Quantitative computed tomography in assessment of osteoporosis

Genant, Harry K.; Block, Jon E.; Steiger, Peter; Glueer, Claus-Christian; Smith, R. W.

doi:10.1016/s0001-2998(87)80024-7

Cited by 127 publications

(91 citation statements)

References 52 publications

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“…Moreover, the ScoutViewTM facilitates repeated measurements of the same site, and the cortical and cancellous bone can be assessed separately. The precision of QCT has been found to be 1.54% (Genant et al 1987, SBU 1995. In the equipment used in this study, we have found about the same precision (2-5%).…”

Section: Discussionmentioning

confidence: 98%

“…The method used in this study, QCT, implemented by Riiegsegger et al (1 973) and further developed by Genant et al (1987), has several advantages compared to other bone assessment methods. It measures the true BMD (g/cm3) and not as single-photon absorptiometry or dual-energy X-ray absorptiometry (DEXA), the areal BMD (g/cm2).…”

Section: Discussionmentioning

confidence: 99%

“…This finding indicates that the cortical bone is less sensitive to different forms of osteopenia. The cancellous bone, because of its high surface-to-volume ratio, has a presumed turnover rate about 8 times that of cortical bone and is highly responsive to various stimuli (Falch et al 1985, Genant et at. 1987, Akesson 1995.…”

Section: Discussionmentioning

confidence: 99%

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Decrease in bone mineral density and muscle mass after femoral neck fracture: A quantitative computed tomography study in 25 patients

Neander

Adolphson

Hedström

et al. 1997

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decrease in bone mineral density and muscle mass after femoral neck fracture: A quantitative computed tomography study in 25 patients

Neander

Adolphson

Hedström

et al. 1997

Acta Orthopaedica Scandinavica

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“…It has been reported that QCT might be most sensitive to changes in bone density caused by rapid bone turnover, such as in menopausal immobilization or hyperthyroidism [9]. QCT can selectively measure both trabecular and cortical bone [9,13,22,38], and the BMD is expressed in milligrams per cubic centimeter (volumetric density) [9]. Ebbesen et al showed highly correlation between BMD by QCT and compressive strength in the lumbar vertebrae [9].…”

mentioning

confidence: 99%

Age-Related Changes of Bone Mineral Density and Microarchitecture in Miniature Pigs

Inui

Itamoto

Takuma³

et al. 2004

J. Vet. Med. Sci.

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ABSTRACT. Bone mineral density (BMD), distribution of its density and bone histomorphometric parameters were evaluated in lumbar vertebra of normally growing miniature pigs. The fourth lumbar vertebra (L4) of the Göttingen miniature pig were used in this cross-sectional study in vitro. The BMD of the miniature pig was similar to that of humans in tendency of gender differences and some growth patterns during puberty. In these regards this animal appears useful as a model for human bone study. However, the trabecular and cortical BMDs of lumbar spine were extremely high value (399.43 ± 26.36 mg/cm 3 in female trabeculae; 973.06 ± 69.55 mg/cm 3 in female cortical bone; 419.04 ± 34.84 mg/cm 3 in male trabeculae; 1038.81 ± 125.72 mg/cm 3 in male cortical bone in pigs 30 months or more). Furthermore, histomorphometric analysis yielded values that were remarkably different from those found in humans. From these results, it was revealed that miniature pig had a higher bone mass and denser trabecular network than human, indicating that its bone is probably stronger. Therefore, care should be taken in choosing the miniature pig as a bone study model. KEY WORDS: bone mineral density, histomorphometric analyses, lumbar spine, miniature pig.J. Vet. Med. Sci. 66(6): 599-609, 2004 Metabolic bone diseases such as osteoporosis are becoming more important because of an aging society in human medicine. These diseases increase the risk of fragility fracture as bone mineral levels decrease, and also reduces their quality of life. Previous studies have reported that bone strength and fracture risk are closely related to bone mineral density (BMD) [6,9,27]. In contrast, several studies have suggested that changes in bone architecture increase fracture risk [29,31,33,34,43]. Therefore, it is necessary to study the changes in both BMD and architecture for more sensitive investigation of the bone disease.Quantitative computed tomography (QCT) has been widely investigated and applied in recent years as a means of non-invasive quantification of BMD. It has been reported that QCT might be most sensitive to changes in bone density caused by rapid bone turnover, such as in menopausal immobilization or hyperthyroidism [9]. QCT can selectively measure both trabecular and cortical bone [9,13,22,38], and the BMD is expressed in milligrams per cubic centimeter (volumetric density) [9]. Ebbesen et al. showed highly correlation between BMD by QCT and compressive strength in the lumbar vertebrae [9].Several studies have reported that bone disorders such as osteoporosis lead to trabecular and cortical bone alterations in humans. These alterations are characterized not only by a reduction of bone mass but also by structural changes in microarchitecture which is measured by histomorphometry of bone [29,31,33]. Therefore, it has been considered that histomorphometric analysis have an important role as contributor to bone strength, in addition to BMD.Recently, miniature pig has been noticed as for experimental animal of bone study. The pig is an excel...

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“…Quantitative computed tomography (QCT) is the adaptation of computed tomography for the measurement of bone density (8)(9)(10)(11). Unlike DPA, QCT measurements of bone density are 3-dimensional volumetric measurements.…”

Section: Quantitative Computed Tomographymentioning

confidence: 99%

Application and Interpretation of Bone Densitometry in Modern Medicine

Bonnick

1996

Baylor University Medical Center Proceedings

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Quantitative computed tomography in assessment of osteoporosis

Cited by 127 publications

References 52 publications

Decrease in bone mineral density and muscle mass after femoral neck fracture: A quantitative computed tomography study in 25 patients

Decrease in bone mineral density and muscle mass after femoral neck fracture: A quantitative computed tomography study in 25 patients

Age-Related Changes of Bone Mineral Density and Microarchitecture in Miniature Pigs

Application and Interpretation of Bone Densitometry in Modern Medicine

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