Quantitative data on the size of synaptic end‐bulbs in the cat's spinal cord. With a note on the preparation of cell models

Haggar, Robert A.; Barr, Murray L.

doi:10.1002/cne.900930103

Cited by 42 publications

(8 citation statements)

References 25 publications

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“…Synaptic boutons on motoneurones abundantly cover the surface of motoneurones (Hagger & Barr, 1950), and, as a consequence, if neurotransmitters from single quanta saturate postsynaptic receptors (Tang et al, 1994), then transmitter could diffuse to neighbouring synapses (Barbour et al, 1994). Thus it is possible that glycine diffuses from its synapse to nearby glutamatergic synapses.…”

Section: Resultsmentioning

confidence: 99%

Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones

Umemiya¹,

Berger²

1995

British J Pharmacology

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Section: Resultsmentioning

confidence: 99%

Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones

Umemiya¹,

Berger²

1995

British J Pharmacology

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“…Suggestive evidence for this notion has been provided recently by the high m values of monosynaptic EPSPs recorded from neurones in Clarke's column (Eide, Fedina, Jansen, Lundberg & Vyklick'Y, 1967;Kuno & Miyahara, 1968a), which coincides with the presence of giant synaptic contacts on these neurones (Szentagothai & Albert, 1955). In this respect, it is rather surprising that the m value of EPSPs in spinal motoneurones shows such wide variation, since the presynaptic terminals on the motoneurone are relatively uniform in size (Haggar & Barr, 1950;Wyckoff & Young, 1956;Illis, 1964;Gelfan & iRapisarda, 1964). It is suggested that the variation of the m value is due to the difference in the number of afferent terminal branchings on a motoneurone (also, see Kuno, 1964a;Burke & Nelson, 1966).…”

Section: Discussionmentioning

confidence: 99%

Analysis of synaptic efficacy in spinal motoneurones from ‘quantum’ aspects

Kuno¹,

Miyahara²

1969

The Journal of Physiology

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SUMMARY1. Synaptic responses of triceps surae motoneurones of the cat following stimulation of single afferent fibres were examined by intracellular recording techniques.2. The mean quantum content (m) of monosynaptic excitatory postsynaptic potentials (EPSPs) was independent of the type of motoneurone recorded and of the afferent fibre stimulated. There was no significant difference in m value between homonymous and heteronymous synapses. 3. A positive correlation was found between the amplitude of unit EPSPs and the input resistance of motoneurones. The difference in the amplitude of unit EPSPs appears to be responsible for the higher synaptic efficacy in slow-conducting motoneurones than in fast-conducting motoneurones.4. There was no significant difference in the time course of monosynaptic EPSPs evoked by impulses from homonymous and heteronymous afferent fibres.5. The ratio of monosynaptic connexions from a given afferent fibre was significantly greater on to homonymous than to heteronymous motoneurones. It is concluded that the difference in efficacy between homonymous and heteronymous synaptic transmission is due to the difference in the number of afferent fibres converging upon these motoneurones.

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“…It has recently been shown that m values of the monosynaptic response observed in Clarke's column neurones are significantly greater than those measured in spinal motoneurones (Kuno & Miyahara, 1969;Eide, Fedina, Jansen, Lundberg & Vyklicky, 1969). A substantial number of synaptic endings on Clarke's column neurones are 5-15 # in diameter (Szentagothai & Albert, 1955), whereas those on spinal motoneurones usually range from 0-5 to 3 ,t (Haggar & Barr, 1950). Thus, these observations are compatible with the notion that the number of quanta of transmitter released by a nerve impulse may be related to the size of the presynaptic terminals (see also Miledi, 1967;R.…”

Section: Introductionmentioning

confidence: 99%

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog

Kuno¹,

Turkanis²,

Weakly³

1971

The Journal of Physiology

286

134

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SUMMARY1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium.2. The muscle was subsequently subjected to 'cholinesterase staining', and the area of the individual end-plates, studied with intracellular electrodes, was measured.3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.4. The mean quantum content (m) showed a positive correlation with the size of end-plates.5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.

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Quantitative data on the size of synaptic end‐bulbs in the cat's spinal cord. With a note on the preparation of cell models

Cited by 42 publications

References 25 publications

Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones

Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones

Analysis of synaptic efficacy in spinal motoneurones from ‘quantum’ aspects

Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog

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