Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD

Rutten, Erica P.A.; Grydeland, Thomas Blix; Pillai, Sreekumar; Wagers, Scott; Dirksen, Asger; Gulsvik, Amund; Wouters, Emiel F.M.; Bakke, Per

doi:10.1155/2011/419328

Cited by 35 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This has been demonstrated in other studies of chronic airway diseases, including tobacco-[23, 24] and wood smoke-related COPD [25, 26]. In our classification of WTC-related airway disorders [1], a substantial proportion of cases does not meet established criteria for the diagnoses of asthma or COPD, but are instead diagnosed with non-specific chronic bronchitis or bronchiolitis, based on the presence of lower respiratory symptoms, non-specific lung function abnormalities, and/or chest CT imaging evidence of end-expiratory air trapping [1, 2, 8].…”

Section: Discussionsupporting

confidence: 66%

Increased Airway Wall Thickness is Associated with Adverse Longitudinal First–Second Forced Expiratory Volume Trajectories of Former World Trade Center workers

Hoz

Liu

Doucette

et al. 2018

Lung

View full text Add to dashboard Cite

Rationale Occupational exposures at the WTC site after September 11, 2001 have been associated with several presumably inflammatory lower airway diseases. In this study, we describe the trajectories of expiratory air flow decline, identify subgroups with adverse progression, and investigate the association of a quantitative computed tomography (QCT) imaging measurement of airway wall thickness, and other risk factors for adverse progression. Methods We examined the trajectories of expiratory air flow decline in a group of 799 former WTC workers and volunteers with QCT-measured (with two independent systems) wall area percent (WAP) and at least 3 periodic spirometries. We calculated individual regression lines for first–second forced expiratory volume (FEV1), identified subjects with rapidly declining and increasing (“gainers”), and compared them to subjects with normal and “stable” FEV1 decline. We used multivariate logistic regression to model decliner vs. stable trajectories. Results The mean longitudinal FEV1slopes for the entire study population, and its stable, decliner, and gainer subgroups were, respectively, −35.8, −8, −157.6, and + 173.62 ml/year. WAP was associated with “decliner” status (ORadj 1.08, 95% CI 1.02, 1.14, per 5% increment) compared to stable. Age, weight gain, baseline FEV1 percent predicted, bronchodilator response, and pre-WTC occupational exposures were also significantly associated with accelerated FEV1 decline. Analyses of gainers vs. stable subgroup showed WAP as a significant predictor in unadjusted but not consistently in adjusted analyses. Conclusions The apparent normal age-related rate of FEV1 decline results from averaging widely divergent trajectories. WAP is significantly associated with accelerated air flow decline in WTC workers.

show abstract

Section: Discussionsupporting

confidence: 66%

Increased Airway Wall Thickness is Associated with Adverse Longitudinal First–Second Forced Expiratory Volume Trajectories of Former World Trade Center workers

Hoz

Liu

Doucette

et al. 2018

Lung

View full text Add to dashboard Cite

show abstract

“…We measured bronchial wall thickening of larger airways using the standardised marker Pi10 which has been shown to correlate with FEV1%29 and is elevated in COPD 30. Our analysis found no significant difference in Pi10 between COPD and controls but did show an association with airflow obstruction.…”

Section: Discussionmentioning

confidence: 59%

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD

Ostridge

Williams

Kim

et al. 2015

Thorax

View full text Add to dashboard Cite

show abstract

“…Another hypothesis suggested emphysema as an autoimmune disease, where protease antiprotease imbalance leads to inflammatory response and therefore tissue destruction is extended from the lungs to whole body soft tissue. 49 However, it remains unclear whether low FFMI contributes to the development of emphysema or whether emphysema leads to the nutritional depletion.…”

Section: Discussionmentioning

confidence: 99%

Fat-Free Mass Index for Evaluating the Nutritional Status and Disease Severity in COPD

Luo

Zhou

et al. 2016

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Despite the high prevalence of weight loss in subjects with COPD, the 2011 COPD management guidelines do not include an index measuring nutritional status. Fat-free mass index (FFMI) can accurately determine the nutritional status of subjects and may be closely correlated with COPD severity. We aimed to determine the nutritional status evaluated by FFMI according to the 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) levels in stable subjects with COPD and the association between nutritional status and respiratory symptoms, exercise capacity, and respiratory muscle function. METHODS: We included 235 stable subjects with COPD in this cross-sectional study. All of the subjects were divided into the 2011 GOLD Groups A, B, C, and D. FFMI (measured by bioelectrical impedance), spirometry (FEV 1 , percent-of-predicted FEV 1 , and FEV 1 /FVC), respiratory muscle function (peak inspiratory and peak expiratory pressures), exercise capacity (6-min walk distance), and dyspnea severity (Modified Medical Research Council dyspnea scale) were measured and compared between the GOLD groups. RESULTS: Malnutrition was identified in 48.5% of subjects and most prevalent in Group D (Group A: 41%, Group B: 41%, Group C: 31%, and Group D: 62%). FFMI was significantly lower in Group D (P < .001), with both sexes considered malnourished. Low FFMI significantly correlated with frequent exacerbation, older age, decreased pulmonary function, 6-min walk distance, peak inspiratory pressure, and worsened dyspnea. FFMI was significantly lower in the emphysemadominant phenotype and mixed phenotype compared with the normal phenotype and airwaydominant phenotype. A stepwise multiple linear regression analysis identified peak inspiratory pressures and older age as independent predictors of FFMI. CONCLUSIONS: Malnutrition is highly prevalent in all COPD groups, particularly in Group D subjects, who warrant special attention for nutritional intervention and pulmonary rehabilitation. FFMI significantly correlated with exercise capacity, dyspnea, respiratory muscle function, and pulmonary function and may be a useful predictor of COPD severity.

show abstract

Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD

Cited by 35 publications

References 20 publications

Increased Airway Wall Thickness is Associated with Adverse Longitudinal First–Second Forced Expiratory Volume Trajectories of Former World Trade Center workers

Increased Airway Wall Thickness is Associated with Adverse Longitudinal First–Second Forced Expiratory Volume Trajectories of Former World Trade Center workers

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD

Fat-Free Mass Index for Evaluating the Nutritional Status and Disease Severity in COPD

Contact Info

Product

Resources

About