Quantitative computed tomographic study in schizophrenia: cerebral density and ventricle measures

Rossi, Alessandro; Stratta, Paolo; D'Albenzio, L.; Michele, Vittorio Di; Serio, Antonio; Giordano, L.; Petruzzi, Concetta; Casacchia, M

doi:10.1017/s0033291700012381

Cited by 12 publications

(2 citation statements)

References 28 publications

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“…Even within this limitation, it can still be said that, when compared with reports from developed countries, our findings show a lot of biological similarities. For instance, our finding of hyperdensity has been widely reported in studies from developed countries (Largen et aI., 1983(Largen et aI., , 1984Dewan et al, 1983;Rossi et al, 1989). In particular, similar to our findings, the report of Rossi et al, (1989) from Italy indicated that schizophrenics had significantly enlarged third ventricle and hyperdensity in the frontal and parietal regions.…”

Section: Discussionsupporting

confidence: 91%

Computed Tomographic Density Changes in Schizophrenic and Manic Nigerian Subjects

Ohaeri

Adeyinka

Osuntokun

1995

Behavioural Neurology

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There is paucity of computed tomography (CT) studies from developing countries, where schizophrenia is said to have more favourable outcome and present predominantly with positive symptoms. We highlight the densitometric analysis of frontal and parietal areas, assessed by tracing of regions of interest on the slice that passes through the foramen of Monro and the pineal gland. The relationships of the density values with clinical and CT measures were investigated. Fifty schizophrenics, 14 manic and 41 normal subjects were compared. The schizophrenics were assessed with Andreasen's scale for negative symptoms, and outcome was based on the social and clinical condition in the past year. There were no significant differences in mean ages and brain slice area across the groups. In analysis of variance, schizophrenics and manics had significantly higher frontal density than normals. Schizophrenics had significantly higher parietal density than manics and normals (p < 0.001). Parietal density was significantly higher than frontal density, for schizophrenics and normals (p < 0.001). For the patients, density values were not significantly correlated with linear CT measures of atrophy (e.g. ventricle: brain area ratio) and duration of illness. Density values were not significantly associated with outcome, presence of negative symptoms, and visual ratings of cortical sulci and central atrophy. Our findings indicate that schizophrenia in developing countries is also associated with non-specific brain abnormalities.

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Section: Discussionsupporting

confidence: 91%

Computed Tomographic Density Changes in Schizophrenic and Manic Nigerian Subjects

Ohaeri

Adeyinka

Osuntokun

1995

Behavioural Neurology

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“…However, current work suggests a renewed interest in the possibility of substantial parietal involvement in schizophrenia, and this work is implicitly embedded within a network paradigm. For example, recent studies using neuropsychological tests (Buchanan et al, 1994), psychophysiological methods (Buchsbaum et al, 1986), computed tomography (Rossi et al, 1989), magnetic resonance imaging (Harvey et al, 1993), and positron emission tomography (Cleghorn et al, 1989; Schroeder et al, 1994) have detected abnormalities in parietal structure or parietally mediated tasks in schizophrenia patients. Others have noted differential associations between schizophrenia symptoms and parietal deficits and/or levels of activation (Liddle, 1996; Tamminga, Buchanan, & Gold, 1998), with negative symptoms appearing to be functionally localized, in part, to the parietal cortex (Tamminga et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Somatosensory processing in the biological relatives of schizophrenia patients: A signal detection analysis of two-point discrimination.

Lenzenweger¹

2001

Journal of Abnormal Psychology

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This study examined 2-point discrimination performance in 1 st-degree biological relatives (n = 39) of individuals with schizophrenia and normal adult control participants (n = 30) recruited from the community. They completed an objective 2-point discrimination task, adapted for use with a signal detection approach to permit separation of discriminability (i.e., sensitivity, d') from response bias/ criterion (or motivation, lnbeta). Relatives revealed poorer performance on the d' index compared with controls. The 2 groups did not differ on lnbeta, suggesting a genuine difference in sensitivity but not response bias. The sensitivity deficit might reflect decreased spatial acuity and/or impaired intensity cue processing of tactile stimuli. Poor performance on the d' index was most closely associated with 2 schizotypic features, namely "odd beliefs/magical thinking."

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Cerebral Asymmetries in Schizophrenia: Further Evidence for a Lateralization Hypothesis

Rossi

Stratta

1995

Neural Development and Schizophrenia

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Quantitative computed tomographic study in schizophrenia: cerebral density and ventricle measures

Cited by 12 publications

References 28 publications

Computed Tomographic Density Changes in Schizophrenic and Manic Nigerian Subjects

Computed Tomographic Density Changes in Schizophrenic and Manic Nigerian Subjects

Somatosensory processing in the biological relatives of schizophrenia patients: A signal detection analysis of two-point discrimination.

Cerebral Asymmetries in Schizophrenia: Further Evidence for a Lateralization Hypothesis

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