Quantitative Comparison of Retinal Vascular Features in Optical Coherence Tomography Angiography Images From Three Different Devices

Anegondi, Neha; Kshirsagar, Arpita; Mochi, Thirumalesh B; Roy, Abhijit Sinha

doi:10.3928/23258160-20180628-04

Cited by 24 publications

(18 citation statements)

References 26 publications

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“…A comparative study on Indians using the Zeiss Cirrus 5000 showed that the mean FAZ area was 0.35 ± 0.05 mm 2 ; moreover, this value was smaller than that when swept‐source OCT was used and more extensive than that when other spectral devices were used (Anegondi et al. ). In another Chinese study, the mean FAZ area was 0.474 ± 0.172 mm 2 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of foveal avascular zone and retinal vascular density in healthy Chinese and Caucasian adults

Wylęgała

Wang

Zhang

et al. 2019

Acta Ophthalmologica

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Purpose: The aim of this study was to measure and compare the retinal vascular parameters and foveal avascular zone (FAZ) in Chinese and Caucasian populations by using optical coherence tomography angiography (OCT-A). Methods: Fifty-one eyes of Han Chinese and 43 eyes of Caucasians were retrospectively included in our study. The measurements were acquired using Zeiss Cirrus 5000, with the same software version 10 in Poland and China. Results: The size of the FAZ was 0.33 AE 0.012 and 0.28 AE 0.014 mm 2 (p = 0.0289) and the diameter was 2.43 AE 0.06 and 2.18 AE 0.07 mm (p = 0.0057) for Chinese and Caucasian populations, respectively. However, no differences were observed in circularities between the populations. The full Early Treatment of Diabetic Retinopathy Study (ETDRS) vessel length density was significantly different for Chinese (17.05 AE 0.24 mm/mm 2 ) and Caucasian (16.08 AE 0.43 mm/mm 2 ) populations. In addition, the outer ETDRS vessel length density was significantly different for Chinese (16.43 AE 0.42 mm/mm 2 ) and Caucasian (17.47 AE 0.24 mm/mm 2 ) populations, but the central 7.33 AE 1.68 versus 9.32 AE 1.54 mm/mm 2 for the Caucasian and Chinese and inner 16.14 AE 0.52 for Caucasian and 16.93 AE 0.27 mm/mm 2 for Chinese subjects density was not. A significant yet weak positive correlation between FAZ and vessel density was observed (r = 0.216). Furthermore, no significant intersexual differences were observed in study parameters. Conclusion: The Chinese population had larger FAZ with higher vessel length density in the superficial layers of the retina than the Caucasian population.

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Section: Discussionmentioning

confidence: 99%

Comparison of foveal avascular zone and retinal vascular density in healthy Chinese and Caucasian adults

Wylęgała

Wang

Zhang

et al. 2019

Acta Ophthalmologica

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“…To the best of our knowledge, we are not aware of any normal data material available for the different OCTA measurements. Several OCTA vascular quantitative measures currently used in research and has yet to be adopted in clinical practice have been proposed: The area filled by binarized vessels (vessel area density – VD or vessel perfusion density - PD) [57–60];Vessel spacing/inter-capillary area [61];Length of the blood vessel based on the skeletonized OCTA (vascular length density – VLD or skeleton density - SD) [57, 59];Vessel diameter index (VDI) [57];Total length of vessels (vessel length fraction) [62];Vascular architecture and branching, (vessel tortuosity and fractal dimension – FD) [58];Area of the foveal avascular zone – FAZ [63]. …”

Section: Main Textmentioning

confidence: 99%

“…The area filled by binarized vessels (vessel area density – VD or vessel perfusion density - PD) [57–60];…”

Section: Main Textmentioning

confidence: 99%

Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

et al. 2019

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BackgroundDiabetic retinopathy (DR) is a leading cause of vision loss in adults. Currently, the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography. With the introduction of optical coherence tomography angiography (OCTA), it may serve as a potential rapid, non-invasive imaging modality as an adjunct.Main textRecent studies on the role of OCTA in DR include the use of vascular parameters e.g., vessel density, intercapillary spacing, vessel diameter index, length of vessels based on skeletonised OCTA, the total length of vessels, vascular architecture and area of the foveal avascular zone. These quantitative measures may be able to detect changes with the severity and progress of DR for clinical research. OCTA may also serve as a non-invasive imaging method to detect diabetic macula ischemia, which may help predict visual prognosis. However, there are many limitations of OCTA in DR, such as difficulty in segmentation between superficial and deep capillary plexus; and its use in diabetic macula edema where the presence of cystic spaces may affect image results. Future applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular glaucoma.ConclusionOCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the future. Future studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes.

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“…The main types of OCTA that are commonly used today are spectral-domain OCTA (SD-OCTA) and swept-source OCTA (SS-OCTA). Several studies have shown comparable results between the two types of devices in terms of FAZ area measurements (16) (17).…”

Section: Introductionmentioning

confidence: 80%

Automated measurement of the foveal avascular zone in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography

Gutierrez-Benitez

Palomino

Casas

2020

Preprint

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PURPOSE: To develop and evaluate an automated method to measure the foveal avascular zone (FAZ) area in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography (HS-OCTA). This method is referred to as the modified Kanno-Saitama macro (mKSM). METHODS: This cross-sectional study included 29 eyes of 25 healthy volunteers who underwent HS-OCTA at the macular area twice at the same time. Regardless of the quality of the images, all of them were included. Macular data on the superficial vascular plexus, intermediate capillary plexus and deep capillary plexus were processed by mKSM. The FAZ area was measured twice automatically using the mKSM and twice manually by two independent examiners. RESULTS: Intrascan intraclass coefficient ranged from 0,948 to 0,993 for manual measurements and was 1 for mKSM method. Interscan intraclass coefficients ranged from 0,925 to 0,973 for manual measurements and from 0,770 to 0,902 for mKSM method. Despite that the difference between human examiners is smaller than between human examiners and mKSM according to Bland-Altman plots, the scatterplots show a strong correlation between human and automatic measurements. The best results are obtained in intermediate capillary plexus. CONCLUSIONS: Automated determination of the FAZ area in HS-OCTA is feasible and less human-dependent by mKSM even if the image is not perfectly centred or has artefacts. The mKSM processing could contribute to our understanding of the three vascular plexuses.

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Quantitative Comparison of Retinal Vascular Features in Optical Coherence Tomography Angiography Images From Three Different Devices

Abstract: Vessel density showed good repeatability among the three devices, although there were differences in vessel parameters between the devices. Also, vessel parameters changed significantly after Frangi filtering. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:488-496.].

Cited by 24 publications

References 26 publications

Comparison of foveal avascular zone and retinal vascular density in healthy Chinese and Caucasian adults

Comparison of foveal avascular zone and retinal vascular density in healthy Chinese and Caucasian adults

Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

Automated measurement of the foveal avascular zone in healthy eyes on Heidelberg Spectralis Optical Coherence Tomography Angiography

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