Quantitative computed tomography features and clinical manifestations associated with the extent of bronchiectasis in patients with moderate-to-severe COPD

Bak, So Hyeon; Kim, Soohyun; Hong, Yoonki; Heo, Jeongwon; Lim, Myoung-Nam; Kim, Woo Jin

doi:10.2147/copd.s157953

Cited by 10 publications

(17 citation statements)

References 42 publications

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“…Of all of these, 14 duplicates were removed. After reviewing the titles and abstracts, 76 full-text articles were identified and reviewed, and, finally, 18 studies 11,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] were included in this systematic review and meta-analysis. The flow diagram of article selection according to the PRISMA guideline 13 is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 415,257 subjects with COPD from 18 observational studies 11,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] were eligible for this meta-analysis, and bronchiectasis was present in 25,929 subjects (6.24%). The sample size ranged from 54 to 386,646, and 6 studies [17][18]20,22,25,33 had a small population (N < 100).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The sample size ranged from 54 to 386,646, and 6 studies [17][18]20,22,25,33 had a small population (N < 100). Ten studies 11,[17][18][19][20]25,[27][28][32][33] were prospective (cohort studies) and 8 [21][22][23][24]26,[29][30][31] were retrospective (case-control studies) in design. The minimum study duration lasted for 1 year and the maximum lasted for 10 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Impact of Radiographic Bronchiectasis in COPD

Shi

Wei

et al. 2020

Respir Care

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BACKGROUND: COPD and bronchiectasis frequently coexist, which creates an emerging phenotype with a worse prognosis. However, the impact of bronchiectasis on the natural history of COPD has not been fully evaluated and is still controversial. This meta-analysis was performed to clarify the associations of the presence of bronchiectasis with the prognosis and quality of life of patients with COPD. METHODS: A systematic review and meta-analysis was performed following a search of medical databases, and included articles published up to April 2019. The following outcome measures were analyzed: age, sex, smoking history, body mass index, exacerbation rate, lung function, inflammatory biomarkers, albumin, colonization by potentially pathogenic microorganisms, Pseudomonas aeruginosa isolates, Haemophilus influenzae isolates, hospital admissions, and mortality. RESULTS: A total of 415,257 subjects with COPD from 18 observational studies were eligible; bronchiectasis was present in 25,929 subjects (6.24%). The coexistence of COPD and bronchiectasis occurred more often in older subjects with lower body mass index. The presence of bronchiectasis in the subjects with COPD increased the risk of daily sputum production (odds ratio [OR] 1.80, 95% CI 1.24-2.61), exacerbation (weighted mean difference [WMD] 0.72 times, 95% CI 0.59-0.85), frequent hospital admissions (WMD 0.35 times, 95% CI 0.21-0.49), and follow-up (>3 years) mortality (OR 2.26, 95% CI 0.95-5.36). The subjects with COPD and bronchiectasis showed poorer pulmonary function (FEV 1 /FVC: WMD-3.37%, 95% CI-5.63 to-1.11), lower albumin (Standardized mean difference [SMD]-0.17, 95% CI-0.26 to-0.08), elevated C-reactive protein (SMD 0.40, 95% CI 0.06-0.74), a greater proportion of chronic colonization by potentially pathogenic microorganisms (OR 6.65, 95% CI 4.44-9.95), and a higher isolation rate of P. aeruginosa (OR 5.13, 95% CI 4.89-5.38) or H. influenzae (OR 1.90, 95% CI 1.29-2.79) than the subjects with COPD without bronchiectasis. CONCLUSIONS: This meta-analysis confirmed the significant associations of the presence of bronchiectasis with the natural history, disease course, and outcomes in COPD. The COPDbronchiectasis phenotype had adverse effects on subjects' health condition and prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Impact of Radiographic Bronchiectasis in COPD

