Quantitative determination of lansoprozole in capsules and spiked human urine by spectrophotometry through ion-pair complex formation reaction

Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

“…The suggested method was also applied for the quantification of the studied drugs in actual wastewater samples obtained from different pharmaceutical industrial factories around the KSA. To validate the results obtained by the cited method, the found concentrations in the actual wastewater samples were compared with those obtained by applying the reference methods for the determination of the studied PPIs in the same samples [ 10 , 18 , 26 ], declaring good matching between the results ( Table 4 ). The standard addition technique was well applied for the actual wastewater samples, confirming the excellent performance of the cited method ( Table 5 ).…”

“…Calibration plots were used to get the unknown concentrations. The obtained results were compared to those obtained by applying reference methods for the determination of OMP, PNT, and LNZ [ 10 , 18 , 26 ] after sample pretreatment by the same extraction protocol. Additionally, the suggested method was validated by the application of the standard addition procedure to the actual wastewater samples at three concentration levels (10, 20, and 30 ng/mL).…”

“…LNZ (C 16 H 13 F 3 N 3 NaO 2 S), sodium;2-[[3-methyl-4-(2,2,2-trifluoromethoxy)pyridin-2-yl]methylsulfinyl]benzimidazol-1-ide, is a potent PPI. It was determined spectrophotometrically in capsules and spiked human urine through ion-pair complex formation with bromocresol purple and bromothymol blue [ 18 ]. Kinetic spectrophotometry was applied for the quantification of LNZ in a pharmaceutical formulation via its reaction with alkaline potassium permanganate at room temperature [ 19 ].…”

Box-Behnken Assisted Validation and Optimization of an RP-HPLC Method for Simultaneous Determination of Domperidone and Lansoprazole

“…On the basis of analyzing the above parameters, the best quality attributes are selected for the optimization purpose. However, the method developed by Janardhanan et al in 2011 [21] and by Patel et al in 2009 [22] is different from this method in terms of mobile phase, calibration range as well as Quality by Design (QbD)-based optimization and validation of the method. HPLC separation techniques based on the "trial and error" methodology are time-consuming and can only provide information on the responsiveness of various critical analytical parameters.…”

Use of picric acid and iodine as electron acceptors for spectrophotometric determination of lansoprazole through a charge-transfer complexation reaction

“…A number of colour formation reactions utilizing different reagents have been employed for the visible spectrophotometric determination of LAN in pharmaceuticals [4,12,40,[44][45][46][47][48][49][50][51][52][53][54][55][56]. The reported methods are based on complexation and oxidative coupling [44], formation of a charge-transfer complex [4,45], redox followed by complexation or colour bleaching [46][47][48][49], bromination [50], ion-pair complexation reaction [51][52][53][54][55] and coupling with diazotized p-nitroaniline [56]. However, most of the reported visible spectrophotometric methods suffer from one or more disadvantages, such as poor sensitivity [4,44,45], a narrow range of determination [47][48][49][50], use of a heating step [44,48], and use of an extraction step [52][53][54][55], as shown in Table 1.…”