Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements

Abstract

The clinical interpretation of plasma micronutrients can be made only with knowledge of the degree of inflammatory response. A reliable clinical interpretation can be made only if the C-reactive protein is <20 mg/L (plasma zinc), <10 mg/L (plasma selenium and vitamins A and D), or <5 mg/L (vitamins B-6 and C).

Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China

“…Firstly, the serum levels of trace elements in patients were tested after the diagnosis of breast cancer, but before therapy. Injuries and infections were reported to alter concentrations of a variety of micronutrients (Duncan et al 2012). Nevertheless, our findings still offer a direction to future prospective researches in China as well as in other regions and countries.…”

The relationship between acute changes in the systemic inflammatory response and plasma ascorbic acid, alpha-tocopherol and lipid peroxidation after elective hip arthroplasty

“…They postulated that these findings could be attributed to redistribution, overhydration and increased requirements for antioxidants. More recently Duncan and coworkers (2012) reported that in a large cohort of patients, there was a larger fall of 78% in plasma AA for CRP concentrations of >80 mg/l [4].…”

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

“…6 Indeed, recent studies have quantified the impact of the systemic inflammatory response, as evidenced by both serum C-reactive protein (CRP) and albumin, on serum vitamins and micronutrients. [7][8] With reference to iron status, hepcidin is a key regulator of iron homeostasis, acting to reduce iron export and cause sequestration of iron through the inhibition of ferroportin.…”