Shi

Wei

et al. 2020

Respir Care

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“…Subjects include those having or not having airflow limitations based on spirometry. The protocols of data collection in the CODA cohort were previously described in detail [ 23 – 25 ]. In brief, we obtained data on demographic characteristics, medical history, and environmental exposures from participant questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

et al. 2020

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Background Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investigated the influence of long-term exposure to air pollution on lung function and quantitative imaging measurements in a Korean cohort of participants with and without COPD diagnosis. Methods Study participants (N = 457 including 296 COPD cases) were obtained from the COPD in Dusty Areas (CODA) cohort. Annual average concentrations of particulate matter less than or equal to 10 μm in diameter (PM10) and nitrogen dioxide (NO2) were estimated at the participants’ residential addresses using a spatial air pollution prediction model. All the participants underwent volumetric computerized tomography (CT) and spirometry measurements and completed survey questionnaires. We examined the associations of PM10 and NO2 with FVC, FEV1, emphysema index, and wall area percent, using linear regression models adjusting for age, gender, education, smoking, height, weight, and COPD medication. Results The age of study participants averaged 71.7 years. An interquartile range difference in annual PM10 exposure of 4.4 μg/m3 was associated with 0.13 L lower FVC (95% confidence interval (CI), − 0.22- -0.05, p = 0.003). Emphysema index (mean = 6.36) was higher by 1.13 (95% CI, 0.25–2.02, p = 0.012) and wall area percent (mean = 68.8) was higher by 1.04 (95% CI, 0.27–1.80, p = 0.008). Associations with imaging phenotypes were not observed with NO2. Conclusions Long-term exposure to PM10 correlated with both lung function and COPD-relevant imaging phenotypes in a Korean cohort.

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“…COPD often coexists with other diseases (comorbidities) which may have significant impacts on prognosis of COPD patients. With increasing use of high-resolution computed tomography (HRCT) in assessment of COPD, a high prevalence of previously undiagnosed bronchiectasis was found in COPD patients, ranging from 8.1-69% [7][8][9][10][11][12][13][14][15][16][17][18][19]. Some previous studies suggested the presence of bronchiectasis predicted worse outcome of COPD patients [9-11, 13, 15, 20].Therefore, bronchiectasis was proposed as one of COPD comorbidities by 2014 global initiative for chronic obstructive lung disease (GOLD).…”

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confidence: 99%

Impact of bronchiectasis on long-term survival in patients with acute exacerbation of chronic obstructive pulmonary disease

Zhang

Gao

et al. 2019

Preprint

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Background Only few studies have reported the association between bronchiectasis and mortality in patients with Chronic Obstructive Pulmonary Disease (COPD) and the results were controversial. This study aimed at assessing the prognostic influence of bronchiectasis on COPD patients and comparing differences of prognostic influence of different types of bronchiectasis on COPD patients. Patients and methods This study enrolled patients hospitalized for COPD exacerbation between 2013 and 2014. Bronchiectasis was identified on high-resolution computed tomography (HRCT) within 2 years prior to this hospitalization due to COPD exacerbation and Smith score was used to determine the extent of bronchiectasis. Clinical data were obtained from electronic inpatient medical record. The survival data were obtained through telephone follow-up or electronic medical record. Cox regression analysis was used to assess the prognostic influence of bronchiectasis on COPD patients. Results 748 COPD patients were included in this study. 318 patients were identified to have bronchiectasis. During a median follow-up time of 46 months, 624 COPD patients completed follow-up. There were 210 deaths, 112 of whom were comorbid bronchiectasis patients. Comorbid bronchiectasis patients revealed higher mortality than without bronchiectasis patients in 3 years and the whole follow-up, other than in hospital, 1 year and 2 years. The presence of bronchiectasis and its severity were independently associated with increased mortality of COPD patients. The presence of cystic/varicose bronchiectasis revealed higher mortality than cylindrical bronchiectasis and was independently associated with increased mortality of comorbid bronchiectasis patients. Conclusions The presence of bronchiectasis and its severity were independently associated with increased risk of all-cause mortality and mainly affected the long-term mortality of COPD patients. The presence of cystic/varicose bronchiectasis predicted higher death risk of COPD patients.

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Quantitative computed tomography features and clinical manifestations associated with the extent of bronchiectasis in patients with moderate-to-severe COPD

Cited by 10 publications

References 42 publications

Impact of Radiographic Bronchiectasis in COPD

Impact of Radiographic Bronchiectasis in COPD

Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

Impact of bronchiectasis on long-term survival in patients with acute exacerbation of chronic obstructive pulmonary disease

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