Quantitative Determination of Multiple Elements in Botanicals and Dietary Supplements Using ICP-MS

Abstract

A method was developed and validated for the analysis of 21 elements in various botanicals and dietary supplements using ICP-MS. Closed-vessel microwave digestion of botanicals and dietary products was assisted by various different procedures. The samples digested with concentrated nitric and hydrochloric acid (8:2) revealed the best recoveries (91-106%) using the reference certified materials (SRM 3280, SRM 1566b). The method was validated for linearity, precision, accuracy, LOD, and LOQ. The LOD was found to be in the range from 0.005 to 1.09 ng/mL with the exception of potassium. Eleven botanicals and 21 dietary supplements were analyzed. Among the analyzed elements, K was the most abundant followed by Na, Mg, Al, Ca, Mn, and Fe, whereas V, Cr, Co, Ni, Se, Cd, Hg, and Pb were present in low concentrations in most of the samples. The results showed that the ICP-MS method is a simple, fast, and reliable for the multielement determination in dietary supplements and botanicals.

Inorganic elemental compositions of commercial multivitamin/mineral dietary supplements: Application of collision/reaction cell inductively coupled-mass spectroscopy

“…Octopole ICP-MS has been used for separation of analyte signals from known spectral interferences. Sample digestion using a microwave procedure and analysis were based on a method developed for multi-element analysis of botanicals using ICP-MS (Avula et al, 2010). A total of 24 elements have been determined in 35 of the most commonly used MVM dietary supplements, either in capsule, tablet, liquid or powder form, in the USA.…”

“…The digestion of samples was conducted as described by Avula, Wang, Smillie, Duzgoren-Aydin, and Khan (2010). The digestion programme consisted of a brief ramp time of 5 min to reach 180°C and a digestion was performed for 15 min at a power of 1600 W. The vessels were cooled and opened.…”

Prediction of the edaphic factors influence upon the copper and cobalt accumulation in two metallophytes using copper and cobalt speciation in soils

“…To determine CuCo concentration in shoot of A. chinensis two steps were performed. A mass of shoot were digested using a mixture of 8 mL HNO 3 and 2 mL HCl (Avula et al 2010) with a low pressure mineralization (Lavilla et al 1999). Vessels containing the mix were placed in a Mars 5 microwave (Microwave Accelerated Reaction System -CEM corporation, USA) according to the Avula et al (2010) treatment.…”

“…A mass of shoot were digested using a mixture of 8 mL HNO 3 and 2 mL HCl (Avula et al 2010) with a low pressure mineralization (Lavilla et al 1999). Vessels containing the mix were placed in a Mars 5 microwave (Microwave Accelerated Reaction System -CEM corporation, USA) according to the Avula et al (2010) treatment. Then, Cu and Co concentrations in samples were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) (Thermo Scientific XSERIES2).…”

Application of treated wastewater on yield and heavy metals content of seeds in sunflower cultivars

“…Heavy metals analysis was carried out after mineralization using acids for seed samples. Heavy metal contents (Fe, Zn, Cu, Mn, As, Cd and Pb) were measured by the inductively coupled plasma mass spectrometry (ICP_MS) technique (Avula et al, 2010).…”