Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Wu, Yao‐Kuang; Chen, Kuei-Tien; Kuo, Yung-Bin; Huang, Ya-Shu; Chan, Err–Cheng

doi:10.1016/j.canlet.2008.08.023

Cited by 27 publications

(25 citation statements)

References 26 publications

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“…Chyczewska et al [27] and Falleni et al [28] reported that survivin expression in tumor tissues is not correlated with an unfavorable prognosis in NSCLC. In contrast to these studies, Wu et al [17] reported that a quantitative assay of survivin levels in pleural effusion could be useful for lung cancer prognosis. In agreement with this study, we demonstrated that positive survivin expression is significantly correlated with shorter overall survival, and that survivin was the only independent prognostic factor significantly associated with overall survival in a multivariate Cox regression analysis.…”

Section: Discussionmentioning

confidence: 95%

“…Survivin is currently attracting considerable interest both as a potential cancer biomarker [15] and as a new target for cancer treatment [16]. Wu et al [17] reported that lung cancer patients with low survivin expression in pleural effusions had higher survival rates. Currently, there is no consensus with regard to which tumor markers are the most effective in detecting MPE.…”

Section: Introductionmentioning

confidence: 98%

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Elevated survivin is associated with a poor response to chemotherapy and reduced survival in lung cancer with malignant pleural effusions

Park

Hwang

Shim

et al. 2011

Clin Exp Metastasis

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Survivin has been shown to inhibit apoptosis, enhance proliferation and promote angiogenesis. This study aimed to identify diagnostic value of survivin protein in malignant pleural effusion (MPE) and to investigate the prediction of response to chemotherapy and the prognostic role on pleural survivin in lung cancer patients with MPE. Pleural effusion samples were collected from 67 patients with MPE (58 lung cancers; 9 extrathoracic tumors), and from 68 patients with benign conditions (31 with pneumonia; 37 with tuberculosis). Concentrations of pleural fluid survivin, Cyfra 21-1, and carcinoembryonic antigen (CEA) were measured by enzyme-linked immunosorbent assay. The expression profile of survivin in pleural fluid, and its association with survival, were investigated. Survivin levels were significantly elevated in patients with MPE, especially primary lung cancer than in those of benign origin. Survivin, Cyfra 21-1, and CEA varied in diagnostic accuracy for differentiating MPE from benign pleural effusion by 67.5, 68.3, and 93.4%, respectively. Lung cancer patients with MPE who were positive for survivin expression were more refractory to chemotherapy (P = 0.003). Positive for survivin expression was correlated with a reduced overall survival in univariate (P = 0.0001) and multivariate (P = 0.004) analyses. Using the appropriate cut-off points, CEA in pleural fluid has a higher accuracy than other tumor markers, and that survivin has a low diagnostic accuracy for differentiating MPE from benign pleural effusion. Our findings suggest that positive survivin expression may be used as a predictor of a poor response to chemotherapy and shorter survival in lung cancer patients with MPE.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Elevated survivin is associated with a poor response to chemotherapy and reduced survival in lung cancer with malignant pleural effusions

Park

Hwang

Shim

et al. 2011

Clin Exp Metastasis

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“…A study on ovarian cancer also found that survivin overexpression in tumors is associated with adverse outcomes [15,16]. Recently, studies have suggested that testing of extracellular survivin in urine and pleural effusion is an effective diagnostic tool for the early detection of cancer [8,9]. Thus, it appears that the serum level of survivin might be useful in both the diagnosis and prognosis of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Promising results have recently been obtained on urine survivin as a diagnostic marker of bladder cancer [8]. Quantitative assays of survivin in pleural effusion are additionally useful in lung cancer diagnosis [9]. The serum level of survivin that is measurable before surgical intervention may be useful as a biomarker.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Detection of Serum Survivin and Its Relationship with Prognostic Factors in Ovarian Cancer

