Quantitative computed tomography imaging in asthma and chronic obstructive pulmonary disease.

Obojski, Andrzej; Patyk, Mateusz; Parkitna-Patyk, Martyna; Sokołowska-Dąbek, Dąbrówka; Zaleska-Dorobisz, Urszula

doi:10.1183/13993003.congress-2018.oa3796

Cited by 3 publications

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“…As the future work, an experimental validation of the method by comparing its outcomes with the results of high-resolution computed tomography performed synchronously with the bronchial tests is planned [41], [42], as well as clinical trials with a larger group of subjects (preferably suffering from asthma and COPD) and different drugs inhaled.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of the Airway Response to Bronchial Tests Based on a Spirometric Curve Shift

Polak

Obojski

Mroczka

2021

IEEE Trans. Biomed. Eng.

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Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of the Airway Response to Bronchial Tests Based on a Spirometric Curve Shift

Polak

Obojski

Mroczka

2021

IEEE Trans. Biomed. Eng.

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“…The structural changes found on pathological examination of the remodelled airway wall have been shown to display similarities but also differences [31]. O bojski et al [32] evaluated the intensity of remodelling of bronchi in SRA and COPD patients using QCT, and aimed at establishing a relationship between remodelling and airflow limitation. They recruited 10 SRA patients, 12 COPD patients and 11 healthy individuals with no respiratory or smoking history, who underwent chest CT and pulmonary function tests.…”

Section: Group 13: Imagingmentioning

confidence: 99%

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly

et al. 2019

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This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care. The newest research, actual data and highlight sessions will be discussed.

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Quantitative assessment of the airway response to bronchial tests based on a spirometric curve shift

Polak¹,

Obojski²,

Mroczka³

2020

Preprint

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Objective: Although spirometry is the most common pulmonary function test, there is no method to quantitatively infer about airway resistance or other properties from the flow-volume curves. Recently, an identifiable inverse model for forced expiration was proposed, as well as the idea to deduce changes in airway resistances and compliances from spirometric curve evolution. The aim of this work was to combine the above advances in a method for assessing the airway response to bronchial tests from a spirometric curve shift. Methods: The approach is based on the differential measurement of the degree, site of maximal effect and width of changes, further recalculated into relative changes in the distribution of airway resistances (δRg) and compliances (δCg) along the bronchial tree. To this end, appropriate models were identified using the pre- and post-test spirometry data. The accuracy was validated using sets of data simulated by the anatomy and physiology based models. Finally, the method was used to analyze the bronchodilation tests of three asthmatic subjects. Results: The expected errors in assessing the degree, site and width of changes in the zone of conducting airways were 6.3%, 2.4 generations and 22%, respectively, and for δRg and δCg were 5-10% and 13-16%, respectively. The analyses of clinical data indicated a significant reduction in resistances and an increase in compliances of airway generations 8-12, consistent with clinical knowledge. Conclusion: An unprecedented method to plausibly transforming the spirometry data into the site and degree of changes in airway properties has been proposed. Significance: The method can be used to deduce about the effects of bronchial tests, as well as to monitor changes in the airways between visits or to investigate how inhaled pharmaceuticals affect the bronchi.

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Quantitative computed tomography imaging in asthma and chronic obstructive pulmonary disease.

Cited by 3 publications

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Quantitative Assessment of the Airway Response to Bronchial Tests Based on a Spirometric Curve Shift

Quantitative Assessment of the Airway Response to Bronchial Tests Based on a Spirometric Curve Shift

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly

Quantitative assessment of the airway response to bronchial tests based on a spirometric curve shift

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