Quantitative diffusion tensor tractography of the motor and sensory tract in children with cerebral palsy

Yoshida, Shoko; Hayakawa, Katsumi; Yamamoto, Akira; Okano, Souzo; Kanda, Toyoko; Yamori, Yuriko; Yoshida, Naoko; Hirota, Haruyo

doi:10.1111/j.1469-8749.2010.03669.x

Cited by 101 publications

(144 citation statements)

References 23 publications

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“…Lessening illness severity in the first hours of life, by means such as temperature regulation and ventilation strategies, might offer potential to improve motor pathway development in premature newborns. As previous research has shown that altered development of the corticospinal tract in childhood has been associated with poor motor outcomes [51,52], longitudinal follow-up of this cohort will determine if corticospinal tract development in the neonatal period is related to motor outcomes of premature newborns.…”

Section: Resultsmentioning

confidence: 97%

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Zwicker¹,

Grunau²,

Adams³

et al. 2013

Pediatric Neurology

115

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Premature infants are at risk for adverse motor outcomes, including cerebral palsy and developmental coordination disorder. The purpose of this study was to examine the relationship of ante-, peri-, and postnatal risk factors for abnormal development of the corticospinal tract, the major voluntary motor pathway, during the neonatal period. In a prospective cohort study, 126 premature neonates (24-32 weeks gestational age) underwent serial brain imaging near birth and at term-equivalent age. Using diffusion tensor tractography, mean diffusivity and fractional anisotropy of the corticospinal tract were measured to reflect microstructural development. Generalized estimating equation models examined associations of risk factors on corticospinal tract development.The perinatal risk factor of greater early illness severity [as measured by the Score for Neonatal Acute Physiology-II (SNAP-II)] was associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.02), even after correcting for gestational age at birth and postnatal risk factors (p=0.009). Consistent with previous findings, neonatal pain adjusted for morphine and postnatal infection were also associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.03 and 0.02 respectively). Lessening illness severity in the first hours of life might offer potential to improve motor pathway development in premature newborns.

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Section: Resultsmentioning

confidence: 97%

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Zwicker¹,

Grunau²,

Adams³

et al. 2013

Pediatric Neurology

115

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“…DTI carries unique anatomical information that cannot be obtained by relaxation-based contrasts and prior studies have demonstrated the usefulness of evaluating the correlation between white matter damage and clinical function in preterm infants and spastic CP patients (11)(12)(13)(14)(15)(16)(17). Previously, manual-ROI based analyses of DTI data, including ours, have been reported for CP patients (11)(12)(13)(14)(15)(16)(17), which have indicated more diffuse and severe involvement of the deep gray matter and white matter structures in athetotic CP patients compared to the spastic type. These analyses, however, measured only a small portion of the brains, leaving many brain structures unmeasured.…”

Section: Introductionmentioning

confidence: 99%

Anatomical characterization of athetotic and spastic cerebral palsy using an atlas‐based analysis

Yoshida

Faria

Oishi

et al. 2013

Magnetic Resonance Imaging

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Purpose-To analyze diffusion tensor imaging (DTI) in two types of cerebral palsy (CP): the athetotic-type and the spastic-type, using an atlas-based anatomical analysis of the entire brain, and to investigate whether these images have unique anatomical characteristics that can support functional diagnoses.Methods-We retrospectively analyzed the DTI of seven children with athetotic-type, 11 children with spastic-type, and 20 healthy control children, all age-matched. The severity of motor dysfunction was evaluated with the Gross Motor Function Classification System (GMFCS). The images were normalized using a linear transformation, followed by large deformation diffeomorphic metric mapping. For 205 parcellated brain areas, the volume, fractional anisotropy, and mean diffusivity were measured. Principal component analysis (PCA) was performed for the Z scores of these parameters.Result-The GMFCS scores in athetotic-type were significantly higher than those in spastic-type (p<0.001). PCA extracted anatomical components that comprised the two types of CP, as well as the severity of motor dysfunction. In the athetotic group, the abnormalities were more severe than in the spastic group. In the spastic group, significant changes were concentrated in the lateral ventricle and periventricular structures.Conclusion-Our results quantitatively delineated anatomical characteristics that reflected the functional findings in two types of CP.

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“…5,9 Moreover, the overall severity of CP, measured by, for example, the Gross Motor Function Classification System, 10 appears to correlate with diffusion parameters in motor 9,[11][12][13] and/or sensory pathways. [14][15][16] In addition, correlations have been shown between diffusion measures in motor and sensory tracts and specific measures of sensory and/or motor functions. [5][6][7][17][18][19][20] Some studies suggest that sensory and motor functions correlate more strongly with changes in the sensory pathways (superior and posterior thalamic radiation) than changes in the motor pathways (CST).…”

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confidence: 99%

Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy

Lennartsson

Holmström

Eliasson

et al. 2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.

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Quantitative diffusion tensor tractography of the motor and sensory tract in children with cerebral palsy

Cited by 101 publications

References 23 publications

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Anatomical characterization of athetotic and spastic cerebral palsy using an atlas‐based analysis

Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy

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