Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device

The first virtual patient-specific thrombectomy procedure

“…In particular, the correct stent positioning appears to be an important procedural aspect to be taken into account. The complete stent expansion and clot compression in the second attempt, when compared to the first attempt, revealed the importance of the clot entrapment of the clot within the stent struts as a marker of potential success (Chueh et al, 2021;Kühn et al, 2020;Ospel et al, 2019;Tsumoto et al, 2017). Features like these can be clearly detected and foreseen by a computational simulation, which can help interventionists to optimize their treatment techniques, for example by modeling a different stent retriever.…”

“…Procedural success, defined as removal of the clot and revascularization of the brain, is dependent on the chance to remove the clot in toto with one or more passes. Many investigators have attempted to improve the interaction between thrombectomy devices and thrombus to increase successful revascularization rates (Chueh et al, 2021;Kühn et al, 2020;Ospel et al, 2019).…”

Multimodal Thrombectomy Device for Treatment of Acute Deep Venous Thrombosis

“…The adjustable double-balloon design of the MMSTC was effective at sequestering the thrombus and decreasing distal embolization in an ex vivo flow model. Previous studies have used similar thrombosis circuits to evaluate embolus volume, size, and particle counts [10][11][12][13][14] . One study identified that particle counts resulting from distal thrombus emboli can vary in size depending on the type of thrombolyic used 13 .…”

In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

“…The same group also evaluated the recanalization success of four different thrombectomy procedures: stent-retrieval only, stent-retrieval combined with a balloon-guided catheter, stent-retrieval combined with aspiration, and aspiration only (M. . (Chueh et al, 2020b) evaluated the performance of a new thrombectomy device that combines stent-retrieval and aspiration. (Johnson et al, 2020b(Johnson et al, , 2020a) compared the recanalization rates of stent-retriever-only and aspiration-only procedures specifically for calcified clots and platelet-contracted clots.…”

“…Other articles extend the models to include the A1 segment (Wenger et al, 2013), M1 and M2 divisions (Sanchez et al, 2020), M1-4 segments, anterior and posterior communicating arteries (Fennell et al, 2018), and the ophthalmic arteries (Girdhar et al, 2020). Others describe full Circle of Willis models (Chueh et al, 2020b;Maxim Mokin et al, 2015;Van Der Marel et al, 2016) or use a commercial model of the cerebrovasculature (Johnson et al, 2020a(Johnson et al, , 2020bMadjidyar et al, 2020Madjidyar et al, , 2015Tennuci et al, 2011). The majority of vascular models are tubular in design, apart from two studies where a hollowed-chamber was utilized (Good et al, 2020;Machi et al, 2017).…”