Jeon

Kim

et al. 2010

Gynecol Obstet Invest

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Objective: This study was conducted to determine the clinical significance of serum survivin in ovarian cancer. Methods: A total of 65 patients with ovarian tumors including 21 epithelial ovarian cancer, 22 benign epithelial ovarian tumor, 13 dermoid cyst and 9 endometrioma cases were investigated. All histologic types of cancer were serous carcinoma except for 1 case of undifferentiated carcinoma. ELISA was employed to evaluate the serum survivin levels. For statistical analysis, we used Fisher’s exact test, Spearman’s correlation coefficient test, the Mann-Whitney U test, the log-rank test and Cox regression analysis. Results: The survivin level was higher in serous ovarian cancer than in benign epithelial tumors with marginal significance. In ovarian cancer, serum survivin was positively correlated with age, advanced stage and poor disease-free survival. Interestingly, high survivin level positivity was associated with positive peritoneal cytology and omental metastasis of ovarian cancer. Conclusions: Our data collectively suggest that serum survivin reflects the peritoneal metastasis of serous ovarian cancer and may thus be useful as a prognostic biomarker.

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“…Furthermore, studies about survivin expression in pleural effusions are limited [23] [24]. Wu and colleagues [25] have analyzed pleural effusion specimens for survivin expression using ELISA. They reported remarkable sensitivity Interestingly, we were found that compared with primary lung carcinoma (238.66 ± 48.19 pg/ml), Survivin levels were elevated in the group of metastatic other than lung (435.09 ± 320.62 pg/ml, p = 0.033).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Survivin in Pleural Effusion

Xu¹,

Xu²,

Zhao³

et al. 2018

ALC

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Background: Survivin is an inhibitor of apoptosis that may be a novel diagnostic and prognostic marker of cancer. Our study is to investigate the diagnostic and prognostic value of survivin for pleural effusions. Methods: Sixty-five pleural effusion patients were enrolled prospectively. Pleural effusion samples were examined for survivin level by ELISA. Pleural effusions were divided into three groups: Group I, malignant pleural effusion (MPE) (n = 36); Group II, tuberculous pleurisy (TPE) (n = 18); and Group III, transudative pleural effusion (n = 11). The accuracy of diagnosis and the correlation between survivin level and survival in malignant pleural effusions (MPE) were analyzed. Results: Survivin level was 320.50 ± 228.24 pg/ml in MPE, 328.35 ± 146.79 pg/ml in TPE and 318.87 ± 208.39 pg/ml in transudative pleural effusion respectively. ROC curves for MPE versus TPE were analyzed, area under the ROC curve was 0.419, and for the cutoff value of 254.85 pg/ml sensitivity was 44.4% and specificity 55.6%. Survivin had no discriminative power in differentiating exudative effusions of MPE from non-MPE (p = 0.648). There was no correlation between survivin level and age, sex. However, statistically significant difference was found between primary lung carcinoma (238.66 ± 48.19 pg/ml) and extra-pulmonary metastatic carcinomas (435.09 ± 320.62 pg/ml) according to survivin level (p = 0.033). Survivin levels can distinguish patients who had poor prognosis (median survival 96 days) and those who had good prognosis (median survival 206 days) in MPE. Conclusion: survivin levels detected with ELISA had no discriminative power in differentiating exudative effusions included MPE and TPE. However, over-expression of survivin correlates with poor prognosis in cancer patients. Our results suggest that survivin may be a potential prognostic marker in MPE.

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Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Cited by 27 publications

References 26 publications

Elevated survivin is associated with a poor response to chemotherapy and reduced survival in lung cancer with malignant pleural effusions

Elevated survivin is associated with a poor response to chemotherapy and reduced survival in lung cancer with malignant pleural effusions

Quantitative Detection of Serum Survivin and Its Relationship with Prognostic Factors in Ovarian Cancer

Diagnostic and Prognostic Value of Survivin in Pleural Effusion

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