Quantitative CT detects progression in COPD patients with severe emphysema in a 3-month interval

Konietzke, Philip; Wielpütz, Mark O.; Wagner, Willi L.; Wuennemann, Felix; Kauczor, Hans‐Ulrich; Eichinger, Monika; Eberhardt, Ralf; Gompelmann, Daniela; Weinheimer, Oliver

doi:10.1007/s00330-019-06577-y

Cited by 39 publications

(33 citation statements)

References 49 publications

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“…Multi-detector computed tomography is the reference modality for airway imaging, and various software tools allow the quantification of airway dimensions [ 4 – 7 , 19 ]. Computational airways measurements are still mainly used in scientific contexts, for example, in chronic obstructive pulmonary disease (COPD) [ 31 , 36 ], bronchial asthma (BA) [ 5 , 16 ], or cystic fibrosis (CF) [ 10 ]. These measurements are usually based on non-enhanced data, since intravenous iodinated contrast material influences the attenuation values of airways and thus the results of airway measurements.…”

Section: Discussionmentioning

confidence: 99%

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

et al. 2020

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Introduction Quantitative analysis of multi-detector computed tomography (MDCT) plays an increasingly important role in assessing airway disease. Depending on the algorithms used, airway dimensions may be over-or underestimated, primarily if contrast material was used. Therefore, we tested a modified integral-based method (IBM) to address this problem. Methods Temporally resolved cine-MDCT was performed in seven ventilated pigs in breath-hold during iodinated contrast material (CM) infusion over 60s. Identical slices in non-enhanced (NE), pulmonary-arterial (PA), systemic-arterial (SA), and venous phase (VE) were subjected to an in-house software using a standard and a modified IBM. Total diameter (TD), lumen area (LA), wall area (WA), and wall thickness (WT) were measured for ten extra-and six intrapulmonary airways. Results The modified IBM significantly reduced TD by 7.6%, LA by 12.7%, WA by 9.7%, and WT by 3.9% compared to standard IBM on non-enhanced CT (p<0.05). Using standard IBM, CM led to a decrease of all airway parameters compared to NE. For example, LA decreased from 80.85±49.26mm 2 at NE, to 75.14±47.96mm 2 (-7.1%) at PA (p<0.001),

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Section: Discussionmentioning

confidence: 99%

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

et al. 2020

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“…[ 69 ] Quantitative CT (QCT) can detect short-time progression of emphysema in severe COPD. [ 70 ] The changes partly differed among lung lobes and airway generations, indicating QCT as a useful method to address the heterogeneity of COPD.…”

Section: Clinical Application Of Ct In Small Airway Detectionmentioning

confidence: 99%

Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease

Zhou

et al. 2021

Chinese Medical Journal

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Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characteristic of small airway inflammation, obstruction, and emphysema. It is well known that spirometry alone cannot differentiate each separate component. Computed tomography (CT) is widely used to determine the extent of emphysema and small airway involvement in COPD. Compared with the pulmonary function test, small airway CT phenotypes can accurately reflect disease severity in patients with COPD, which is conducive to improving the prognosis of this disease. CT measurement of central airway morphology has been applied in clinical, epidemiologic, and genetic investigations as an inference of the presence and severity of small airway disease. This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.

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“…In COPD the bronchial dimensions were shown to depend on the smoking status and smokinginduced airway remodeling was partially reversible after smoking cessation even in long-term heavy smokers [19]. Further, it was demonstrated that short-time airway geometry changes can be detected in severe COPD with quantitative CT [20]. Therefore, huge efforts have been made to develop radiological measurement methods using CT, such as non-invasive 3D measurements and quantifications of airway geometry and lung parenchyma aiming to advance diagnostic and prognostic methodologies for several diseases like asthma, emphysema, COPD and cystic fibrosis [10][11][12][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Comparison of histological and computed tomographic measurements of pig lung bronchi

Schmitt

Schmitt²,

Hollemann³

et al. 2020

ERJ Open Res

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AimLight microscopy is used as template in the evaluation and further development of medical imaging methods. Tissue shrinkage caused by histological processing is known to influence lung tissue dimensions. In diagnostic of chronic obstructive pulmonary disease, computed tomography (CT) is widely used for automated airway measurement. We compared the bronchus wall thickness in histological and different image analysis methods.MethodsAirway measurements of pig lungs were performed after freezing under controlled inflation pressure in a liquid nitrogen bath. The wall thickness of seven bronchi was measured via MicroCT and CT using the integral based method (IBM) and the full-width-at-half-maximum method (FWHM) automatically and histologically on frozen and paraffin sections. Statistical analysis was performed using the Wilcoxon test, Pearson's correlation coefficient with a significance level at p<0.05, scatter plots and Bland Altman plots.ResultsBronchus wall thickness was smallest in frozen sections (median 0.71 mm) followed by paraffin sections (median 0.75 mm), MicroCT (median 0.84 mm) and CT measurements using IBM (median 0.68 mm) and FWHM (median 1.69 mm). Statistical significant differences were found among all tested groups (p<0.05) except for CT IBM and paraffin and frozen sections and MicroCT. High correlation was present between all parameters with statistical significance (p<0.05).ConclusionsSignificant differences in airway measurement were found in the different analysing methods. The absolute measurements with CT IBM were closest to the histological results followed by MicroCT, whereas CT FWHM revealed a distinct divergence to the other groups.

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Quantitative CT detects progression in COPD patients with severe emphysema in a 3-month interval

Cited by 39 publications

References 49 publications

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography

Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease

Comparison of histological and computed tomographic measurements of pig lung bronchi

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