging (DWI) can show abnormal signals reflecting pathologic foci based on differences in molecular diffusion.…”

mentioning

confidence: 99%

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Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Kılıçkesmez¹,

Fırat

Oygen

et al. 2016

Balkan Med J

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Background: Diffusion and diffusion tensor imaging techniques (DTI) are widely available and used both in central nervous system and body imaging, including gynecological diseases. Aims: The aims of this study were to assess the capability of DTI of uterine zones in relation to the menstrual cycle and ascertain the normal apparent diffusion coefficient and fractional anisotropy values at 3T magnetic resonance imaging (MRI).

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“…Like the other reports, the present study also demonstrated a significant zonal difference of ADC values and with some of the FA values (4,5,15,19,20).…”

Section: Discussionsupporting

confidence: 72%

mentioning

confidence: 99%

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Kılıçkesmez¹,

Fırat

Oygen

et al. 2016

Balkan Med J

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“…The mean ADC value of cervical cancer lesions is lower than that of normal cervical tissue (112,(118)(119)(120)(121)(122)(123)(124)(125)(126) (123,(125)(126)(127). A prospective study of 61 patients with cervical cancer showed that all lymph nodes with a short-axis diameter larger than 5 mm were detected by DWI, regardless of whether they were benign or metastatic.…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

“…DWI imaging of endometrial tumors has decreased ADC values (108)(109)(110)(111)(112)(113)(114)(115)(116). Endometrial carcinoma is clearly depicted as an area of increased signal intensity relative to the surrounding hypointense myometrium on DWI (116).…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

“…Endometrial carcinoma is clearly depicted as an area of increased signal intensity relative to the surrounding hypointense myometrium on DWI (116). ADC measurements have the potential to quantitatively differentiate Stage IA endometrial carcinoma from normal endometrium, endometrial dysplasia and benign diseases of the endometrium, such as endometrial hyperplasia, adenomyosis, submucosal leiomyoma, and endometrial polyps (108)(109)(110)(111)(112)(113)(114)(115)(116). DWI and combined DWI/T2W MRI can increase the overall detection sensitivity for endometrial carcinoma (113).…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

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Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

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Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

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Ephrin reverse signaling controls palate fusion via a PI3 kinase‐dependent mechanism

Miguel

Serrano

Sachar

et al. 2011

Developmental Dynamics

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Secondary palate fusion requires adhesion and epithelial-to-mesenchymal transition (EMT) of the epithelial layers on opposing palatal shelves. This EMT requires transforming growth factor b3 (TGFb3), and its failure results in cleft palate. Ephrins, and their receptors, the Ephs, are responsible for migration, adhesion, and midline closure events throughout development. Ephrins can also act as signal-transducing receptors in these processes, with the Ephs serving as ligands (termed ''reverse'' signaling). We found that activation of ephrin reverse signaling in chicken palates induced fusion in the absence of TGFb3, and that PI3K inhibition abrogated this effect. Further, blockage of reverse signaling inhibited TGFb3-induced fusion in the chicken and natural fusion in the mouse. Thus, ephrin reverse signaling is necessary and sufficient to induce palate fusion independent of TGFb3. These data describe both a novel role for ephrins in palate morphogenesis, and a previously unknown mechanism of ephrin signaling. Developmental Dynamics 240:357-364,

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Quantitative diffusion-weighted magnetic resonance imaging of normal and diseased uterine zones

Abstract: The present study shows that ADC measurements have the potential to quantitatively differentiate between normal and cancerous tissues of the uterine zones. We propose adding DWI as an adjunct sequence in the MR protocol for the assessment of uterine lesions.

Cited by 76 publications

References 16 publications

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Diffusion Tensor Imaging of the Uterine Zones Related to the Menstrual Cycle and Menopausal Status at 3 Tesla MRI

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Ephrin reverse signaling controls palate fusion via a PI3 kinase‐dependent mechanism

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