Quantitative determination of urinary delta-aminolevulinic acid as an index of lead exposure by high-performance liquid chromatography.

Ogata, Masana; Taguchi, Toyohiro

doi:10.2486/indhealth.24.259

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The specificity is good enough to use this method for screening for lead exposure. 8 The ALA pyrrole complex is formed with ethyl acetoacetate, which forms chromophore with Ehrlich reagent and extracted with chloroform. 9 Increased urinary δ-ALA levels found in exposed subjects in the present study might be the impact of lowlevel long-term exposure of gasoline, petrol and petroleum products reinforces the notion that δ-ALA can serve as a surrogate marker for lead exposure.…”

Section: Discussionmentioning

confidence: 99%

Estimation of urinary delta aminolevulinic acid levels in gasoline and petrol pump workers as an index of lead exposure

Patharkar¹,

Patil²,

Thorat³

et al. 2022

IJCBR

View full text Add to dashboard Cite

Lead poisoning is a phenomenon which with growing globalization is being a subject of worry.ALA i.e Amino levulinic acid is a precursor of hemoglobin, which is synthesized in mitochondria by two main components succinyl Co-A and glycine in presence of ALA-S i.e. amino levulinic acid-synthase. Urinary ALA (ALA-U) has been a recommended biomarker for lead exposure. Inhibition of Amino levulinic acid-dehydratase (ALA-D) results into activation of ALA-S which further synthesizes ALA, excess of ALA is accumulated in the blood, plasma, urine. Present manuscript is focused on the estimation of levels of ALA in the urine of gasoline and pertol pump workers, by acidifying the urine to extract out ALA and reading it colorimetrically as they are exposed to fumes released by gasoline, petrol, and petroleum products which contains lead. Awareness and safety measures such as protective masks and gears should be provided by the respective organisations to the workers.

show abstract

Section: Discussionmentioning

confidence: 99%