Quantitative Computed Tomography Detects Air Trapping due to Asthma

Newman, Ken; Lynch, David A.; Newman, Lee S.; Ellegood, Denise; Newell, John D.

doi:10.1378/chest.106.1.105

Cited by 236 publications

(166 citation statements)

References 21 publications

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“…Twenty subjects, including 10 asthmatics (7 women and 3 men; age range 20 -35 years; mean age 25 years) and 10 healthy volunteers (6 women and 4 men; age range 21-32 years; mean age 25 years), underwent hyperpolarized 3 He MR lung ventilation imaging. This study was performed under a protocol approved by our local institutional review board, and under a Food and Drug Administration (FDA) approved physician's Investigational New Drug (IND) application for the use of hyperpolarized 3 He.…”

Section: Methodsmentioning

confidence: 99%

“…This study was performed under a protocol approved by our local institutional review board, and under a Food and Drug Administration (FDA) approved physician's Investigational New Drug (IND) application for the use of hyperpolarized 3 He. To evaluate repeatability, 6 of the 10 asthmatics and 4 of the 10 control subjects were imaged twice in a single session, 30 -60 minutes apart.…”

Section: Methodsmentioning

confidence: 99%

“…Chest radiographs offer only gross evaluation of aeration and are not routinely employed in asthma management. Indirect, but more detailed, assessments of ventilation can be made from high resolution CT. Air trapping has been demonstrated by CT even in mild asthmatics, but it is not clear whether these indirect assessments of aeration correlate with asthma severity (2)(3)(4)(5). Pulmonary radionuclide studies can be used to evaluate regional lung ventilation and perfusion.…”

mentioning

confidence: 99%

“…The low proton density results in a weak MR signal, but this limitation can be overcome with a new class of contrast agent, the hyperpolarized gases. Using specialized laser polarizers, two non-radioactive isotopes of noble gases can be polarized, 3 He and 129 Xe. The resulting large non-equilibrium polarization of the nuclei provides sufficient signal to image air spaces despite the low physical density of a gas.…”

mentioning

confidence: 99%

“…The objective of this study was to determine whether hyperpolarized 3 He lung ventilation imaging can detect the reversible ventilation defects that characterize asthma, and whether the imaging findings in asthmatics differ from healthy subjects.…”

mentioning

confidence: 99%

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Hyperpolarized ³He MR lung ventilation imaging in asthmatics: Preliminary findings

Altes

Powers

Knight‐Scott

et al. 2001

Magnetic Resonance Imaging

309

345

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Asthma is a disease characterized by chronic inflammation and reversible obstruction of the small airways resulting in impaired pulmonary ventilation. Hyperpolarized 3 He magnetic resonance (MR) lung imaging is a new technology that provides a detailed image of lung ventilation. Hyperpolarized 3 He lung imaging was performed in 10 asthmatics and 10 healthy subjects. Seven asthmatics had ventilation defects distributed throughout the lungs compared with none of the normal subjects. These ventilation defects were more numerous and larger in the two symptomatic asthmatics who had abnormal spirometry. Ventilation defects studied over time demonstrated no change in appearance over 30 -60 minutes. One asthmatic subject was studied twice in a three-week period and had ventilation defects which resolved and appeared in that time. This same subject was studied before and after bronchodilator therapy, and all ventilation defects resolved after therapy. Hyperpolarized 3 He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy. J. Magn. Reson. Imaging 2001;13: 378 -384.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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