Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density

Tang, Zhaomin; Li, Dan; Sun, Huili; Guo, Xing; Chen, Yuping; Zhou, Shaobing

doi:10.1016/j.biomaterials.2014.05.091

Cited by 65 publications

(45 citation statements)

References 60 publications

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“…Active targeting through FAconjugated magnetic NPs is mainly dependent to density of FA on magnetic NPs and FR on the tumor cells as assessed in 4T1 bearing BALB/c mice [74].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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“…Active targeting through FAconjugated magnetic NPs is mainly dependent to density of FA on magnetic NPs and FR on the tumor cells as assessed in 4T1 bearing BALB/c mice [74].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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“…The inhibition of gene delivery by serum is considered to be one of the major limitations for lipoplex application in vivo. 33 . With this in mind, transfection was investigated in the presence of serum.…”

Section: Gene Transfection Efficiency Of Lipoplexesmentioning

confidence: 99%

“…This enforces the idea of the targeted lipoplex being receptor-dependent, which is not the case for untargeted lipoplexes as they lack the receptor specificity. Tang et al 33 noted the increased cell uptake efficiencies at increased FA densities on magnetic nanoparticles (MNPs) in HeLa cells, and postulated that it may be due to the FR-mediated internalization process. Thus, the result of this study demonstrates that the main internalization mechanism of the MSO9 targeted lipoplex is a FR-facilitated endocytosis pathway, specific to FR-overexpressing cells such as HeLa and KB cells.…”

Section: Flow Cytometrymentioning

confidence: 99%

Ligand-Tagged Cationic Liposome Facilitates Efficient Gene Delivery to Folate Receptors

Gorle¹,

Sewbalas²,

Ariatti³

et al. 2016

Current Science

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Non-viral cationic liposome/DNA complexes (lipoplexes) have been used extensively in gene delivery approaches, although they have shown lower efficiency compared to viral carriers. In this study, a rational strategy was employed taking advantage of a combination of cationic liposomes prepared using the cationic cytofectin MSO9 and a folate ligand to create a more selective and effective gene delivery system to target cancer cells that overexpress the folate receptor (

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“…[22][23][24] FA and FA conjugates have a high affinity for FRs and can be transported into the targeting cell through receptor-mediated endocytosis. 25 Thus, FA-modified drug delivery systems can effectively transfer therapeutic agents to tumor cells that highly express FRs.…”

Section: Introductionmentioning

confidence: 99%

Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy

Hong

Sun

et al. 2017

IJN

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Annonaceous acetogenins (ACGs) are a large family of fatty acid derived natural products that are exclusively isolated from the Annonaceae species. Many members of this diverse family have a broad spectrum of biological activities, the most impressive of which is anticancer activity. However, their poor solubility and severe toxicity restrict their clinical application, and their complicated composition hinders their formulation and drug delivery. In this study, β-cyclodextrin was modified with folic acid (FA) and then combined with soybean lecithin to prepare FA-modified ACGs nanosuspensions (FA-ACGs-NSps). The obtained FA-ACGs-NSps had a high drug payload of 57.59% and average particle size of 199.5 nm, and they exhibited sustained drug release within 142 hours. In comparison with ACGs-NSps, FA-ACGs-NSps showed significantly enhanced cytotoxicity and higher cell uptake toward folate receptor-positive 4T1 cell lines. An in vivo study demonstrated that FA-ACGs-NSps more effectively accumulated in tumors and enhanced the antitumor therapeutic efficacy with less toxicity in 4T1 tumor bearing mice. Therefore, FA-ACGs-NSps may be a promising drug delivery system for ACGs to improve their therapeutic window and may be suitable for clinical application to treat folate-positive tumors.

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Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density

Cited by 65 publications

References 60 publications

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

Ligand-Tagged Cationic Liposome Facilitates Efficient Gene Delivery to Folate Receptors

Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy

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