Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus

Luo, Jieli; Chen, Jianshe; Sun, Yang; Zhou, Hang; Xu, Kailun; Huang, Fengbo; Huang, Pintong

doi:10.1007/s00261-019-01908-5

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Besides, PDFI is more sensitive than CDI but is incapable of determining velocity and direction of flow. Contrast-enhanced ultrasound (CEUS) is a technique using microbubbles, which are less than 10 μm in diameter and can pass through capillaries freely, to display microcirculation perfusion [8]. It is currently the "golden standard" for examination of microvasculature with ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor

Shen

2021

Contrast Media & Molecular Imaging

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Background. Renal cell carcinoma is one of the most common malignant tumors in urinary system, seriously affecting people’s health and life. This study aimed to evaluate the clinical value of multi-mode color Doppler flow imaging for diagnosis of solid renal tumor. Methods. Sixty-six renal solid tumors from 63 patients were examined by color Doppler flow imaging (CDFI), power Doppler flow imaging (PDFI), superb microvascular imaging (SMI), and contrast-enhanced ultrasound (CEUS) before surgery. The diagnostic efficacy of the four methods was compared by determining blood flow grade and ring-like blood flow with Adler’s method. Chi-square test and Fisher’s test were performed to compare the results of sensitivity and specificity among four methods. Results. Statistically significant differences in blood flow grade and ring-like blood flow were observed between benign and malignant renal tumors as detected by SMI and CEUS ( P < 0.05), whereas no difference was found as detected by CDFI and PDFI ( P > 0.05). The results indicated that the sensitivity and specificity of SMI (82.46%, 88.89%) and CEUS (84.21%, 88.89%) were higher than those of CDFI (42.11%, 66.67%) and PDFI (47.37%, 77.78%). Compared with the abilities of CDFI and PDFI, SMI and CEUS can better display the micro-blood flow in the tumors and evaluate the blood flow grading, which indicated that SMI and CEUS may have high values in the differential diagnosis of benign and malignant solid renal tumors. Conclusion. SMI and CEUS can improve the sensitivity and specificity of the diagnosis of benign and malignant renal tumors and have a high application value.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor

Shen

2021

Contrast Media & Molecular Imaging

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Contrast-enhanced ultrasound in optimization of treatment plans for diabetic nephropathy patients based on deep learning

Sun

2021

J Supercomput

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The value of contrast-enhanced ultrasound in the diagnosis of microcirculatory perfusion abnormalities in diabetic foot

He,

Yan,

Yuan

et al. 2024

Int J Diabetes Dev Ctries

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Background Diabetic foot is one of the most serious complications of type 2 diabetes mellitus (T2DM), and its incidence is increasing in China. Early detection of abnormal microcirculation in the foot is very important for the prevention and treatment of diabetic foot. Objective To investigate the value of contrast-enhanced ultrasound (CEUS) in diagnosing microcirculatory alterations in the dorsum of the foot for patients with type 2 diabetes mellitus (T2DM). Methods Eighty-eight T2DM patients were included, among them 30 patients sustained diabetes mellitus without complications (group A), 28 with lesions in the dorsum of the foot (no acute infection) that can be classified as Wagner grade 0 ~ 1 (group B), and 30 with lesions in the dorsum of the foot that can be classified as Wagner grade 2–5 (group C). Another 30 healthy adults were included as the control group. All subjects underwent CEUS to examine the dorsalis pedis arteries and blood perfusion to the underlying soft tissues. Parameters of the time-intensity curve (TIC), including rise time (RT), ascending slope (AS), time to peak (TTP), peak intensity (PI), area under the curve (AUC), and half of drop time (DT/2) were analyzed. Results The analysis of TIC data of the dorsalis pedis arteries showed that group C had decreased AS, PI, and AUC and increased TTP, RT, and DT/2 compared with groups A, B, and the control group; the differences were statistically significant (p < 0.05). The analysis of TIC data of the perfusion to the underlying soft tissues showed that AS, PI, and AUC decreased from the control group through group A, B, and then C; the differences were all statistically significant (p < 0.05). The TIC data were correlated with the severity of microcirculatory impairment in the dorsum of the foot and among them the AUC, PI, and AS had higher predictive value. Conclusions Microcirculatory impairment in the dorsum of the foot in T2DM patients presents itself as “delayed wash-in, delayed wash-out, and weak enhancement” on CEUS images. CEUS can provide quantification of the microcirculatory changes in the soft tissues in the dorsum of the foot and reflect the differences of microcirculatory perfusion across different grades of lesions.

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Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus

Cited by 3 publications

References 36 publications

Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor

Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor

Contrast-enhanced ultrasound in optimization of treatment plans for diabetic nephropathy patients based on deep learning

The value of contrast-enhanced ultrasound in the diagnosis of microcirculatory perfusion abnormalities in diabetic foot

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