Quantitative CT Scanning Analysis of Pure Ground-Glass Opacity Nodules Predicts Further CT Scanning Change

Bak, So Hyeon; Lee, Ho Yun; Kim, Jae‐Hun; Um, Sang‐Won; Kwon, O Jung; Han, Joungho; Kim, Hong Kwan; Kim, Young Tae; Lee, Kyung Soo

doi:10.1378/chest.15-0034

Cited by 79 publications

(84 citation statements)

References 31 publications

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“…In the study conducted by Kobayashi et al (20), the number of nodules is 120, which is about twice the number of patients. Four studies (12)(13)(14)(15) only included pure GGNs, and the other six studies (16)(17)(18)(19)(20)(21) included both pure GGNs and part-solid GGNs. The results of five studies (16)(17)(18)(19)(20) were based on all types of SSNs, while one study (21) was based on each type of SSNs.…”

Section: Subjectsmentioning

confidence: 99%

Section: Ct Parametersmentioning

confidence: 99%

“…Three studies (12,13,18) used a single CT scan, five studies (15-17, 20, 21) used two different CT scans, and two studies (14,19) used three different CT scans ( Table 1). Only one study (12) showed all reconstruction algorithms using a bone algorithm. Three studies (13,14,16) only used a single reconstruction thickness, which was 2, 1.25, and 1 mm, for the respective studies.…”

Section: Ct Parametersmentioning

confidence: 99%

“…Three studies (15,19,20) defined a change in SSNs as an increase in diameter ≥2 mm. Three different studies (12)(13)(14) defined a change in SSNs using the parameter above and/or the presence of an emerging solid portion. Two more studies (18, 21) defined a change in SSNs as the two parameters mentioned above and/or an increase in the solid parts' size.…”

Section: Definitions Of Ssn Changesmentioning

confidence: 99%

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The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

Gao

Kong

et al. 2020

Front. Oncol.

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Background: The detection rate for pulmonary nodules, particularly subsolid nodules (SSNs), has been significantly improved. The purpose of this review is to summarize the relationship between quantitative features of initial CT imaging and the subsequent natural growth of SSNs to explore potential reasons for these findings. Methods: Relevant studies were collected from a literature search of PubMed, Embase, Web of Science, and Cochrane. Data extraction was performed on the patients' basic information, CT methods, and acquisition methods, including quantitative CT features, and statistical methods. Results: A total of 10 relevant articles were included in our review, which included 850 patients with 1,026 SSNs. Overall, the results were variable, and the key findings were as follows. Seven studies looked at the relationship between the diameter and growth of SSNs, showing that SSNs with larger diameters were associated with increased growth. An additional three studies which focused on the relationship between CT attenuation and the growth of SSNs showed that SSNs with a high CT attenuation were associated with increased growth. Conclusion: CT attenuation may be useful in predicting the natural growth of SSNs, and mean CT attenuation may be more useful in predicting the natural growth of pure ground glass nodules (GGNs) than part-solid GGNs. While evaluation by diameter did have some limitations, it demonstrates value in predicting the growth of SSNs.

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Section: Subjectsmentioning

confidence: 99%

Section: Ct Parametersmentioning

confidence: 99%

Section: Ct Parametersmentioning

confidence: 99%

Section: Definitions Of Ssn Changesmentioning

confidence: 99%

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The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

Gao

Kong

et al. 2020

Front. Oncol.

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“…Early pulmonary cancer mainly originates in bronchial epithelium, with the involvement of centrilobular bronchi or centrilobular arterial nodules, and located around the blood vessels, around or through the minimum pulmonary arteries that CT show. The adjustment of the pulmonary window width and window level can distinguish the imaging range of GGO from blood vessels and bronchi to improve the accuracy of clinical diagnosis (11,12). The common parameter is window width of 800–1,000 HU, window level of −700 HU, and upper bound of −200 HU.…”

Section: Discussionmentioning

confidence: 99%

Value of window technique in diagnosis of the ground glass opacities in patients with non-small cell pulmonary cancer

Yao

2016

Oncology Letters

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The aim of the present study was to examine the value of window technique in qualitative diagnosis of the ground glass opacities (GGO) in patients with non-small cell pulmonary cancer. A total of 124 clinically suspected pulmonary cancer patients were analyzed retrospectively. The lesions were affirmed by puncture biopsy, and were GGO on pulmonary window while were invisible on mediastinal window. Sixty-four multi-detector spiral computed tomography with the window width and window level of 1,500 Hounsfield units (HU) and −450 HU on pulmonary window, while the window width and window level of 400 and 40 HU on mediastinal window, was used in the study. The window adjustment technique was used to analyze the window width and window level of lesion on pulmonary window and mediastinal window, for searching invisible threshold on 3-megapixel medical displays. The diagnostic accuracy and the cut-off value were compared on receiver operating characteristic (ROC) curve. The results showed that the window width and window level on pulmonary window and mediastinal window of malignant lesions were significantly less than those of benign ones (P<0.05). The cut-off value on pulmonary window was the window width and window level of 1,300 and −220 HU, the area under the ROC was 0.830 [sensitivity was 72.5%, specificity was 84.3%; 95% confidence interval (CI), 0.712–0.945]. The cut-off value on mediastinal window was the window width and window level of 360 and 30 HU, and the area under the ROC was 0.623 (was 62.0%, specificity was 55.7%; 95% CI, 0.541–0.745). In conclusion, the window technique has high sensitivity and accuracy in qualitative diagnosis of the GGO.

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Anti‐MDA‐5 antibody‐positive clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease treated with therapeutic plasma exchange: A case series

Saito

Mizobuchi

Miwa

et al. 2020

J of Clinical Apheresis

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We present six cases of antimelanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab)-positive clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP-ILD), which is known to have a poor prognosis. The outcomes of these cases are described after treatment with therapeutic plasma exchange (TPE). Clinical and therapeutic data for patients with CADM with RP-ILD were collected retrospectively from medical records. All six patients received early intensive care including high-dose corticosteroids, intravenous cyclophosphamide, and a calcineurin inhibitor, but lung disease and hypoxia became more severe. TPE was performed over a median of 9.5 sessions (range 3-14) per patient, and the median duration from admission to TPE was 23 days. Three patients received combined direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP) therapy on successive days to manage acute respiratory failure. Four patients survived and two died due to respiratory failure. In the survival cases, ferritin decreased, and ferritin and KL-6 were lower at diagnosis. The patients who died had a higher alveolar-arterial oxygen difference and more severe lung lesions at the time of initiation of TPE. These findings indicate that a combination of conventional therapy and TPE may be useful for improvement of the prognosis of CADM with RP-ILD at the early stage of onset.

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Quantitative CT Scanning Analysis of Pure Ground-Glass Opacity Nodules Predicts Further CT Scanning Change

Cited by 79 publications

References 31 publications

The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

Value of window technique in diagnosis of the ground glass opacities in patients with non-small cell pulmonary cancer

Anti‐MDA‐5 antibody‐positive clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease treated with therapeutic plasma exchange: A case series

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