Quantitative determination of melatonin in milk by LC-MS/MS

D.Karunanithi,; Radhakrishna, A.; Sivaraman, Kunnummal Parambil; Biju, V.M.

doi:10.1007/s13197-013-1221-6

Cited by 39 publications

(16 citation statements)

References 27 publications

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“…There is limited research regarding MEL in animal foods [40]; however, Tan et al [31] reported that MEL is found in animal products and in cow’s milk at 0.014 ng/g [31,41,42], human breast milk, containing up to 0.042 ng/g [31,43] and in the colostrum [31]. Interestingly, the concentration of MEL was found to be higher in fish sources (specifically salmon at 3.7 ng/g) and eggs (6.1 ng/g), compared to other animal products including beef (2.2 ng/g), lamb (1.6 ng/g), pork (2.5 ng/g) and milk [31].…”

Section: Sources Of Melmentioning

confidence: 99%

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Bojková

Kubatka

Qaradakhi

et al. 2018

IJMS

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Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research.

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Section: Sources Of Melmentioning

confidence: 99%

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Bojková

Kubatka

Qaradakhi

et al. 2018

IJMS

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“…It interact with various free radicals in vitro and in vivo, stimulates the activity of several antioxidative enzymes (catalase, copper/zinc superoxide dismutase, glutathione peroxidase), down-regulates pro-oxidative enzymes (myloperoxidase, nitric oxide synthase) (Reiter et al, 2009), and has demonstrated a positive effect in a multitude of neonatal diseases (Gitto et al, 2013). Melatonin has been quantified in human milk by several researchers (Kimata, 2007;Honorio-França et al, 2013;Karunanithi et al, 2014) and has proven as to have a positive effect in the neonate´s wellbeing (Engler et al, 2012).…”

Section: Melatoninmentioning

confidence: 99%

Breastfeeding: Antioxidative properties of breast milk

Matos¹,

Ribeiro

Guerra

2015

JAB

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Birth is an event that exposes the newborn baby to a high concentration of free radicals (reactive oxygen species (ROS) / reactive nitrogen species (RNS)), which can contribute to several diseases. The balanced equilibrium between ROS / RNS and the antioxidant system of the newborn is a key factor in preventing a plethora of diseases. The antioxidant system involves endogenous and exogenous molecules, from vitamins (A, E, C), to enzymes (glutathione peroxidase, superoxide dismutase), metals (copper (Cu), zinc (Zn), and selenium (Se)) and other molecules (coenzyme Q 10 , melatonin) that can act in a synergistic manner to deactivate free radicals. A competent antioxidant system of the baby is strongly dependent on the intake of free radical deactivating molecules from feeding, either maternal or formula milk, with several studies pointing that breast milk has more powerful antioxidant effects on lowering the infant´s oxidative status. An improved understanding of the antioxidant molecules, their mechanism of action, and the relationships between them, are key factors to comprehend all the potential benefits of human breastfeeding in this matter. The purpose of this review is to describe different research efforts and methodologies of evaluation of total antioxidant system (TAS) in human milk, and to evaluate and summarize the contribution of different antioxidant molecules in TAS, with special emphasis in the last 10 years.

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“…Since then, it has been found in more than 140 different plant species and foods [5][6][7][8][9][10][11][12][13]. Furthermore, healthy subjects synthesize melatonin not only in the pineal gland [14], but also in a wide range of other organs.…”

Section: Introductionmentioning

confidence: 99%

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

et al. 2015

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Single-walled carbon nanotubes (SWCNT), multiwalled carbon nanotubes (MWCNT) and graphene have been tested as carbon allotropes for the modification of carbon screen-printed electrodes (CSPEs) to simultaneously determine melatonin (MT) and serotonin (5-HT). Two groups of CSPEs, both 4 mm in diameter, were explored: The first includes commercial SWCNT, MWCNT and graphene, the second includes SWCNT, MWCNT, graphene oxide nanoribbons and reduced nanoribbons that were drop casted on the electrodes. The carbon nanomaterials enhanced the electroactive area in the following order: CSPE

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Quantitative determination of melatonin in milk by LC-MS/MS

Cited by 39 publications

References 27 publications

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Breastfeeding: Antioxidative properties of breast milk

Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin

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