Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma by liquid chromatography–electrospray mass spectrometry

Inoue, Kōichi; Yamaguchi, A.; Wada, Megumi; Yoshimura, Yoshihiro; Makino, Tsunehisa; Nakazawa, Hiroyuki

doi:10.1016/s0378-4347(01)00393-0

Cited by 74 publications

(47 citation statements)

References 22 publications

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“…Unlike these findings, we could detect BPA at a broader range in serum, not just at concentrations around 1 ng/mL. In contrast to our study and the reports of Inoue et al (2001) and Ohkuma H. et al (2002), Fung et al (2000 did not detect BPA in serum of 40 healthy subjects when investigating the pharmacokinetics of BPA released from a dental sealant.…”

Section: Discussioncontrasting

confidence: 99%

Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit

Schönfelder¹,

Wittfoht²,

Hopp³

et al. 2002

Environ Health Perspect

682

322

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Section: Discussioncontrasting

confidence: 99%

Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit

Schönfelder¹,

Wittfoht²,

Hopp³

et al. 2002

Environ Health Perspect

682

322

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“…Serum BPA levels in this sample of pregnant women appeared high, contrasting with findings of 1.49 ± 0.11 and 0.64 ± 0.10 ng/ml, respectively, in a population of Japanese men and women [32]. Studies have reported blood BPA concentrations ranging from below 1 ng/ml to 19 ng/ml in individuals with no intentional exposure [33][34][35], although this wide variation may be related to the different BPA quantification method used. These www.witpress.com, ISSN 1743-3541 (on-line) data suggest that children may also be exposed to BPA during pregnancy.…”

Section: Discussioncontrasting

confidence: 97%

“…GC-MS analysis was performed using a 6890 Agilent (Agilent Technologies, Wilmington, USA) gas chromatograph with a 7683 series injector and a quadruple mass filter 5976 network mass selective detector (MSD) following a previously published method [33]. In brief, a ZB-5 MS Zebron capillary column (30 m×0.25 mm i.d.…”

Section: Apparatus: Gas Chromatography-mass Spectrometry Analysismentioning

confidence: 99%

Alkylphenols and bisphenol-A and its chlorinated derivatives in adipose tissue of children

Olea

Arrebola

Taoufiki

et al. 2008

WIT Transactions on Ecology and the Environment

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Bisphenol-A (BPA) is a plastic monomer and plasticizer used in the production of polycarbonate and epoxy resins. Alkylphenols are used as antioxidants and in the synthesis of industrial detergents, in toiletries, and as spermicides. Because of their endocrine disrupting properties, there is strong interest in studying their contribution to human exposure, especially in children. Octyl (OP) and nonylphenol (NP), bisphenol-A (BPA) and its chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of 86 children in Spain. OP and NP were above the limit of detection (LOD) in 21 and 31 out of 86 samples, respectively. Means (SD) of OP and NP were 6.27 (6.63) and 38.27 (56.91) ng/g of adipose tissue, respectively. BPA was above LOD in 53 out of 86 samples (62%). Among Cl(x)BPA, Cl2-BPA was the most frequent (99%) and abundant, followed by Cl-BPA (64%) and Cl4-BPA (12%). Means (SD) of BPA, Cl-BPA, Cl2-BPA, Cl3-BPA and Cl4-BPA were 17.46 (14.82), 7.32 (4.26), 14.45 (9.79), 4.14 (1.35) and 3.54 (1.94) ng/g, respectively. There are no published data on alkylphenols and BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. However, these levels are higher than BPA concentrations reported to stimulate molecular endpoints in vitro and are at levels observed to induce effects in animal models. Further research is needed to explore their combined effects on children health, and to follow trends in human exposure if uses of these chemicals are to be regulated.

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“…Seventeen studies have measured BPA in blood and serum samples from healthy male and nonpregnant female adults (Dirtu et al 2008;Fung et al 2000;He et al 2009;Hiroi et al 2004;Ikezuki et al 2002;Inoue et al 2000Inoue et al , 2001Kaddar et al 2009;Kuroda et al 2003;Liu et al 2007;Sajiki et al 1999;Sugiura-Ogasawara et al 2005;Takeuchi and Tsutsumi 2002;Takeuchi et al 2004;Volkel et al 2005;Yang M et al 2009;Yoshimura et al 2002) (Table 3). Of these studies, five used ELISA, one used a radioimmunoassay (RIA), and the remainder used analytical chemistry to assess BPA concentrations.…”

Section: Internal Dosage Assessment From Blood Measures Of Bpamentioning

confidence: 99%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

332

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma by liquid chromatography–electrospray mass spectrometry

Cited by 74 publications

References 22 publications

Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit

Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit

Alkylphenols and bisphenol-A and its chlorinated derivatives in adipose tissue of children

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

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